Effect of punicic acid naturally occurring in food on lipid peroxidation in healthy young humans

Gao, Yuan; Wahlqvist, Mark L.; Yuan, Jingqun; Wang, Qiaomei; Li, Duo

doi:10.1002/jsfa.3729

Cited by 22 publications

(22 citation statements)

References 31 publications

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“…High cholesterol:HDL-C ratios ($ 4) are also associated with coronary artery disease (15) , and we have found a significant difference in cholesterol:HDL-C ratio after adjusting for baseline values, in PSO group v. placebo group. A recent study in healthy human subjects reported Trichosanthes kirilowii seeds, naturally occurring sources of PA, had no significant effect on serum lipids (16) contrary to our finding which may be attributable to the pre-existence of hyperlipidaemia in the present study. Current data on the effect of PSO on lipid concentration and metabolism are controversial (8,9,17) .…”

Section: Discussioncontrasting

confidence: 99%

Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial

et al. 2010

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In vitro and in vivo studies have shown that punicic acid, a type of conjugated fatty acid and the main constituent of pomegranate seed oil (PSO), has anti-atherogenic effects. The present study aimed at determining the effect of PSO treatment on serum lipid profiles. This double-blind placebo-controlled randomised clinical trial included fifty-one hyperlipidaemic subjects, diagnosed according to National Cholesterol Education Program definition, and randomly assigned to the PSO and the control groups. The PSO and placebo groups received 400 mg PSO and placebo twice daily, respectively and were followed up for 4 weeks. Serum concentrations of lipids and lipoproteins were measured before and 4 weeks after intervention. Mean concentration of TAG and the TAG:HDL cholesterol (HDL-C) ratio were significantly decreased after 4 weeks in the PSO group as compared with baseline values (2·75 (SD 1·40) v. 3·45 (SD 1·56) mmol/l, P¼ 0·009 and 5·7 (SD 4·6) v. 7·5 (SD 5·0), P¼ 0·031, respectively). The treatment effect was statistically significant in the PSO group as compared with controls in diminution of cholesterol:HDL-C ratio (5·4 (SD 1·5) v. 5·9 (SD 1·4), P, 0·05) adjusted for baseline values. We found a mean difference for PSO v. placebo in HDL-C concentration (0·13 v. 20·02 mmol/l) and cholesterol:HDL-C ratio (20·42 v. 0·01, P,0·05). Serum cholesterol, LDL cholesterol and glucose concentrations and body composition variables remained unchanged. It is concluded that administration of PSO for 4 weeks in hyperlipidaemic subjects had favourable effects on lipid profiles including TAG and TAG:HDL-C ratio. Pomegranate seed oil: Hyperlipidaemia: Randomised clinical trialsNormalisation of dyslipidaemia, a modifiable risk factor, can prevent or reduce the risk of CVD, which is a leading cause of death worldwide (1,2) .In order to treat dyslipidaemia, different pharmacologic and non-pharmacologic approaches have been used. Statins are the first-line therapy for management of increased LDL cholesterol (LDL-C), despite adverse effects such as gastrointestinal symptoms and muscle aches (3) . Although fibrates may decrease serum TAG and increase serum HDL cholesterol (HDL-C), more powerful drugs for normalisation of these lipids need to be investigated.Conjugated fatty acids are well-known hypolipidaemic agents (4,5) documented for their effect on lipid metabolism (6) . PSO (Punica granatum) consists of about 80 % conjugated octadecatrienoic fatty acids, with a high content of 9-cis, 11-trans, 13-cis acid or punicic acid (PA), one of the isomers of conjugated linolenic acid (CLN) (7) ; animal studies report controversial results for the hypolipidaemic role of PSO (8,9) .Although Arao et al. (8) showed that PSO supplementation in obese hyperlipidaemic Otsuka-Long-Evans-Tokushima fatty rats reduces TAG accumulation, Yang et al. (9) demonstrated that PSO does not alter serum cholesterol concentration.Considering the lack of data on the effect of PSO on lipid profiles in human subjects, the present study investigated the effect of PSO ...

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Section: Discussioncontrasting

confidence: 99%

Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial

et al. 2010

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“…Interventional studies with 3 g of PA fed to healthy young human subjects for 28 d did not result in any effect on weight reduction or serum lipid profile. The urinary 8‐iso‐prostaglandin F2α level increased significantly, but there was no significant effect on cholesterol‐reactive proteins, insulin, glucose, and insulin resistance (Yuan and others ). However, in a double‐placebo clinical trial with 400 mg of PSO, given twice per day for 4 wk to hyperlipidemic subjects, it showed its anti‐atherogenic effect on lipid profiles including TAG and the TAG: HDL‐C ratio (Mirmiran and others ).…”

Section: Biological Propertiesmentioning

confidence: 99%

Health Benefits of Punicic Acid: A Review

Pamisetty

Venkataramanamma

Singh

et al. 2015

Comp Rev Food Sci Food Safe

121

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Punicic acid (PA) is a polyunsaturated fatty acid (18:3 n-5), which is classified as a conjugated linolenic acid. PA is also referred as a "super CLnA" whose effect is even more potent than that of an ordinary CLnA. It is found mainly in the seeds of pomegranate fruit (Punica granatum) and Trichoxanthes kirilowii and some other minor sources. It possesses a wide array of biological properties including antidiabetic, antiobesity, antiproliferative, and anticarcinogenic activity against various forms of cancer. In spite of this, PA has not been explored as a nutraceutical or as an ingredient of food products which can be aimed at specific consumer target groups. This review details the various health-beneficial properties of PA and explores the possibilities of its utilization as an active ingredient in various food products.

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“…Antioxidant and antiinflammatory activities are the main features of PSO which results from inhibition of lipid peroxidation and neutrophil-activation 37,39,51 . Effects of PSO on body weight and serum lipid profile are inconsistent and many studies confirmed weight reducing effects but the effects of PSO on reducing in serum triglyceride, phospholipid, cholesterol, and LDL-cholesterol levels are contradictory 40,52 . PSO reduces body weight, leptin and insulin levels, enhances glucose tolerance, improves peripheral insulin sensitivity, increases carbohydrate oxidative capacity, and inhibits the progression of type2 diabetes 31,53 .…”

Section: Pharmacological Actions Of Psomentioning

confidence: 99%

Untitled

2016

IJPSR

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Effect of punicic acid naturally occurring in food on lipid peroxidation in healthy young humans

Abstract: BACKGROUND: The aim of this study was to investigate the physiological roles of punicic acid (PA) naturally occurring in a Chinese snack food, Trichosanthes kirilowii (TK) seeds, in healthy young subjects.

Cited by 22 publications

References 31 publications

Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial

Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial

Health Benefits of Punicic Acid: A Review

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