Effect of probiotics on aspirin-induced gastric mucosal lesions

Senol, Altug; Işler, Mehmet; Karahan, Aynur Gül; Kılıç, Gülden Başyiğit; Kuleaşan, Hakan; Goren, Ibrahim; Sarıtaş, Ülkü; Kaya, Selçuk; Çiriş, Metin; Aktürk, Onur; Arıdoğan, Buket Cicioğlu; Demırın, Hilmi; Cakmakçi, Lütfü M

doi:10.4318/tjg.2011.0151

Cited by 20 publications

(21 citation statements)

References 50 publications

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“…Curiously, one study [28] demonstrated that bacterial colonization occurs rapidly after ulcer induction and in particular, colonization of certain bacteria including Lactobacillus could significantly improves gastric ulcer healing. Other studies have shown that probiotic bacteria Lactobacillus species, Saccharomyces boulardii , Escherichia coli strain Nissle 1917 are effective in preventing and treating acute gastric damage associated with acetic acid [12], stress [13], aspirin [29], ethanol [30], ibuprofen [31] and indomethacin [32] induced gastric ulcers. In humans, circumstantial evidence suggests that regular ingestion of a Lactobacillus -containing product protects the integrity of the gastric mucosal barrier against indomethacin [32], while others [15] have reported that the effect of using probiotic bacteria along with triple therapy is no better than using triple therapy alone for treatment of gastric ulcers.…”

Section: Discussionmentioning

confidence: 99%

The Probiotic Mixture VSL#3 Accelerates Gastric Ulcer Healing by Stimulating Vascular Endothelial Growth Factor

2013

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Studies assessing the effect and mechanism of probiotics on diseases of the upper gastrointestinal tract (GI) including gastric ulcers are limited despite extensive work and promising results of this therapeutic option for other GI diseases. In this study, we investigated the mechanisms by which the probiotic mixture VSL#3 (a mixture of eight probiotic bacteria including Lactobacilli, Bifidobacteria and Streptococcus species) heals acetic acid induced gastric ulcer in rats. VSL#3 was administered orally at low (6×109 bacteria) or high (1.2×1010 bacteria) dosages from day 3 after ulcer induction for 14 consecutive days. VSL#3 treatments significantly enhanced gastric ulcer healing in a dose-dependent manner. To assess the mechanism(s) whereby VSL#3 exerted its protective effects, we quantified the gene expression of several pro-inflammatory cytokines, protein and expression of stomach mucin-Muc5ac, regulatory cytokine-IL-10, COX-2 and various growth factors. Of all the components examined, only expression and protein production of VEGF was increased 332-fold on day 7 in the ulcerated tissues of animals treated with VSL#3. Predictably, animals treated with VEGF neutralizing antibody significantly delayed gastric ulcer healing in VSL#3 treated animals. This is the first report to demonstrate high efficacy of the probiotic mixture VSL#3 in enhancing gastric ulcer healing. Probiotic efficacy was effective at higher concentrations of VSL#3 by specifically increasing the expression and production of angiogenesis promoting growth factors, primarily VEGF.

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Section: Discussionmentioning

confidence: 99%

The Probiotic Mixture VSL#3 Accelerates Gastric Ulcer Healing by Stimulating Vascular Endothelial Growth Factor

2013

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“…In a recent study conducted by Senol and colleagues, a probiotic mixture including 13 strains of human origin was effective against aspirin-induced gastric mucosal damage in rats according to macroscopic examination with only ten rats in each treatment group, although the histological analysis showed no effect [20]. In addition to applying a different NSAID than in the present study, their study protocol included both a longer prophylactic probiotic supplementation (14 days) and fasting period prior to the challenge with aspirin (14 hours), while the animals were euthanized just 3 hours after the administration of aspirin.…”

Section: Discussionmentioning

confidence: 99%

“…In vitro studies with Lactobacillus casei DN-114 001 [18] and animal studies applying Lactobacillus casei strain Shirota [19] and a multistrain mixture of human origin [20] have yielded promising results. In clinical trials, Lactobacillus rhamnosus GG (LGG) has been shown to reduce indomethacin-induced gastric permeability [13] and the multistrain supplement VSL#3 has been shown to alleviate inflammation caused by indomethacin [14].…”

Section: Introductionmentioning

confidence: 99%

Bifidobacterium animalisssp.lactis420 Protects against Indomethacin-Induced Gastric Permeability in Rats

Lyra

Saarinen

Putaala

et al. 2012

Gastroenterology Research and Practice

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Gastrointestinal (GI) adverse effects such as erosion and increased permeability are common during the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Our objective was to assess whetherBifidobacterium animalisssp.lactis420 protects against NSAID-induced GI side effects in a rat model. A total of 120 male Wistar rats were allocated into groups designated as control, NSAID, and probiotic. The NSAID and probiotic groups were challenged with indomethacin (10 mg/kg−1; single dose). The probiotic group was also supplemented daily with 1010 CFU ofB. lactis420 for seven days prior to the indomethacin administration. The control group rats received no indomethacin or probiotic. The permeability of the rat intestine was analysed using carbohydrate probes and the visual damage of the rat stomach mucosa was graded according to severity.B. lactis420 significantly reduced the indomethacin-induced increase in stomach permeability. However, the protective effect on the visual mucosal damage was not significant. The incidence of severe NSAID-induced lesions was, nevertheless, reduced from 50% to 33% with the probiotic treatment. To conclude, theB. lactis420 supplementation protected the rats from an NSAID-induced increase in stomach permeability and may reduce the formation of more serious GI mucosal damage and/or enhance the recovery rate of the stomach mucosa.

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“…У праці Senol та співавт. [19], які вводили муль-тиштамний пробіотик (4 штами Lactobacillus fermentum, 3 штами Lactobacillus plantarum, 6 штамів Enterococcus faecium) впродовж 14 діб, був продемонстрований профілактичний ефект на ураження в шлунку щурів, викли-кані аспірином. Автори пояснили виявлений ефект зниженням ПОЛ, посиленням утво-рення секреторного імуноглобуліну А та зменшенням дегрануляції тучних клітин під впливом пробіотиків.…”

Section: результати та їх обговоренняunclassified

Еffects of Mono-, Poly- And Composite Probiotics on the Ulceration Caused by Restraint Stress

Virchenko¹,

Falalyeyeva²,

Tv³

et al. 2015

Fiziol Zh

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Effect of probiotics on aspirin-induced gastric mucosal lesions

Cited by 20 publications

References 50 publications

The Probiotic Mixture VSL#3 Accelerates Gastric Ulcer Healing by Stimulating Vascular Endothelial Growth Factor

The Probiotic Mixture VSL#3 Accelerates Gastric Ulcer Healing by Stimulating Vascular Endothelial Growth Factor

Bifidobacterium animalisssp.lactis420 Protects against Indomethacin-Induced Gastric Permeability in Rats

Еffects of Mono-, Poly- And Composite Probiotics on the Ulceration Caused by Restraint Stress

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