Effect of the cumin cyminum L. Intake on Weight Loss, Metabolic Profiles and Biomarkers of Oxidative Stress in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Abstract

Background: The current study was performed to determine the effects of cumin cyminum L. intake on weight loss and metabolic profiles among overweight subjects. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 78 overweight subjects (male, n = 18; female, n = 60) aged 18-60 years old. Participants were randomly assigned into three groups to receive: (1) cumin cyminum L. capsule (n = 26); (2) orlistat120 capsule (n = 26) and (3) placebo (n = 26) three times a day for 8 weeks. Anthropometric measures and fasting blood samples were taken at baseline and after 8 weeks of intervention. Results: Consumption of the Cuminum cyminum L. and orlistat120 resulted in a similar significant decrease in weight (-1.1 ± 1.2 and -0.9 ± 1.5 vs. 0.2 ± 1.5 kg, respectively, p = 0.002) and BMI (-0.4 ± 0.5 and -0.4 ± 0.6 vs. 0.1 ± 0.6 kg/m², respectively, p = 0.003) compared with placebo. In addition, taking Cuminum cyminum L., compared with orlistat and placebo, led to a significant reduction in serum insulin levels (-1.4 ± 4.5 vs. 1.3 ± 3.3 and 0.3 ± 2.2 µIU/ml, respectively, p = 0.02), HOMA-B (-5.4 ± 18.9 vs. 5.8 ± 13.3 and 1.0 ± 11.0, respectively, p = 0.02) and a significant rise in QUICKI (0.01 ± 0.01 vs. -0.005 ± 0.01 and -0.004 ± 0.01, respectively, p = 0.02). Conclusion: Taking cumin cyminum L. for eight weeks among overweight subjects had the same effects of orlistat120 on weight and BMI and beneficial effects on insulin metabolism compared with orlistat120 and placebo.

Evaluation the effect of 50 and 100 mg doses of Cuminum cyminum essential oil on glycemic indices, insulin resistance and serum inflammatory factors on patients with diabetes type II: A double-blind randomized placebo-controlled clinical trial

“…The result of this study indicated that green cumin has positive and significantly meaningful effect on glucose of serum and lipid profile. But in another study performed on overweight subjects, no meaningful effect of C. cyminum on plasma glucose in a fasting state and lipid profile was detected 24 . As most studies have been performed on laboratory animals,16, 25, 26, 27, 28, 29, 30 and due to lack of comparison on the rate of effectiveness of the different doses of this plant on patients with diabetes type II as well as controversial outcomes of the studies, it is essential to compare the effectiveness of the different doses of green cumin extract.…”

The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

“…Dietary supplements and placebo (paraffin) capsules were produced by the department of the formulation of Barij Medicinal Plants Research Center (Barij Essence Pharmaceutical, Kashan, Iran) [12]. To produce dietary supplement hard capsules, at first green tea, capsaicin and ginger essential oil was dissolved in poly ethylene glycol 4,000 in 25°C; then it was en-coated into a capsule [12]. Analysis of green tea, capsaicin and ginger capsules was done in the laboratory of Barij Essence, Kashan, Iran by the high-performance liquid chromatography method [12].…”

“…To produce dietary supplement hard capsules, at first green tea, capsaicin and ginger essential oil was dissolved in poly ethylene glycol 4,000 in 25°C; then it was en-coated into a capsule [12]. Analysis of green tea, capsaicin and ginger capsules was done in the laboratory of Barij Essence, Kashan, Iran by the high-performance liquid chromatography method [12]. Following analysis of green tea, it was detected that the major components were polyphenols including EGCG, epicatechin gallate, epicatechins, flavanols and caffeine.…”

“…Furthermore, the major compound of ginger included gingerols, zingerone and shogaols. The appearance of the placebo capsules, such as color, shape, size and packaging, was identical to that of green tea, capsaicin and ginger [12]. …”

Medicinal plants with cardiovascular effects (part 2): plant based review

“…Consumption of the Cuminum cyminum and orlistat120 resulted in a similar significant decrease in weight (-1.1 ± 1.2 and -0.9 ± 1.5 compared with placebo 0.2 ± 1.5 kg, respectively, p = 0.002) and BMI (-0.4 ± 0.5 and -0.4 ± 0.6 compared with placebo 0.1 ± 0.6 kg/m(2), respectively, p = 0.003). In addition, Cuminum cyminum L., compared with orlistat and placebo, led to a significant reduction in serum insulin levels (-1.4 ± 4.5 vs. 1.3 ± 3.3 and 0.3 ± 2.2 µIU/ml, respectively, p = 0.02), HOMA-B (-5.4 ± 18.9 vs. 5.8 ± 13.3 and 1.0 ± 11.0, respectively, p = 0.02) and a significant rise in QUICKI (0.01 ± 0.01 vs. -0.005 ± 0.01 and -0.004 ± 0.01, respectively, p = 0.02) [139].…”