Еffects of Mono-, Poly- And Composite Probiotics on the Ulceration Caused by Restraint Stress

Virchenko, OV; Falalyeyeva, Tetyana; Tv, Beregova; My, Spivak; Lm, Lazarenko; Om, Demchenko

doi:10.15407/fz61.01.035

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…Recent studies on stress-induced gastric mucosal lesions demonstrated that using a mixture of probiotics ( Lactobacillus , Lactococcus , Bifidobacterium , Propionibacterium and Acetobacter ) enhanced ulcer healing by restoring the balance between pro- and anti-oxidants in the gastric mucosa ( 137 ). In addition, probiotic mixtures (comprising Bifidobacterium animalis VKL and VKB with or without Lactobacillus casei IMVB-7280) enhanced the recovery of stress hormones (adrenocorticotropin and corticosterone), decreased proinflammatory cytokines and increased anti-inflammatory cytokines ( 138 ).…”

Section: Prophylactic and Therapeutic Effects Of Probiotics In Gastrimentioning

confidence: 99%

Potential role of probiotics in the management of gastric ulcer

Khoder

Al-Menhali

Al-Yassir

et al. 2016

Experimental and Therapeutic Medicine

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Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibitors and antibiotics are commonly used to treat gastric ulcer. However, in the last few decades, the accumulating evidence for resistance to antibiotics and the side effects of antibiotics and acid inhibitors have drawn attention to the possible use of probiotics in the prevention and treatment of gastric ulcer. Probiotics are live microorganisms that when administered in adequate amounts confer health benefits on the host. Currently, the available experimental and clinical studies indicate that probiotics are promising for future applications in the management of gastric ulcers. This review aims to provide an overview of the general health benefits of probiotics on various systemic and gastrointestinal disorders with a special focus on gastric ulcer and the involved cellular and molecular mechanisms: i) Protection of gastric mucosal barrier; ii) upregulation of prostaglandins, mucus, growth factors and anti-inflammatory cytokines; iii) increased cell proliferation to apoptosis ratio; and iv) induction of angiogenesis. Finally, some of the available data on the possible use of probiotics in H. pylori eradication are discussed.

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Section: Prophylactic and Therapeutic Effects Of Probiotics In Gastrimentioning

confidence: 99%

Potential role of probiotics in the management of gastric ulcer

Khoder

Al-Menhali

Al-Yassir

et al. 2016

Experimental and Therapeutic Medicine

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“…Some probiotics have not only preventive effects but also therapeutic effects by promoting epithelial cell growth [ 100 ] and angiogenesis [ 101 ] and upregulating the expression of anti-inflammatory cytokines [ 102 ]. Therefore, the addition of probiotics to patients undergoing radical treatment for H. pylori can prevent gastritis caused by other microorganisms [ 49 ].…”

Section: Microorganism and The Treatment Of Gastric Diseasementioning

confidence: 99%

“…The beneficial effects of probiotic bacteria on host microbial environment may be due to their potential impact on the digestive tract microbial community and the intestinal immune system, including their ability to compete with intestinal pathogens, increase the secretion of Immunoglobin A (IgA), regulate the expression and secretion of cytokine, stimulate mucin, bacteriocins, and lactic acid production, and adjust the microbiota growth [97][98][99]. Some probiotics have not only preventive effects but also therapeutic effects by promoting epithelial cell growth [100] and angiogenesis [101] and upregulating the expression of anti-inflammatory cytokines [102]. Therefore, the addition of probiotics to patients undergoing radical treatment for H. pylori can prevent gastritis caused by other microorganisms [49].…”

Section: Microorganism and The Treatment Of Gastric Diseasementioning

confidence: 99%

Role of Gastric Microorganisms Other than Helicobacter pylori in the Development and Treatment of Gastric Diseases

Duan

Chen

et al. 2022

BioMed Research International

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The microenvironment in the stomach is different from other digestive tracts, mainly because of the secretion of gastric acid and digestive enzymes, bile reflux, special mucus barrier, gastric peristalsis, and so on, which all contribute to the formation of antibacterial environment. Microecological disorders can lead to gastric immune disorders or lead to the decrease of dominant bacteria and the increase of the abundance and virulence of pathogenic microorganisms and then promote the occurrence of diseases. The body performs its immune function through innate and adaptive immunity and maintains microbial balance through the mechanism of immune homeostasis. Microecological imbalance can lead to the invasion of pathogenic microorganisms and damage mucosal barrier and immune system. The coexistence of gastric microorganisms (including viruses and fungi) may play a synergistic or antagonistic role in the pathogenesis of gastric diseases. Probiotics have the ability to compete with intestinal pathogens, increase the secretion of immunoglobulin A (IgA), stimulate the production of mucin, bacteriocin, and lactic acid, regulate the expression and secretion of cytokines, and regulate the growth of microbiota, which all have beneficial effects on the host microbial environment. At present, most studies focused on Helicobacter pylori, ignoring other stomach microbes and the overall stomach microecology. So, in this article, we reviewed advances in human gastric microecology, the relationship between gastric microecology and immunity or gastric diseases, and the treatment of probiotics in gastric diseases, in order to explore new area for further study of gastric microorganisms and treatment of gastric diseases.

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“…Одним з перспективних напрямків вважають застосування природних ворогів патогенних бактерій -пробіотиків. Вони здатні діяти проти збудників захворювань, підвищувати загальну резистентність макроорганізму, впливати на функції імунокомпетентних клітин, стимулювати та відновлювати корисну мікрофлору тощо [1]. Ще одна серйозна проблема -недо-статня ефективність традиційних клітинних пробіотиків, теж потребує якнайшвидшого вирішення.…”

Section: вступunclassified