Effect of oppositely charged polymer and dissolution medium on swelling, erosion, and drug release from chitosan matrices

Bhise, Kiran; Dhumal, Ravindra S.; Chauhan, Bhaskar; Paradkar, Anant; Kadam, Shivajirao

doi:10.1208/pt0802044

Cited by 48 publications

(39 citation statements)

References 37 publications

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“…In such cases other polymers can be added to strengthen the matrices. The previous research from our laboratory has provided evidence to support and confirm the importance of in-situ complexation between oppositely charged polyelectrolytes in the matrices containing physical mixtures of chitosan, carrageenan and naproxen sodium (5). The effects of such ionic interactions on water uptake, matrix erosion and inhibition of naproxen sodium release were evaluated in the different dissolution media (5).…”

Section: Introductionmentioning

confidence: 81%

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Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

et al. 2007

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Abstract. The purpose of this research was to explore theapplication of ionic interactions between naproxen sodium (NS) and chitosan (CH) in complexes (NSC) prepared by tray drying (TD) and spray drying (SD) methods. Drug-polymer ratio (1:1) in the NSC was optimized on the basis of dialysis studies. The particulate systems of NSC were prepared by tray drying (TD) and spray drying (SD) methods. Release retarding polymers were added to the NSC and to the physical mixtures containing NS-CH and their effects on water uptake, matrix erosion and drug release at different pH were compared. Spray dried complexes (SDC) were spherical, free flowing, light and fine amorphous particles in contrast to the crystalline, hard, tenacious, irregularly shaped, denser tray dried complexes (TDC) with poor flowability. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and Fourier transform infrared (FTIR) patterns confirm the conversion of crystalline to high energy amorphous phase suitable for ionic interactions in NSC. Presence of release retarding polymers, kappa carrageenan and hydroxypropylmethylcellulose (HPMC) in the NSC compacts retarded the drug release and improved the matrix integrity. Carrageenan matrices exhibited more retardation than HPMC tablets. FTIR patterns, erosion, swelling and drug release from matrices support ionic interactions between NS and CH in NSC. The reasons for retarded drug release from the chitosan matrices at acidic pH include poor solubility of drug at acidic pH, formation of a rate limiting polymer gel barrier along the periphery of matrices and the ionic interactions between oppositely charged moieties.

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Section: Introductionmentioning

confidence: 81%

“…Drug-polyelectrolyte complexation can be explored as one of the techniques in formulating sustained release dosage forms. Stable complexes between drug-polymers have been reported in the literature (1)(2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

et al. 2007

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“…CH is a natural polymer but has low or no solubility in aqueous solution but is conveniently soluble in dilute acids and possess favorable film forming properties [8]. -NH 3 + groups are existent in CH molecule in an ionized form while, -COO − groups are present in OFG.…”

Section: Resultsmentioning

confidence: 99%

“…Contrary to this, the property of CH being soluble in stomach acidic pH, efforts are put on derivatization or cross-linking it for amending drug release peculiarity [6,7]. The researchers have worked to enhance the film forming property of various polysaccharides such as chondroitin [8], sodium citrate [9], sodium alginate [10], and co-processing with CH. The drug delivery in colorectal drug release dosage forms [11], sustained release drug delivery systems [12] and transdermal film formulations [7], has been improved through these films.…”

Section: Introductionmentioning

confidence: 99%

Okra Fruit Gum-Chitosan Impregnated Polymer Network Films: Formulation and Substantial Depiction

Nagpal

Aggarwal

Jain

et al. 2017

Asian J Pharm Clin Res

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Objective: The present research is aimed at formulation and evaluation of okra fruit gum (OFG)-chitosan (CH) impregnated polymer network films. Methods:The film forming property of the gum attained from fruits of Abelmoschus esculentus was enhanced by co-processing it with CH. Estimation of properties including swelling index (SI), film volume, volume index, film surface contact angle with buffer solutions (pH 1.2, 7.4 or 6.8), work of adhesion (Wa), and spreading coefficient was done. Results:The contact angle and SI of OFG-CH film in both acidic and alkaline buffers were witnessed to be lowest when equated with the films prepared with difference in ratios of both gum and CH. Moreover, the Wa and spreading coefficient were less for this film. These results could be attributed to the optimum interaction between -COO − groups of gum and -NH3 + groups of CH. Conclusion:The actual nature of the film found to be tough, flexible, and water resistant. Hence, the results have shown that the films produced have a high potential for use in modified drug release and in food and pharmaceuticals.

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“…The 1,375 peak of sulfate groups of carrageenan disappeared, indicating the formation of an ionic bonding between NH 2 groups of famotidine and SO 4 − groups of carrageenan. A strong reduction in the intensity of the absorption band of SO 4 − groups of carrageenan was previously reported to be an indication of a strong interaction between the negatively charged carrageenan and the positively charged chitosan (37). In spite of the strong interaction confirmed by the absence of the SO 4 − groups peak of carrageenan, the observed slight shifts occurring in the amino groups peaks of famotidine might be due to the presence of the drug in its folded B polymorphic form (38) with subsequent decrease in some available amino groups for association with the studied polymer.…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 85%

Release Mechanisms Behind Polysaccharides-Based Famotidine Controlled Release Matrix Tablets

et al. 2008

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Abstract. Polysaccharides, which have been explored to possess gelling properties and a wide margin of safety, were used to formulate single-unit floating matrix tablets by a direct compression technique. This work has the aim to allow continuous slow release of famotidine above its site of absorption. The floating approach was achieved by the use of the low density polypropylene foam powder. Polysaccharides (κ-carrageenan, gellan gum, xyloglucan, and pectin) and blends of polysaccharides (κ-carrageenan and gellan gum) and cellulose ethers (hydroxypropylmethyl cellulose, hydroxypropylcellulose, sodium carboxymethyl cellulose) were tried to modulate the release characteristics. The prepared floating tablets were evaluated for their floating behavior, matrix integrity, swelling studies, in vitro drug release studies, and kinetic analysis of the release data. The differential scanning calorimetry and Fourier transform infrared spectroscopy studies revealed that changing the polymer matrix system by formulation of polymers blends resulted in formation of molecular interactions which may have implications on drug release characteristics. This was obvious from the retardation in drug release and change in its mechanistics.

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Effect of oppositely charged polymer and dissolution medium on swelling, erosion, and drug release from chitosan matrices

Cited by 48 publications

References 37 publications

Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

Okra Fruit Gum-Chitosan Impregnated Polymer Network Films: Formulation and Substantial Depiction

Release Mechanisms Behind Polysaccharides-Based Famotidine Controlled Release Matrix Tablets

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