Effect of therapeutic doses of radiotherapy on the organic and inorganic contents of the deciduous enamel: an in vitro study

Ferreira, Elza Maria de Sá; Soares, Luís Eduardo Silva; Antunes, Héliton Spíndola; Uemura, Sofia Takeda; Barbosa, Patricia da Silva; Salmon, Hélio Augusto; Sant'Anna, Giselle Rodrigues de

doi:10.1007/s00784-015-1686-y

Cited by 16 publications

(24 citation statements)

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“…In this regard, a previous follow-up study demonstrated that radiotherapy changed salivary properties and reduced the salivary flow and buffering capacity of individuals with Hodgkin's disease [Marangoni-Lopes et al, 2016]. Although the present study does not represent a real clinical condition of postradiation in the oral environment, we used a representative sample size and were able to demonstrate changes occurring in primary enamel and dentin, even at doses lower than those used previously [de Siqueira Mellara et al, 2014;de Sá Ferreira et al, 2016].…”

Section: Discussionmentioning

confidence: 69%

“…When one considers that the lower the microhardness, the lower the mineral content, another important aspect to be investigated is the mineral composition of irradiated enamel and dentin. In this regard, an early study [de Sá Ferreira et al, 2016] evaluated the effects of radiotherapy on the composition of primary enamel and concluded that radiotherapy reduced the organic content of the primary enamel. However, in this study, the authors evaluated only the changes occurring in enamel after the final dose of 5,400 cGy.…”

Section: Introductionmentioning

confidence: 99%

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Radiotherapy Reduces Microhardness and Mineral and Organic Composition, and Changes the Morphology of Primary Teeth: An in vitro Study

et al. 2018

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Objective: We aimed to evaluate whether radiotherapy causes changes in the mineral composition, hardness, and morphology of enamel and dentin of primary teeth. Materials and Methods: Thirty specimens of primary teeth were subjected to radiotherapy. At baseline and after 1,080, 2,160, and 3,060 cGy, the specimens were subjected to microhardness, FT-Raman spectroscopy, and scanning electron microscopy (SEM) analysis. The pH of artificial saliva was determined, as were the calcium and phosphate concentrations. The data were subjected to the Shapiro-Wilk normality test, showed a nonnormal distribution, and were compared by the Kruskal-Wallis test. Results: The results showed that the microhardness of the enamel surface decreased after 2,160 cGy (281.5 ± 58 kgf/mm²) when compared to baseline (323.6 ± 59.5 kgf/mm²) (p = 0.045). For dentin, the surface hardness decreased after 1,080 cGy (34.9 ± 11.4 kgf/mm²) and 2,160 cGy (26 ± 3.5 kgf/mm²) when compared to baseline (56.5 ± 7.7 kgf/mm²) (p < 0.0001). The mineral and organic contents of phosphate (p < 0.0001), carbonate (p < 0.0001), amide (p = 0.0002), and hydrocarbons (p = 0.0031) of enamel decreased after 3,060 cGy (5,178 ± 1,082, 3,868 ± 524, 999 ± 180, and 959 ± 168 kgf/mm², respectively). For dentin, we noticed a growing increase in phosphate v2, amide, and hydrocarbon content after 1,080 cGy (8,210 ± 2,599, 5,730 ± 1,818, and 6,118 ± 1,807 kgf/mm², respectively) and 2,160 cGy (1,0071 ± 2,547, 7,746 ± 1,916, and 8,280 ± 2,079 kgf/mm², respectively) and a reduction after 3,060 cGy (6,782 ± 2,175, 3,558 ± 1,884, and 3,565 ± 1,867 kgf/mm², respectively) (p < 0.0001). SEM images showed cracks on enamel and degradation of peritubular dentin. Conclusion: We concluded that radiotherapy caused a reduction in surface hardness, changed mineral and organic composition, and promoted morphological changes on the enamel and dentin of primary teeth.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Radiotherapy Reduces Microhardness and Mineral and Organic Composition, and Changes the Morphology of Primary Teeth: An in vitro Study

et al. 2018

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“…), or even chemical changes such as reduction of calcium, phosphorus, carbonate and phosphate, and dentine crystallinity (De Sá Ferreira et al . ).…”

Section: Discussionmentioning

confidence: 97%

“…In spite of its adhesion and polymerization mechanism, RelyX U200 resin cement had lower values of bond strength after radiotherapy, probably due to the reduction of calcium, phosphorus and carbon in the root dentine (De Sá Ferreira et al . ), which may generate fewer chemical bonds between cement and root dentine. In addition, the self‐adhesive materials require means of ionization for the chemical reaction, which altered by irradiation may reinforce this hypothesis (Mushashe et al .…”

Section: Discussionmentioning

confidence: 99%

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Longevity of bond strength of resin cements to root dentine after radiation therapy

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Effect of radiotherapy on the chemical composition of root dentin

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Background: The radiotherapy can directly affect the bond strength of the adhesive materials, interfering in the prognosis of restorative treatments, which may be caused by chemical changes in dentin structure. Methods: Twenty inferior homologues premolars were distributed in 2 groups (in vitro study) (n = 10): nonirradiated and irradiated. The specimens were submitted to the analysis of phosphate (ν 1 PO 4

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Effect of therapeutic doses of radiotherapy on the organic and inorganic contents of the deciduous enamel: an in vitro study

Abstract: Preventive measures should be included in the patient treatment protocol because of RT-induced chemical changes to the deciduous enamel.

Cited by 16 publications

References 51 publications

Radiotherapy Reduces Microhardness and Mineral and Organic Composition, and Changes the Morphology of Primary Teeth: An in vitro Study

Radiotherapy Reduces Microhardness and Mineral and Organic Composition, and Changes the Morphology of Primary Teeth: An in vitro Study

Longevity of bond strength of resin cements to root dentine after radiation therapy

Effect of radiotherapy on the chemical composition of root dentin

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