Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

Abstract

Fabrication of vesicles with the diameter of 4-30 m was achieved by mixing of a hydrophobic nonionic surfactant (Span 65) with a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (Pluronic P123) in aqueous solutions at room temperature. Ring-shaped structure of the Pluronic P123/Span 65 mixture assemblies was confirmed by fluorescence microscopy. The presence of internal aqueous phase in the Pluronic P123/Span 65 mixture assemblies was determined by measuring the entrapment efficiency of calcein using fluorescence spectroscopy. On the other hand, Pluronic P123/Span 60 mixture system formed wire-like assemblies but not vesicles.

Nonionic surfactant-based vesicular system for transdermal drug delivery

“…A number of researchers also investigated TweensTM as nonionic surfactants in niosomes formations. Tweens are polysorbates derived from PEGylated sorbitan esterified with fatty acids (Fang et al, 2001b;Manosroi et al, 2003;Liu et al, 2007;Di Marzio et al, 2011;Kumar & Rajeshwarrao, 2011;Sakai et al, 2011;Junyaprasert et al, 2012).…”

Enhanced Skin Permeation of Punicalagin after Topical Application of Pluronic Micelles or Vesicles Loaded with Lafoensia pacari Extract

“…1S, Supporting Information). Sakai et al [21] had already described the change in formulation turbidity with the addition of Span 65, observed when the vesicular systems were obtained. Optical microscopy and laser diffraction analysis demonstrated that P25+Sp80 and P35+Sp80 presented micrometric structures with an average size of 5 µm (Fig.…”

“…Some studies have reported that poloxamer can spontaneously organize itself in the form of vesicles, depending on the concentration of electrolytes, anionic surfactant, like sodium dodecyl sulfate [19], temperature [20], and inorganic salt (NaF) [19]. Moreover, Sakai et al [21] demonstrated that the combination of poloxamer (Pluronic P123) and Span 65 resulted in the spontaneous formation of vesicles in water. To date, there is no report about the combination of Pluronic 407 and Sp80.…”

Vesicular hydrogen silsesquioxane-mediated synthesis of nanocrystalline silicon dispersed in a mesoporous silica/suboxide matrix, with potential for electrochemical applications

“…Similarly, other investigators prepared large vesicles by the conventional chloroform film method, mixing P-123 with a non-ionic surfactant (Span 65); they concluded that the surfactant increased the volume of the PPO core, thereby increasing the critical packing parameter and driving vesicle formation. 33 We note that a stable colloid was not observed when NaCl (6 g/under our reaction conditions) was present. Instead, a precipitate was formed after one hour following the injection of TES.…”