Medicinal plants with cardiovascular effects (part 2): plant based review

Al-Snafi, Prof Dr Ali Esmail

doi:10.9790/3013-067034362

Cited by 10 publications

(11 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Garlic also inhibits metastasis by preventing the binding of circulating cancer cells to the blood vessel walls (Wei et al, ). It was observed that the garlic extract restricted the growth of many cancers including breast, bladder, skin, colon, esophagus, stomach, and lung cancers (Al‐Snafi, ; H. A. R. Suleria, Butt, Khalid, et al, ). The results of these studies showed that the beneficial and anticancer effects of garlic had a direct relationship with the release of OSCs and allicin (C 6 H 10 S 2 O), as well as the DADS (C 6 H 10 S 2 ) production capacity (Mathan, Singh, & Singh, ).…”

Section: A Sativummentioning

confidence: 99%

Allium vegetables for possible future of cancer treatment

Asemani

Zamani

Bayat

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerous diseases. The phytochemical analysis of various Allium genus members showed that, to date, 16 species have proved potential anticancer properties due to the accumulation of various sulfur and organic compounds like S‐allyl mercaptocysteine, quercetin, flavonoids, and ajoene. These compounds with various mechanisms such as hindering cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells. Similar to garlic and onion, other species have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents. Therefore, evaluating the main ingredients and studying their anticancer mechanisms are of great importance. In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further researches on the treatment and prevention of cancers.

show abstract

Section: A Sativummentioning

confidence: 99%

Allium vegetables for possible future of cancer treatment

Asemani

Zamani

Bayat

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The vasorelaxant activity of echinacoside, a phenylethanoid glycoside isolated from Cistanche tubulosa, and its possible underlying mechanism on isolated rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 microM) and KCl (60 mM) was investigated. Echinacoside (30-300 microM) exhibited an acute relaxation in endothelium-intact rings in a concentration-dependent manner, while this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of the endothelial nitric oxide synthase (eNOS) inhibitor, N (W)-nitro-L-arginine methyl ester (L-NNA, 100 microM), an unselective soluble guanylate cyclase blocker, methylene blue (10 microM) and the selective sGC inhibitor 1 H- [1,2,4] oxadiazolo [4,3-A]quinoxalin-1-one (ODQ, 1 microM); in addition, atropine (1 microM), a selective muscarinic receptor antagonist, partially affected the relaxation. However, the cyclooxygenase inhibitor indomethacin (5 microM) had no influence on the relaxant action.…”

Section: Cistanche Tubulosamentioning

confidence: 99%

“…Vascular endothelium releases many vasoactive substances, which regulated and maintained the overall cardiovascular homeostasis. The previous studied showed that many medicinal plants possessed hypotensive effects and affected vascular activity either by direct effect on vascular smooth muscles or indirectly by affecting endothelium vasoactive substances (1)(2)(3) . The current review highlighted the medicinal plants with hypotensive and vascular effects as promising future therapies because of efficacy and safety.…”

Section: Introductionmentioning

confidence: 99%

Hypotensive and vascular activities of medicinal plants

Al-Snafi¹

2022

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

Plants are a valuable source of a wide range of secondary metabolites, which are used as pharmaceuticals preparations. The previous studied showed that many medicinal plants possessed hypotensive effects and affected vascular activity either by direct effect on vascular smooth muscles or indirectly by affecting endothelium vasoactive substances. The current review was designed to highlight the medicinal plants with hypotensive and vascular effects as promising future therapies because of efficacy and safety.

show abstract

“…The center of origin of saffron crop is not clear, as earlier Middle East (Asia Mi Turkestan and Iran) was considered as its center of origin [39], whereas, later on, C Treatment with ethanolic extract of saffron, was seen to have antiproliferative effect by significantly reducing the longevity of malignant carcinomic human alveolar basal epithelial cells [23]. Saffron derivatives having higher anti-carcinogenic potential has attributes of increased apoptosis, reduction in blood vessels [24], inhibiting RNA and DNA synthesis [25] and regulating lipid peroxidation and antioxidant activity [26].…”

Section: Center Of Origin and Geographical Distribution Of Saffron Cropmentioning

confidence: 99%

Corm Rot of Saffron: Epidemiology and Management

et al. 2021

View full text Add to dashboard Cite

Saffron, comprising of dried stigmas of the plant known as Crocus sativus, is one of the most important and scantly cultivated agricultural products. It has been used as a precious spice for the last at least 3500 years. Due to its numerous medicinal qualities and pharmacological applications, it is considered as a “golden condiment”, and its demand and consumptions has risen over a period of time. Although efforts are continuously being made to enhance the productivity in the traditional areas and promote the cultivation of saffron in the newer areas, there are several constraints hindering these efforts. Prevalence of corm rot is one such limiting factor which results in the reduction in saffron production and decline in the area under its cultivation. The disease not only reduces the yield substantially, but also adversely affects the production of daughter corms. Complete understanding and knowledge about the disease is still lacking due to the inadequate information about its etiology and epidemiology. Moreover, due to the non-availability of resistant genotypes and lack of improved cultural practices, presently no effective and sustainable management strategies are available. This review article gives an overall account of the history and impact of saffron corm rot, its present status, yield losses caused by it, dynamics of the pathogens associated with the disease, their survival and dispersal, factors influencing disease intensity, epidemiology and sustainable management strategies. As comprehensive information on the disease is presently not available, an attempt has been made to review the current knowledge regarding corm rot of saffron. The information about the disease discussed here can eventually be beneficial for the growers, students, researchers, plant protection organizations, development departments, extension workers, policy makers, government agencies and public organizations.

show abstract

Medicinal plants with cardiovascular effects (part 2): plant based review

Cited by 10 publications

References 51 publications

Allium vegetables for possible future of cancer treatment

Allium vegetables for possible future of cancer treatment

Hypotensive and vascular activities of medicinal plants

Corm Rot of Saffron: Epidemiology and Management

Contact Info

Product

Resources

About