Health Benefits of Punicic Acid: A Review

Background:Rapid increasing prevalence of diabetes mellitus is a serious health concern in the world. New data determined that the pathogenesis of diabetes mellitus is chronic low-grade inflammation, resulting insulin resistance. Pomegranate seed oil (PSO) has anti-inflammatory effects; though it may reduce insulin resistance and improve glycemia in diabetes mellitus. The present study has been designed to investigate the effects of PSO as a natural dietary component on metabolic state of patients with Type 2 diabetes mellitus.Methods:In a randomized double-blind clinical trial study, 80 patients (28 men) with Type 2 diabetes were randomly allocated to the intervention and control groups. The intervention group consumed PSO capsules, containing 1000 mg PSO twice daily (2000 mg PSO), whereas controls take placebo for 8 weeks. The participants followed their previous dietary patterns and medication use. Dietary factors and metabolic factors including lipid profile, fasting plasma sugar, and insulin and were assayed at the baseline and after 8 weeks.Results:Participants in two intervention and control group were similar regarding anthropometric and the dietary factors at baseline and after trial (P > 0.05). Mean level of total cholesterol, triglyceride, low-density lipoprotein-cholesterol, and high-density lipoprotein was not different significantly between groups after trial (P > 0.05). Consumption of PSO did not significantly affect the levels of parameters such as fasting blood sugar (FBS), insulin, HbA1c, alanine transferase, and homeostasis model assessment-insulin resistance.Conclusions:Consumption of 2000mg PSO per day for 8 weeks had no effect on FBS, insulin resistance and lipid profile in diabetic patients.

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“…PA may increases gene expression of PPARs and thus improves glucose homeostasis and inflammation-related insulin resistance. [24]…”

Section: Discussionmentioning

confidence: 99%

Effects of pomegranate seed oil on metabolic state of patients with Type 2 diabetes mellitus

et al. 2016

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“…It is possible that PuA is the most studied component because of its dominance in the oil . The biological properties of PSO have been well‐investigated and elucidated in several reviews . Additional health attributes have been reported to include anti‐osteoporosis, hepatoprotection, neuroprotection, promotion of peak bone mass and insulin resistance reduction .…”

Section: Biological Properties and Possible Mechanisms Of Psomentioning

confidence: 99%

Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health‐Promoting Properties

Adu‐Frimpong

Omari‐Siaw

Mukhtar

et al. 2018

Euro J Lipid Sci & Tech

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Emerging evidence has suggested that nutraceutical ingredients like pomegranate seed oil (PSO) possesses health‐promoting effects in cell and animal models. However, these health benefits (anticancer, antioxidant, anti‐inflammatory, anti‐diabetic, and so on) are limited by low physicochemical stability, slow intestinal absorption, and rapid metabolism of PSO. In order to overcome these drawbacks, some carriers viz., nanoemulsion, encapsulation, and nanoparticles are developed recently. This paper assesses the chemical compositions and physicochemical properties of PSO, as well as biological activities and possible mechanisms. It also discusses the formulation of PSO for improved stability and health‐promoting activities. Practical Applications: This review highlights the prospects of PSO formulation. The relevance of this study is that the stability and biological properties of PSO could be enhanced through nanocarriers. A formulated PSO has a potential use in nutraceutical, functional foods, pharmaceutical and cosmetic industries. PSO, a source of various nutrients and antioxidants with immense benefits to human health is incorporated into nanocarriers such as microencapsulation, nanoemulsion and nanoparticle. This improved the health‐promoting benefits of the oil.

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“…Hence, pomegranate seed powder (PSP) with high content of seed oil possessing PA, could be utilized for the development of food products, which could be consumed by precise consumers in particular and also by general consumers. PSP has not yet being exploited by food industries as a functional ingredient (Aruna, Venkataramanamma, Singh, & Singh, ). In this study an attempt has been made to utilize PSP as a functional ingredient and also to optimize the conditions for the preparation of cereal bar (ready to eat sweet product) using Central Composite Rotational Design (CCRD).…”

Section: Introductionmentioning

confidence: 99%

Development of ω‐5 and antioxidant enriched bar with pomegranate seed powder

Pamisetty

Juvvi

Chetana

et al. 2020

J Food Process Preserv

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Pomegranate seed oil (PSO) is a rich source of punicic acid (PA). The seeds were fractionated and 0.15mm fraction of pomegranate seed powder (PSP) was incorporated in bar type product (pomegrain bar). The present study was aimed to see the effects of critical variables, such as %PSP (4.5–75) and temperature (101–158°C) on response variables (PA recovery, total poly phenols, radical‐scavenging activity, hardness, color, and overall quality) of pomegrain bar. The experimental design was engendered for optimization of critical variables in response surface methodology. Results predicted that the optimum levels for critical variables are: PSP 55% and temperature 118°C which resulted in formulation of pomegrain bar having 84% of PA recovery and overall quality comparable with control. Practical applications Pomegranate seeds are virtually discarded from the industry. The seeds possess PSO which is a rich source of PA. PA possesses a wide array of beneficial biological activities including bone health maintenance, antioxidant, anticancer properties, etc. PA rich seed powder fraction was incorporated in the bar type product which could be used as a vehicle for the consumption of PA. The intent of the research is not only to create a vehicle for PA consumption but also to utilize the waste emanating from the industry.

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Health Benefits of Punicic Acid: A Review

Cited by 119 publications

References 91 publications

Effects of pomegranate seed oil on metabolic state of patients with Type 2 diabetes mellitus

Effects of pomegranate seed oil on metabolic state of patients with Type 2 diabetes mellitus

Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health‐Promoting Properties

Development of ω‐5 and antioxidant enriched bar with pomegranate seed powder

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