Effect of parabiosis of young and old rats on aortic calcification and collagen cross-links

Hruza, Z; Hlaváčková, V.

doi:10.1016/0531-5565(67)90016-2

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Biochemical activities such as Ca 2+ uptake by the aorta, cholesterol transfer from the serum to the aorta and muscle, or collagenase activity in old rats after parabiosis with young rats seemed to shift closer to those in young control rats, while the activities in the young partner rats remained at the levels of the young controls (9)(10)(11). On the other hand, histological characteristics such as hepatic cell size and number in young rats after parabiosis with old rats shifted closer to those in old control rats, and those in old partner rats shifted to those in young controls (12,13).…”

Section: Discussionmentioning

confidence: 60%

“…Young-old parabiotic rats have been used in experiments to elucidate age-related changes in old rats (9)(10)(11)(12)(13). Biochemical activities such as Ca 2+ uptake by the aorta, cholesterol transfer from the serum to the aorta and muscle, or collagenase activity in old rats after parabiosis with young rats seemed to shift closer to those in young control rats, while the activities in the young partner rats remained at the levels of the young controls (9)(10)(11).…”

Section: Discussionmentioning

confidence: 74%

“…Parabiosis technique has been used in the study of the humoral transmission of many substances including hormones (7) and factors relating to aging (8)(9)(10)(11)(12)(13) or immunity (14,15). If the alterations in bile acid metabolism are caused by the age-related changes in humoral factors, the increase in CA synthesis or the decrease in CDCA synthesis in aged rats will be prevented by the parabiosis with young rats, or the bile acid metabolism in young rats will be shifted to an aged state after parabiosis with old rats.…”

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confidence: 99%

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Bile acid metabolism in young‐old parabiotic rats

Uchida

Takase

Nomura

et al. 1997

Lipids

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Serum cholesterol, triglyceride and phospholipid levels, liver cholesterol concentration, bile flow, biliary cholesterol, phospholipid and bile acid secretion rates, fecal sterol and bile acid levels and their bile acid compositions were examined in young-old parabiotic rats and compared with those in young and old control rats and young-young parabiotic rats. Bile acid composition was expressed in terms of the cholic acid group/chenodeoxycholic acid group (CA/CDCA) ratio. Body weight (BW) gain decreased after parabiosis especially in old rats, but the liver weight (g/100 g BW), diet-intake, feces dry weight, liver cholesterol concentration and fecal sterol level were almost the same in all the groups. The biliary bile acid secretion rate was higher and the fecal bile acid level was lower in old rats than those in young rats but both the levels became comparable with those in young rats after parabiosis of old rats with young rats. Young rats, however, showed no changes in these levels after parabiosis. The serum cholesterol level and the biliary and fecal CA/CDCA ratios in old rats were higher than those in young rats but decreased after parabiosis with young rats, although they were still higher than those in young rats. The serum cholesterol level in young rats increased after parabiosis with old rats, but not after parabiosis with young rats, and the fecal bile acid level and the CA/CDCA ratio were not changed in either case. It is concluded from these findings that the serum cholesterol level and the CA/CDCA ratio increased with age and that these increases were prevented after parabiosis with young rats while young rats, although their serum cholesterol level was increased, showed no increase in the CA/CDCA ratio after parabiosis with old rats.

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