Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

Bhise, Kiran; Dhumal, Ravindra S.; Paradkar, Anant; Kadam, Shivajirao

doi:10.1208/s12249-007-9001-0

Cited by 57 publications

(26 citation statements)

References 19 publications

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“…Literature reveals profound work which contributed in SR formulation design using natural polymers like xanthan gum (XG) (10), guar gum (11), chitosan (CP) (12), okra gum (13), and karaya gum (14,15). Oppositely charged natural polyelectrolytes like κ-carrageenan-chitosan, sodium alginate-chitosan, and poly(acrylic acid)-chitosan have also been utilized to retard the release of oppositely charged drugs (16)(17)(18)(19)(20). Some of the lucrative characteristics of natural polymers make them useful for extended drug delivery purpose are biocompatibility, inexpensiveness, wide availability, compatibility with drugs, physiological inertness, etc.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

2014

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Abstract. In the present work, an attempt has been made to screen Prosopis africana seed gum (PG), anionic polymer for extended release tablet formulation. Different categories of drugs (charge basis) like diclofenac sodium (DS), chlorpheniramine maleate (CPM), and ibuprofen (IB) were compacted with PG and compared with different polymers (charge basis) like xanthan gum (XG), hydroxypropyl methyl cellulose (HPMC-K100M), and chitosan (CP). For each drug, 12 batches of tablets were prepared by wet granulation technique, and granules were evaluated for flow properties, compressibility, and compactibility by Heckel and Leuenberger analysis, swelling index, in vitro dissolution studies, etc. It has been observed that granules of all batches showed acceptable flowability. According to Heckel and Leuenberger analysis, granules of PG-containing compacts showed similar and satisfactory compressibility and compactibility compared to granules of other polymers. PG showed significant swelling (P<0.05) compared to HPMC, and better than CP and XG. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) study showed no interaction between drugs and polymers. From all PG-containing compacts of aforesaid drugs, drug release was sustained for 12 h following anomalous transport. Especially, polyelectrolyte complex formation retarded the release of oppositely charged drug (CPM-PG). However, extended release was noted in both anionic (DS) and nonionic (IB) drugs, maybe due to swollen gel. All compacts were found to be stable for 3-month period during stability study. This concludes that swelling and release retardation of PG has close resemblance to HPMC, so it can be used as extended release polymer for all types of drugs.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

2014

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“…Slower drug release from SD1# as compared to SD2# was observed in all the media. The NS-CH and CH-κ-Ca ionic interactions contributed in sustaining the drug release (10). Overall release of NS at the acidic pH was less.…”

Section: Discussionmentioning

confidence: 94%

“…The previous research from our laboratory has provided evidence to confirm the in situ complexation in the matrices containing CH, κ-carrageenan (κ-Ca), and NS (9). The possibility of ionic interactions in NSC prepared by different drying techniques was further explored with κ-Ca and hydroxypropyl methylcellulose (HPMC) (K4), and their effect on water uptake, matrix erosion, and drug release in the different dissolution media were correlated (10). The NSC complexes and NS-CH ratios in the complexes were quantified and optimized based on the dialysis studies.…”

Section: Introductionmentioning

confidence: 89%

“…The NSC characterization, the evidence of charge presentation in the swollen gel matrices, and their dissolution profiles in the different media have been addressed. The drug dissolution of the NSC complexes at different pH was affected due to the addition of ionic and neutral release-retarding polymers in different concentrations (10). The literature reviews demonstrate the importance of polymer, the hydration, and interparticular forces on the drug dissolution at different pH.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Oppositely Charged Polymer and Dissolution Media on Rheology of Spray-Dried Ionic Complexes

et al. 2010

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Abstract. The purpose of this research was to address the utility of rheological study in understanding the influence of oppositely charged polymers on release of naproxen sodium encapsulated in chitosan particles. The interaction between oppositely charged κ-carrageenan (κ-Ca) and chitosan leads to relatively higher gel strength, which is proportional to the ability to retard the drug release at acidic pH. The oscillatory tests within the linear viscoelastic range where the stress is proportional to the applied strain were performed on the hydrated sample matrices containing chitosan-naproxen sodium spraydried complexes and k-Ca or hydroxypropyl methylcellulose (HPMC) in various ratios. It was observed that the effect of pH change on the dynamic moduli in spray-dried complexes containing κ-Ca was much stronger than that with HPMC reflecting presence of strong ionic interaction between κ-Ca and chitosan. The combination of oppositely charged polymers in different ratios proved to be useful in modulating the rheological properties of the hydrated formulations and their release-retarding properties. Dynamic moduli can be used to measure gel strength and are significant for the interpretation of oral sustained release spray-dried complexes.

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“…Previous research from our laboratory has provided an evidence to confirm the in situ complexation in the matrices containing CH, κ-carrageenan (κ-Ca), and NPX (11). The possibility of ionic interactions in CH and NPX complexes prepared by different drying techniques was further explored, and the characterization of ionic complexes, the evidence of charge presentation in the swollen gel matrices, and their dissolution profiles in the different media have been addressed (16). The influence of oppositely charged polymers and dissolution media on the rheology of hydrated matrices containing spray-dried NPX-CH complex (NPXF) has been addressed in our recent work (17).…”

Section: Introductionmentioning

confidence: 99%

Reduced Ulcerogenic Potential and Antiarthritic Effect of Chitosan–Naproxen Sodium Complexes

Ghosh

Bhise²,

Paradkar

et al. 2012

AAPS PharmSciTech

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Abstract. The purpose of this research was to address the utility of naproxen sodium-chitosan spray-dried complexes for antiulcer and antiarthritic activities. The cold stress technique was used to examine the ulcerogenic potential of naproxen sodium (NPX) and spray-dried formulations in the different doses. The ulcerations reduced with the dose of spray-dried complexes of naproxen sodium and chitosan. The conspicuous hemorrhagic lesions were visible in the morphological features of the animal treated with naproxen 50 mg/kg (p.o.). Thus, the results suggest that the spray-dried naproxen sodium-chitosan complex (NPXF) was not corrosive to the gastric mucosa at high doses of 50, 100, and 200 mg/kg (p.o.) under stressful conditions. It is evident from the present investigation that NPXF does not possess any ulcerogenic potential in comparison to naproxen which, under stressful conditions, led to the hypersecretion of HCl, culminating to petichial hemorrhages in the gastric mucosa of the animals. The biphasic pattern was observed in the various arthritic parameters. The rise in paw volume, joint diameter, WBC count, arthritis score, and fall in body weight was significantly ameliorated in the animals treated with NPXF (5, 10, and 20 mg/kg, p.o). At the end of the study, slight erythema was visible in the naproxen-treated animals. However, no erythema, redness, or ulcers were visible in the animals treated with NPXF. Thus, the direct compression properties and reduced ulcerogenic activity, combined with the demonstrated solubilizing power and analgesic effect enhancer ability toward the drug, make naproxen sodium-chitosan spray-dried complexes particularly suitable for developing a reduced-dose, fast-release, solid oral dosage form of naproxen.

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Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

Cited by 57 publications

References 19 publications

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

Effect of Oppositely Charged Polymer and Dissolution Media on Rheology of Spray-Dried Ionic Complexes

Reduced Ulcerogenic Potential and Antiarthritic Effect of Chitosan–Naproxen Sodium Complexes

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