2006
DOI: 10.2174/157340206775473757
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Abstract: Immune dysfunction has been reported in patients with hypertension and in spontaneously hypertensive rats. Increased circulating levels of ouabain were observed in experimental models and in human hypertension. Despite the correlation between immunologic depression and hypertension, the mechanisms involved are unclear. This review examines evidences of immune dysfunction in hypertension and presents observations suggesting that ouabain is capable of inducing lymphocyte changes related to some of the immune dis… Show more

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Cited by 4 publications
(6 citation statements)
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“…Ouabain has been proposed to act as a neuroregulator, 19–26 and we now extend its role as an immunomodulator 27 …”
Section: Introductionmentioning
confidence: 78%
“…Ouabain has been proposed to act as a neuroregulator, 19–26 and we now extend its role as an immunomodulator 27 …”
Section: Introductionmentioning
confidence: 78%
“…Evidence suggests that low concentrations of ouabain can regulate several events in cells belonging to the immune system (Echevarria-Lima and Rumjanek, 2006). Transduction of extracellular signals to intracellular targets is mediated by several protein kinases, including the MAPKs family.…”
Section: Discussionmentioning
confidence: 99%
“…This alternative pathway involves the protein Dlgh1 as an essential scaffold that assembles a module for activation of p38 (Round et al, 2007). Ouabain has been shown to modulate a number of cells from the immune system (Quastel and Kaplan, 1968;Brodie et al, 1995;Marakhova et al, 2005;Echevarria-Lima and Rumjanek, 2006) including thymocytes. Others have found in different cell types that p38 levels can be regulated by ouabain (Li and Wattenberg, 1998;Stathopoulou et al, 2006), probably through inhibition of the Na þ /K þ pump.…”
Section: Introductionmentioning
confidence: 99%
“…Important actions have also been ascribed to ouabain in the immune system [16] , suggesting that this hormone also works as an immunomodulator. Similar to observations in the CNS, the effects vary with cell type and the concentration used.…”
mentioning
confidence: 99%