Effect of particle size on the in vitro bioactivity, hydrophilicity and mechanical properties of bioactive glass-reinforced polycaprolactone composites

Tamjid, Elnaz; Bagheri, Reza; Vossoughi, M.; Simchi, A.

doi:10.1016/j.msec.2011.06.013

Cited by 97 publications

(77 citation statements)

References 33 publications

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“…On the other hand, the water droplet can be spread easier on the more porous surface of membrane, which results in higher hydrophilicity [41]. It was previously shown that bioactive glass particles, as a hydrophilic material, remarkably improve the hydrophilicity of PCL matrix [9,18]. Nevertheless, a more pronounced effect was observed for composites containing smaller bioactive glass particles due to their homogenous distribution in the PCL matrix and thus uniform exposition on the surfaces [42,43].…”

Section: Discussionmentioning

confidence: 99%

“…Poly(ε-caprolactone) (PCL)-based composites reinforced with bioactive glass particles have been drawing increasing interest as materials for BTE applications [9,18]. Such composites combine excellent biocompatibility, relatively high mechanical strength, ease of processing, as well as low degradation rate of PCL [9,[18][19][20] with excellent bone-bonding ability, osteoconductive and/or osteoinductive character, stiffness and high hydrophilicity of bioactive glasses [8,9,18,21,22].…”

Section: Introductionmentioning

confidence: 99%

“…Such composites combine excellent biocompatibility, relatively high mechanical strength, ease of processing, as well as low degradation rate of PCL [9,[18][19][20] with excellent bone-bonding ability, osteoconductive and/or osteoinductive character, stiffness and high hydrophilicity of bioactive glasses [8,9,18,21,22]. Furthermore, there is a possibility to use sol-gel-derived glass particles that have a larger surface area and -OH groups present in their structure, and therefore usually exhibit higher bioactivity than conventional melt-derived glasses [23,24].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Poly(ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties

Dziadek¹,

Zagrajczuk²,

Menaszek

et al. 2017

J Mater Sci

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In contrast to currently used materials, membranes for the treatment of bone defects should actively promote regeneration of bone tissue beyond their physical barrier function. What is more, both material properties and biological features of membranes should be easily adaptable to meet the needs of particular therapeutic applications. Therefore, the role of preparation methods (nonsolvent-induced phase separation and thermal-induced phase separation) of poly(ε-caprolactone)-based membranes and their modification with gel-derived bioactive glass (BG) particles of two different sizes (\45 and \3 μm) in modulating material morphology, polymer matrix crystallinity, surface wettability, kinetics of in vitro bioactivity and also osteoblast response was investigated. Both surfaces of membranes were characterised in terms of their properties. Our results indicated a possibility to modulate microstructure (pore size ranging from submicron to hundreds of micrometres), wettability (from hydrophobic to fully wettable surface) and polymer crystallinity (from 19 to 60%) in a wide range by the use of various preparation methods and different BG particle sizes. Obtained composite membranes showed excellent in vitro hydroxyapatite forming ability after incubation in simulated body fluid. Here we demonstrated that bioactive layer formation on the surface of membranes occurred through ACP-OCP-CDHA-HCA transformation, that mimic in vivo bone biomineralization process. Composite membranes supported human osteoblast proliferation, stimulated cell differentiation and matrix mineralization. We proved that kinetics of bioactivity process and also osteoinductive properties of membranes can be easily modulated with the use of proposed variables. This brings new

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Poly(ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties

Dziadek¹,

Zagrajczuk²,

Menaszek

et al. 2017

J Mater Sci

View full text Add to dashboard Cite

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“…Poly(e-caprolactone) [26][27][28] Low chemical versatility; degradable by hydrolysis or bulk erosion; slow degrading; bioresorbable Polymethylmethacrylate (PMMA) [29][30][31] Brittle; biocompatible; thermoplastic; low ductility; used as bone cement [54][55][56] Carbonaceous nanophase in a ceramic or polymer matrix 50,57 Better osteoconductivity; tailorable degradation rate; enhanced mechanical and biological properties; supporting cell activity Metallic nanophase in a ceramic or polymer matrix [58][59][60] Polymer-polymer composites 61,62 Abbreviations: 2D, two-dimensional; 3D, three-dimensional; UFG, ultrafine-grained; CNT, carbon nanotube; CNF, carbon nanofiber. 63 Current challenges are related to engineering materials that can match both the mechanical and biological context of real bone tissue matrix and support the vascularization of large tissue constructs while restoring its physiological function.…”

Section: Challenges In Bone Tissue Engineering and Requirementsmentioning

confidence: 99%

“…Deposition of glycidyl methacrylate (GMA) nanolayer on the surface of Ti improves cellular attachment. 110 Various polymer-based nanocomposites such as PCL/TiO 2 , 26 PCL/n-BG, 27 CS/BG, 111 polymer/HA, 56 and polymer/calcium phosphate 8 have been examined and shown to possess improved bioactivity, enhanced mechanical properties, and better osteoconductivity. Many studies have also focused on utilizing carbon nanostructures as orthopedic implants coatings.…”

Section: Nanostructured Coatingsmentioning

confidence: 99%

Nanomedicine applications in orthopedic medicine: state of the art

Mazaheri¹,

Eslahi²,

Ordikhani³

et al. 2015

IJN

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The technological and clinical need for orthopedic replacement materials has led to significant advances in the field of nanomedicine, which embraces the breadth of nanotechnology from pharmacological agents and surface modification through to regulation and toxicology. A variety of nanostructures with unique chemical, physical, and biological properties have been engineered to improve the functionality and reliability of implantable medical devices. However, mimicking living bone tissue is still a challenge. The scope of this review is to highlight the most recent accomplishments and trends in designing nanomaterials and their applications in orthopedics with an outline on future directions and challenges.

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Progress on Electrospun Composite Fibers Incorporating Bioactive Glass: An Overview

et al. 2023

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Electrospinning is a promising approach for the development of fibrous tissue engineering (TE) scaffolds suitable for hard and soft tissues. Apart from physicomechanical properties, electrospun fibers are required to incorporate bioactive cues to control cellular functions, including facilitating biomineralization and osteogenic differentiation in case of bone TE, as well as vascularization, to support successful tissue regeneration. In recent years, bioactive glass (BG) addition to electrospun biopolymer fibers has shown promising results in enhancing the properties of fibers, including the improvement of biological performance. In this article, a comprehensive overview of BG‐containing electrospun polymer composite fibers is presented, identifying the parameters that affect the mechanical properties as well as the biological response in vivo and in vitro. Subsequently, the effects of BG addition on the properties of the scaffolds are discussed. Recent developments in the fields of bone regeneration, wound healing, and drug delivery using BG‐containing electrospun fibrous scaffolds are described in detail. Essential aspects related to BG‐polymer composite fibers for translational research in TE are highlighted for future research in this field.

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Effect of particle size on the in vitro bioactivity, hydrophilicity and mechanical properties of bioactive glass-reinforced polycaprolactone composites

Cited by 97 publications

References 33 publications

Poly(ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties

Poly(ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties

Nanomedicine applications in orthopedic medicine: state of the art

Progress on Electrospun Composite Fibers Incorporating Bioactive Glass: An Overview

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