Effect of Pharmaceutically Acceptable Glycols on the Stability of the Liquid Crystalline Gels Formed by Poloxamer 407 in Water

Ivanova, R. S.; Lindman, Björn; Alexandridis, Paschalis

doi:10.1006/jcis.2002.8417

Cited by 94 publications

(83 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, the micellization and gelation transitions could be influenced by the presence of hydrophobic drug solutes: the hydrophobicities of various molecules have been demonstrated to affect Poloxamer 407 phase behavior [9] and liquid to gel transition [10].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

View full text Add to dashboard Cite

Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or packing. This property enables drugs to be mixed in the sol state at room temperature then the solution can be injected into a target tissue, forming a gel depot in-situ at body temperature with the goal of providing drug release control. The presence of micellar structures that give rise to thermoreversible gels, characterized by low toxicity and mucomimetic properties, makes this delivery system capable of solubilizing water-insoluble or poorly soluble drugs and of protecting labile molecules such as proteins and peptide drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers, which are commercial available amphiphilic polymers as Pluronic and Poloxemer, are widely used as dispersion stabilizers [1,2], pharmaceutical ingredients [3][4][5], biomedical materials [6,7] and templates for the synthesis of mesoporous materials [8][9][10][11] and nanoparticles [12][13][14][15][16][17][18][19]. This is due to a variety of PEO-PPO-PEO block copolymer self-assemblies tuned by molecular characteristics, concentration and temperature in the presence of selective solvents such as water [20,21].…”

Section: Introductionmentioning

confidence: 99%

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

Sakai

Kurosawa

Okada

et al. 2011

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Fabrication of vesicles with the diameter of 4-30 m was achieved by mixing of a hydrophobic nonionic surfactant (Span 65) with a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (Pluronic P123) in aqueous solutions at room temperature. Ring-shaped structure of the Pluronic P123/Span 65 mixture assemblies was confirmed by fluorescence microscopy. The presence of internal aqueous phase in the Pluronic P123/Span 65 mixture assemblies was determined by measuring the entrapment efficiency of calcein using fluorescence spectroscopy. On the other hand, Pluronic P123/Span 60 mixture system formed wire-like assemblies but not vesicles.

show abstract

“…The interfacial curvature is defined as positive when the interface bends toward the apolar domains-that is, the micelles are surrounded by the polar domains confining the apolar domains inside them, and vice versa. 30,31 In the cubic phase, interfacial curvature is highly positive because of the spherically shaped micelles. The normal hexagonal phase has been obtained at a high content of pluronic F 127 because of decreased solvation of the PEO blocks.…”

Section: Resultsmentioning

confidence: 99%

Development of tetracycline-serratiopeptidase-containing periodontal gel: Formulation and preliminary clinical study

et al. 2006

View full text Add to dashboard Cite

The purpose of this research was to reduce the polymer concentration and to obtain reasonable viscosity at a lower concentration of pluronic by the addition of a viscosity modifier. A 20% wt/wt pluronic gel was prepared on a weight basis using the cold method. The effect of the amount of tetracycline and Aerosil on gel properties was studied. The gel was evaluated using different parameters: polarizing microscopy, gelation, gel melting, bioadhesivity, viscosity, drug release, and stability of enzyme. An in vivo study was performed to evaluate the clinical efficiency of the liquid crystalline gel. Addition of Aerosil to the gel favored hexagonal phase formation. Viscosity and bioadhesivity increased with an increase in the concentration of Aerosil. Release of tetracycline was sustained as the concentration of Aerosil increased. Various clinical parameters confirmed the acceptability and efficiency of this gel system.

show abstract

Effect of Pharmaceutically Acceptable Glycols on the Stability of the Liquid Crystalline Gels Formed by Poloxamer 407 in Water

Cited by 94 publications

References 47 publications

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

Development of tetracycline-serratiopeptidase-containing periodontal gel: Formulation and preliminary clinical study

Contact Info

Product

Resources

About