Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Bonacucina, Giulia; Cespi, Marco; Mencarelli, Giovanna; Giorgioni, Gianfabio; Palmieri, Gianni

doi:10.3390/polym3020779

Cited by 104 publications

(51 citation statements)

References 120 publications

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“…It is well documented in the literature that both micellization and gelation depend on different factors, namely, temperature and polymer concentration. 24 This is consistent with the observation from rheological measurements that an increase in polymer concentration leads to an increase in viscosity but also a lowering of gelation temperature.…”

Section: Discussionsupporting

confidence: 92%

Inkjet‐Printed Alginate Microspheres as Additional Drug Carriers for Injectable Hydrogels

et al. 2016

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Local delivery of bioactive molecules to the inner ear via diffusion through the round window membrane is becoming an attractive approach to treat sensorineural hearing loss compared to systemic drug administration. Pluronics R (Lutrol F127) are a class of thermosensitive hydrogels that remain liquid prior to injection and rapidly gel under physiological conditions. They are, however, limited to short-term drug release due to rapid hydrolysis in aqueous solution. Therefore, the aim of this study was to investigate an approach, using an ink-jet printing system, to sustain the drug release by incorporating hydrogel microspheres within Lutrol F127. Various concentrations of Lutrol F127 and calcium chloride (CaCl 2 ) were examined by rheology to determine the optimum combinations to use for injection and then blended with inkjet-printed alginate microspheres. Drug release (FITC-Dextran) from Lutrol F127 alone reached completion in less than 24 h. Release from alginate spheres alone showed a burst release and reached 100% in 6 h. Interestingly, the incorporation of microspheres within Lutrol F127 allowed a more sustained release profile and a slower burst release. By varying the quantity of microspheres, concentration of alginate, or ionic cross-linking ratio, the release profile can be adjusted to suit the desired application. C

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Section: Discussionsupporting

confidence: 92%

Inkjet‐Printed Alginate Microspheres as Additional Drug Carriers for Injectable Hydrogels

et al. 2016

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“…The micelle size was found to be consistent over a 6-month monitoring period, indicating long term stability under a freeze storage condition of 1˚C. As Pluronic F127 was prepared in dilute solution above its critical micelle concentration (CMC) and critical micelle temperature (CMT), it is ensured that no gelation occurred and that it forms self-assembling, non-aggregating micelles in adequate concentration and proper suspension in PBS [30]. Its hydrophobic PEO blocks associate to form the core region, whereas the hydrophilic PPO segments position between the core and the external aqueous medium, serving as an interface between the bulk PBS and the hydrophobic domain.…”

Section: Characterisation Of Polymeric Micelles (Pluronic F127) Beformentioning

confidence: 88%

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Aw¹,

Gulati²,

Lošić³

2011

JBNB

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Titania nanotube arrays (TNT) prepared by self-ordering electrochemical anodization have attracted considerable attention for the development of new devices for local drug delivery applications. Two approaches to extend drug release of water insoluble drugs by integrating TNTs with polymeric micelles and biopolymer coatings are presented in this work. The proposed strategies emphasized on remarkable properties of these materials and their unique combination to design local drug delivery system with advanced performance. The first concept integrates TNTs with drug loaded polymeric micelles (Pluronic F127) as drug nanocarrier, until the second concept includes polymer coating of drug loaded TNT with biodegradable polymer (chitosan). The water insoluble, anti-inflammatory drug, indomethacin was used as a model drug. Both approaches showed a significant improvement of the drug release characteristics, withreduced burst release (from 77% to 39%) and extended overall release from 9 days to more than 28 days. These results suggest the capability of TNT based systems to be applied for local drug delivery deliver over an extended period with predictable kinetics that is particularly important for bone implant therapies.

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“…Various drugs have been loaded in PLGA nanoparticles such as paclitaxel (18), curcumin (19), clarithromycin (20), praziquantel (21), doxorubicin (22,23), streptomycin (24) and siRNA (25). PEG-PLGA nanoparticles have been characterized (26)(27)(28) and tested for their loading capacity with various drugs as tumour necrosis factor alpha blocking peptide (29), isoniazid (30) and roxithromycin (31).…”

Section: Introductionmentioning

confidence: 99%

Probing the interaction of nanoparticles with mucin for drug delivery applications using dynamic light scattering

Griffiths

Cattoz

Ibrahim

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Drug delivery via the eye, nose, gastrointestinal tract and lung are of great interest as they represent patient-compliant and facile methods to administer drugs. However, for a drug to reach the systemic circulation it must penetrate the "mucus barrier". An understanding of the characteristics of the mucus barrier is therefore important in the design of mucus penetrating drug delivery vehicles e.g. nanoparticles. Here, a range of nanoparticles -silica, aluminium coated silica, poly (lactic-co-glycolic acid) (PLGA) and PEGylated PLGA -each with known but different physicochemical characteristics were examined in the presence of mucin to identify those characteristics that engender nanoparticle/mucin interactions and thus, to define "design rules" for mucus penetrating (nano) particles (MPP), at least in terms of the surface characteristics of charge & hydrophilicity. Dynamic light scattering (DLS) and rheology have been used to assess the interaction between such nanoparticles and mucin. It was found that negatively charged and hydrophilic nanoparticles do not exhibit an interaction with mucin whereas positively charged and hydrophobic nanoparticles show a strong interaction. Surface grafted poly (ethylene glycol) (PEG) chains significantly reduced this interaction. This study clearly demonstrates that the established colloid science techniques of DLS and rheology are very powerful screening tools to probe nanoparticle/mucin interactions.

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Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Cited by 104 publications

References 120 publications

Inkjet‐Printed Alginate Microspheres as Additional Drug Carriers for Injectable Hydrogels

Inkjet‐Printed Alginate Microspheres as Additional Drug Carriers for Injectable Hydrogels

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Probing the interaction of nanoparticles with mucin for drug delivery applications using dynamic light scattering

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