The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Abstract

Background: This study was conducted to determine the effects of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles among overweight women. Methods: This randomized double-blind placebo-controlled clinical trial was implemented among 50 overweight women. Participants were randomly divided into 2 groups. Group A received dietary supplements containing 125 mg green tea, 25 mg capsaicin and 50 mg ginger extracts (n = 25) group B received placebos (n = 25) twice with lunch and twice with dinner daily for 8 weeks. Results: Compared with placebo, taking dietary supplements containing green tea, capsaicin and ginger resulted in a significant decrease in weight (-1.8 ± 1.5 vs. +0.4 ± 1.2 kg, respectively, p < 0.001) and body mass index (BMI; -0.7 ± 0.5 vs. +0.1 ± 0.5 kg/m², respectively, p < 0.001). In addition, subjects who received green tea, capsaicin and ginger co-supplements had significantly decreased serum insulin concentrations (-2.6 ± 3.9 vs. -0.6 ± 2.0 µIU/mL, p = 0.02), homeostatic model of assessment for insulin resistance (-0.5 ± 0.8 vs. -0.05 ± 0.6, p = 0.01), and increased quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. +0.001 ± 0.01, p = 0.008) and plasma glutathione (GSH) levels (+73.8 ± 120.6 vs. -28.3 ± 193.4 µmol/L, p = 0.03) compared with the placebo. Conclusions: Our study indicated that taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma GSH levels.

The Effect of Aerobic Trainings and Green Tea Supplementation on Cardio Metabolic Risk Factors in Overweight and Obese Females: A Randomized Trial

“…However, no significant changes occurred in FBS, HDL, TC, and WHR (P > 0.05). These findings are consistent with that of Cardoso et al ( 8 ), Contro et al ( 21 ), Lee et al ( 22 ), Taghizadeh et al ( 23 ), and Martin et al ( 24 ), and inconsistent with Zhou et al ( 14 ) and Narayani et al ( 2 ).…”

“…Another study on a four-week intake of GT diet supplemented with resistance training reported that GT consumption with resistance training reduced triglyceride reserves ( 8 ). In contrast, a study on the effect of GT on overweight females showed no significant differences in LDL and HDL ( 23 ).…”

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

“…Camellia sinensis or green tea was investigated in 12 studies (n = 1179), seven as single‐herb products, four as combination preparations and one as part of a traditional Chinese medicine . Dosages of C. sinensis were reported in six studies, ranging from 200 mg to 2400 mg daily.…”

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

“…The mechanism might partially be due to inhibition of the secretion of ghrelin and raising the level of adiponectin. Taghizadeh et al demonstrated that daily consumption of a mixture containing 125 mg green tea, 25 mg capsaicin, and 50 mg ginger extracts for eight weeks significantly reduced the weight, body mass index (BMI), plasma GSH level, and insulin metabolism markers in overweight women [162]. However, a 4-week decaffeinated green tea extract (571 mg/d) intervention did not alter total fatty acid concentrations in recreationally active males, although it enhanced substrate utilization and subsequent performance indices [163].…”