Progress on Electrospun Composite Fibers Incorporating Bioactive Glass: An Overview

Ghorbani, Farnaz; Reiter, Theresa; Liverani, Liliana; Schubert, Dirk; Boccaccını, Aldo R.; Roether, Judith A.

doi:10.1002/adem.202201103

Cited by 2 publications

(1 citation statement)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In many studies, usually BGs in particulate form are incorporated in a polymeric matrix, and the composite solution is electrospun into nanofiber mats [26][27][28]. Indeed, the incorporation of BG nano and microparticles in polymers for electrospinning has found considerable interest in recent years, as reviewed recently [29].…”

Section: Introductionmentioning

confidence: 99%

Processing and characterization of aligned electrospun gelatin/polycaprolactone nanofiber mats incorporating borate glass (13-93B3) microparticles

Ege,

Pourshahrestani,

Iorio

et al. 2023

Biomed. Mater.

Self Cite

View full text Add to dashboard Cite

Aligned biodegradable fibers incorporating bioactive glass particles are being highly investigated for tissue engineering applications. In this study, 5, 7 and 10 wt% melt-derived 1393B3 borate glass (BG) microparticles (average size of 3.15 µm) were incorporated in 83 wt% PCL and 17 wt% gelatin (83PCL/17GEL) solutions to produce aligned electrospun composite nanofiber mats. Addition of 5 wt% BG particles significantly increased the alignment of the nanofibers. However, further incorporation of BG particles led to reduced degree of alignment, likely due to an increase of viscosity. Mechanical tests indicated a tensile modulus and tensile strength of approximately 51 MPa and 3.4 MPa, respectively for 5 wt% doping of 1393B3 BGs, values considered suitable for soft tissue engineering applications. However, with the increasing amount of 1393B3 BG, the nanofiber mats became brittle. Contact angle was reduced after the addition of 5 wt% of 1393B3 BG particles from ∼45° to ∼39°. Cell culture studies with normal human dermal fibroblast (NHDF) cells indicated that 5 wt% 1393B3 BG incorporated nanofiber mats were cytocompatible whereas higher doping with 1393B3 BGs reduced biocompatibility. Overall, 5 wt% 1393B3 BG doped PCL/GEL nanofiber mats were aligned with high biocompatibility exhibiting desirable mechanical properties for soft tissue engineering applications, which indicates their potential for applications requiring aligned nanofibers, such as peripheral neural regeneration.

show abstract