Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

Saxena, Anil Kumar; Phyu, Hnin P.; Al-Ani, Imad Matloub Dally; Oothuman, P

doi:10.15761/jts.1000150

Cited by 11 publications

(3 citation statements)

References 25 publications

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“…TH has also been shown to have beneficial effect at a dose of 1.0 g/kg body weight in diabetic [14] and ovariectomized [15] rats. Studies have demonstrated that TH could improve spatial learning and memory performance during chronic cerebral hypoperfusion-induced neurodegeneration [16] and induce protective effect against chronic cerebral hypoperfusion-induced neurodegeneration [17]. In addition, studies have reported that TH consumption could deter hippocampal morphological impairment in adult male rats [18] and improve hippocampal morphological impairment in ovariectomized rats [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats

Sairazi

Sirajudeen

Asari

et al. 2017

BMC Complement Altern Med

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BackgroundAdministration of KA on rodents has resulted in seizures, behavioral changes, oxidative stress, and neuronal degeneration on selective population of neurons in the brain. The present study was undertaken to investigate the extent of neuroprotective effect conferred by Malaysian Tualang Honey (TH), an antioxidant agent, in the cerebral cortex of rats against KA-induced oxidative stress and neurodegeneration in an animal model of KA-induced excitotoxicity.MethodsMale Sprague–Dawley rats were randomly divided into five groups: Control, KA-treated group, TH + KA-treated group, aspirin (ASP; anti-inflammatory agent) + KA-treated group and topiramate (TPM; antiepileptic agent) + KA-treated group. The animals were pretreated orally with drinking water, TH (1.0g/kg BW), ASP (7.5mg/kg BW) or TPM (40mg/kg BW), respectively, five times at 12 h intervals. KA (15mg/kg BW) was injected subcutaneously 30 min after last treatment to all groups except the control group (normal saline). Behavioral change was observed using an open field test (OFT) to assess the locomotor activity of the animals. Animals were sacrificed after 2 h, 24 h and 48 h of KA administration.ResultsKA significantly inflicted more neuronal degeneration in the piriform cortex and heightened the predilection to seizures as compared with the control animals. Pretreatment with TH reduced the KA-induced neuronal degeneration in the piriform cortex but failed to prevent the occurrence of KA-induced seizures. In the OFT, KA-induced animals showed an increased in locomotor activity and hyperactivity and these were attenuated by TH pretreatment. Furthermore, TH pretreatment significantly attenuated an increase of thiobarbituric acid reactive substances level and a decrease of total antioxidant status level enhanced by KA in the cerebral cortex.ConclusionThese results suggest that pretreatment with TH has a therapeutic potential against KA-induced oxidative stress and neurodegeneration through its antioxidant effect.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1534-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats

Sairazi

Sirajudeen

Asari

et al. 2017

BMC Complement Altern Med

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“…Furthermore, honey has been shown to reduce brain OS and enhance morphological hippocampus dysfunction in stressed rats, attenuating the cognitive impairment. It is also shown to ameliorate neurodegeneration and OS caused by chronic cerebral hypoperfusion in the midbrain of rat against frequent paraquat exposure [ 127 , 128 , 129 ]. In a Parkinson’s animal model, a study showed that pretreatment with Withania somnifera (ethanolic crude) declined the OS in 6-OHDA-induced rats.…”

Section: Nutraceuticals In Nds: Multi-targeted Avenuementioning

confidence: 99%

“…Moreover, Withania somnifera extract also decreased the increased activity of acetylcholinesterase and restored the activities of mitochondrial ETC complex. In the cortex and striatum of 3-nitropropionic acid-induced rats, attenuated mitochondrial enzyme complex activities and ATP synthesis have been shown to occur by treatment with Withania somnifera extract [ 129 ].…”

Section: Nutraceuticals In Nds: Multi-targeted Avenuementioning

confidence: 99%

Elucidating the Multi-Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases

Behl

Kaur

Sehgal

et al. 2021

IJMS

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The mechanisms underlying multifactorial diseases are always complex and challenging. Neurodegenerative disorders (NDs) are common around the globe, posing a critical healthcare issue and financial burden to the country. However, integrative evidence implies some common shared mechanisms and pathways in NDs, which include mitochondrial dysfunction, neuroinflammation, oxidative stress, intracellular calcium overload, protein aggregates, oxidative stress (OS), and neuronal destruction in specific regions of the brain, owing to multifaceted pathologies. The co-existence of these multiple pathways often limits the advantages of available therapies. The nutraceutical-based approach has opened the doors to target these common multifaceted pathways in a slow and more physiological manner to starve the NDs. Peer-reviewed articles were searched via MEDLINE and PubMed published to date for in-depth research and database collection. Considered to be complementary therapy with current clinical management and common drug therapy, the intake of nutraceuticals is considered safe to target multiple mechanisms of action in NDs. The current review summarizes the popular nutraceuticals showing different effects (anti-inflammatory, antioxidant, neuro-protectant, mitochondrial homeostasis, neurogenesis promotion, and autophagy regulation) on vital molecular mechanisms involved in NDs, which can be considered as complementary therapy to first-line treatment. Moreover, owing to its natural source, lower toxicity, therapeutic interventions, biocompatibility, potential nutritional effects, and presence of various anti-oxidative and neuroprotective constituents, the nutraceuticals serve as an attractive option to tackle NDs.

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Neuroprotective Effects of Honey: A Mechanistic View

Dar

2020

Therapeutic Applications of Honey and Its Phytochemicals

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Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

Cited by 11 publications

References 25 publications

Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats

Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats

Elucidating the Multi-Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases

Neuroprotective Effects of Honey: A Mechanistic View

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