Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health‐Promoting Properties

Abstract

Emerging evidence has suggested that nutraceutical ingredients like pomegranate seed oil (PSO) possesses health‐promoting effects in cell and animal models. However, these health benefits (anticancer, antioxidant, anti‐inflammatory, anti‐diabetic, and so on) are limited by low physicochemical stability, slow intestinal absorption, and rapid metabolism of PSO. In order to overcome these drawbacks, some carriers viz., nanoemulsion, encapsulation, and nanoparticles are developed recently. This paper assesses the chemical compositions and physicochemical properties of PSO, as well as biological activities and possible mechanisms. It also discusses the formulation of PSO for improved stability and health‐promoting activities. Practical Applications: This review highlights the prospects of PSO formulation. The relevance of this study is that the stability and biological properties of PSO could be enhanced through nanocarriers. A formulated PSO has a potential use in nutraceutical, functional foods, pharmaceutical and cosmetic industries. PSO, a source of various nutrients and antioxidants with immense benefits to human health is incorporated into nanocarriers such as microencapsulation, nanoemulsion and nanoparticle. This improved the health‐promoting benefits of the oil.

Rare fatty acids and lipids in plant oilseeds: occurrence and bioactivity

“…Application of punicic acid in therapy however poses some questions: it is slowly absorbed and it is rapidly metabolized forming other conjugated isomeric linolenic fatty acids such as catalpic and αand β-eleostearic acids. Alternatively, the use of appropriate formulations of pomegranate seed oil such as encapsulation into lipid-based carrier systems, nanoemulsion delivery systems or nanodispersions is being considered to protect the active fatty acids from degradation (Adu-Frimpong et al 2018).…”

Superfruits in China: Bioactive phytochemicals and their potential health benefits – A Review

“…The fruit known as pomegranate ( Punica granatum ) originated from the Middle East, then extended to Mediterranean areas, as well as in countries such as Iran, India, China, Japan, and Russia. Pomegranate has been used as a traditional medicine in Asian cultures to treat different ailments (Adu‐frimpong et al., 2018 ). Many epidemiological studies of the potential effects of pomegranate on cancer prevention, such as lung cancer (Khan et al, 2007 ), skin cancer (Rout & Banerjee, 2007 ), prostate cancer (Malik et al., 2005 ), breast cancer (Toi et al, 2003), etc.…”

“…In addition, emerging evidence has suggested that nutraceutical ingredients like PSO possessed health‐promoting effects in cell and animal models. However, these health benefits (anticancer, antioxidant, anti‐inflammatory, anti‐diabetic, and so on) are limited by low physicochemical stability, slow intestinal absorption, and rapid metabolism of PSO (Adu‐frimpong et al., 2018 ).…”

Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice

“…Previous work suggested that cuminaldehyde could improve the activity of liver enzymes in vitro , but, its in‐vivo antihepatotoxicity has not been reported yet. Like other natural essential oils (EOs), the use of free cuminaldehyde usually leads to decreased bioactivity because of low bioavailability caused by volatilisation, hydrophobicity and rapid enzymatic metabolisation . Cuminaldehyde could therefore be formulated via appropriate novel techniques to enhance its oral bioavailability and therapeutic efficacy as other natural bioactive compounds .…”

“…Like other natural essential oils (EOs), the use of free cuminaldehyde usually leads to decreased bioactivity because of low bioavailability caused by volatilisation, hydrophobicity and rapid enzymatic metabolisation. [24,25] Cuminaldehyde could therefore be formulated via appropriate novel techniques to enhance its oral bioavailability and therapeutic efficacy as other natural bioactive compounds. [20,25,26] Several reports indicated that carriers such as liposomes, cyclodextrin inclusion complexes and drugin-cyclodextrin-in-liposome systems have been used to encapsulate various EOs and their components, viz.…”