Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerous diseases. The phytochemical analysis of various Allium genus members showed that, to date, 16 species have proved potential anticancer properties due to the accumulation of various sulfur and organic compounds like S‐allyl mercaptocysteine, quercetin, flavonoids, and ajoene. These compounds with various mechanisms such as hindering cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells. Similar to garlic and onion, other species have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents. Therefore, evaluating the main ingredients and studying their anticancer mechanisms are of great importance. In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further researches on the treatment and prevention of cancers.

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Canada thistle (Cirsium arvense L.) growing in spring wheat (Triticum aestivum) is difficult to control for several reasons. First, it is a perennial weed that has an extensive root system. Second, the cash‐crop wheat prevents the use of many chemicals, and third, Canada thistle is becoming resistant to many single action herbicides. The objective of this study was to evaluate the effect of postemergence herbicide applications on Canada thistle control growing in a spring wheat field. Replicated studies conducted in Russia between 2015 and 2017 evaluated the impact of different herbicide mixtures on Canada thistle control. The formulated mixtures of (iodosulfuron/mesosulfuron/antidote mefenpyr‐diethyl) mixed with triasulfuron and metsulfuron and triasulfuron + metsulfuron increased wheat yields 48 to 60% and provided the greatest (>85%) Canada thistle suppression in all experiments. Generally, (aminopyralid/florasulam), triasulfuron and (2,4‐D/florasulam) provided little control. It can be concluded that in all treatments, the herbicide mixtures did not provide 100% control, and therefore care must be used to prevent the creation of herbicide resistant Canada thistle. Core Ideas Formulated mixtures of herbicides containing (iodosulfuron/mesosulfuron/antidote mefenpyr‐diethyl) and triasulfuron plus metsulfuron provided the most effective Canada thistle suppression. Canada thistle was better controlled at the early stage of spring wheat. Herbicide mixtures containing multiple modes of action was more effective than a single mode of action herbicide in the control of Canada thistle in wheat.

The calamity of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), COVID-19, is still a global human tragedy. To date, no specific antiviral drug or therapy has been able to break the widespread of SARS-CoV2. It has been generally believed that stimulating protective immunity via universal vaccination is the individual strategy to manage this pandemic. Achieving an effective COVID-19 vaccine requires attention to the immunological and non-immunological standpoints mentioned in this article. Here, we try to introduce the considerable immunological aspects, potential antigen targets, appropriate adjuvants as well as key points in the various stages of COVID-19 vaccine development. Also, the principal features of the preclinical and clinical studies of pioneering COVID-19 vaccine candidates were pointed out by reviewing the available information. Finally, we discuss the key challenges in the successful design of the COVID-19 vaccine and address the most fundamental strengths and weaknesses of common vaccine platforms.

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