Change of the hepatic cells in parabiosis between old and young rats

Tauchi, Hisashi; Hasegawa, Katsumi

doi:10.1016/0047-6374(77)90034-3

Cited by 21 publications

(7 citation statements)

References 8 publications

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“…Historically, this has been used to explore age-related physiological and pathological changes (Finerty, 1952; Tauchi and Hasegawa, 1977) and even longevity (McCay et al, 1957). Recently, heterochronic parabiosis (Figure 1) has been used to test whether tissue-specific stem cells (i.e., stem cells that are not pluripotent but are already committed to a specific germ layer or even a specific tissue) from old mice could be rejuvenated by exposure to a young environment (Conboy et al, 2005).…”

Section: Rejuvenation Without Dedifferentiationmentioning

confidence: 99%

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

Rando

Chang

2012

Cell

466

357

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The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges.

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Section: Rejuvenation Without Dedifferentiationmentioning

confidence: 99%

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

Rando

Chang

2012

Cell

466

357

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“…Early evidence came from a surgical procedure called heterochronic parabiosis, wherein the circulatory system of a young animal is coupled to that of an aged animal (Figure 1). This procedure can rejuvenate a number of organs in the older of the pair [1][2][3]. The provision of young blood even enhances cognitive performance in aged mice by improving synaptic plasticity in the hippocampus [4].…”

mentioning

confidence: 99%

An ingredient for the elixir of youth

Andersen¹,

Lim²

2014

Cell Res

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“…Biochemical activities such as Ca 2+ uptake by the aorta, cholesterol transfer from the serum to the aorta and muscle, or collagenase activity in old rats after parabiosis with young rats seemed to shift closer to those in young control rats, while the activities in the young partner rats remained at the levels of the young controls (9)(10)(11). On the other hand, histological characteristics such as hepatic cell size and number in young rats after parabiosis with old rats shifted closer to those in old control rats, and those in old partner rats shifted to those in young controls (12,13).…”

Section: Discussionmentioning

confidence: 36%

“…Young-old parabiotic rats have been used in experiments to elucidate age-related changes in old rats (9)(10)(11)(12)(13). Biochemical activities such as Ca 2+ uptake by the aorta, cholesterol transfer from the serum to the aorta and muscle, or collagenase activity in old rats after parabiosis with young rats seemed to shift closer to those in young control rats, while the activities in the young partner rats remained at the levels of the young controls (9)(10)(11).…”

Section: Discussionmentioning

confidence: 76%

“…Parabiosis technique has been used in the study of the humoral transmission of many substances including hormones (7) and factors relating to aging (8)(9)(10)(11)(12)(13) or immunity (14,15). If the alterations in bile acid metabolism are caused by the age-related changes in humoral factors, the increase in CA synthesis or the decrease in CDCA synthesis in aged rats will be prevented by the parabiosis with young rats, or the bile acid metabolism in young rats will be shifted to an aged state after parabiosis with old rats.…”

mentioning

confidence: 99%

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Bile acid metabolism in young‐old parabiotic rats

Uchida

Takase

Nomura

et al. 1997

Lipids

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Serum cholesterol, triglyceride and phospholipid levels, liver cholesterol concentration, bile flow, biliary cholesterol, phospholipid and bile acid secretion rates, fecal sterol and bile acid levels and their bile acid compositions were examined in young-old parabiotic rats and compared with those in young and old control rats and young-young parabiotic rats. Bile acid composition was expressed in terms of the cholic acid group/chenodeoxycholic acid group (CA/CDCA) ratio. Body weight (BW) gain decreased after parabiosis especially in old rats, but the liver weight (g/100 g BW), diet-intake, feces dry weight, liver cholesterol concentration and fecal sterol level were almost the same in all the groups. The biliary bile acid secretion rate was higher and the fecal bile acid level was lower in old rats than those in young rats but both the levels became comparable with those in young rats after parabiosis of old rats with young rats. Young rats, however, showed no changes in these levels after parabiosis. The serum cholesterol level and the biliary and fecal CA/CDCA ratios in old rats were higher than those in young rats but decreased after parabiosis with young rats, although they were still higher than those in young rats. The serum cholesterol level in young rats increased after parabiosis with old rats, but not after parabiosis with young rats, and the fecal bile acid level and the CA/CDCA ratio were not changed in either case. It is concluded from these findings that the serum cholesterol level and the CA/CDCA ratio increased with age and that these increases were prevented after parabiosis with young rats while young rats, although their serum cholesterol level was increased, showed no increase in the CA/CDCA ratio after parabiosis with old rats.

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Change of the hepatic cells in parabiosis between old and young rats

Cited by 21 publications

References 8 publications

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

An ingredient for the elixir of youth

Bile acid metabolism in young‐old parabiotic rats

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