Release Mechanisms Behind Polysaccharides-Based Famotidine Controlled Release Matrix Tablets

Abstract

Abstract. Polysaccharides, which have been explored to possess gelling properties and a wide margin of safety, were used to formulate single-unit floating matrix tablets by a direct compression technique. This work has the aim to allow continuous slow release of famotidine above its site of absorption. The floating approach was achieved by the use of the low density polypropylene foam powder. Polysaccharides (κ-carrageenan, gellan gum, xyloglucan, and pectin) and blends of polysaccharides (κ-carrageenan and gellan gum) and cellulose ethers (hydroxypropylmethyl cellulose, hydroxypropylcellulose, sodium carboxymethyl cellulose) were tried to modulate the release characteristics. The prepared floating tablets were evaluated for their floating behavior, matrix integrity, swelling studies, in vitro drug release studies, and kinetic analysis of the release data. The differential scanning calorimetry and Fourier transform infrared spectroscopy studies revealed that changing the polymer matrix system by formulation of polymers blends resulted in formation of molecular interactions which may have implications on drug release characteristics. This was obvious from the retardation in drug release and change in its mechanistics.

Pharmaceutical Approach to the Floating/Gastroretentive Systems in Stomach

“…Ayrıca, jel yapısı bir depo gibi hareket etmeye olanak tanıdığından, etkin madde jel bariyerden difüzyon ile veya matriks oluşturucu polimerin tipine göre belirginleşen çeşitli salım yolları ile yavaş yavaş salınmaktadır. [23][24][25] Ranitidin ve düşük dansiteli toz olarak polistiren divinilbenzen kullanılarak yüzen matriks tabletler çalışılmış, etkin maddenin salımı 8 saat uzatılmıştır. 26…”

Design and development of a reflective membrane for a novel Building Integrated Concentrating Photovoltaic (BICPV) ‘Smart Window’ system

“…[21] FTIR studies on bond stretching in HPC-gellan gum blends reported a shift in the O-H stretching peak to a higher wavenumber than observed for HPC or gellan gum alone, indicating that it is intermolecular hydrogen bonding being formed between HPC and gellan gum. [22] Although the Ts for various compositions of HPC-Gellan-NaCl membranes has been reported in the literature, [23] there is no systematic study on the transmittance/reflectance changes of the thermotropic layer under various compositions and temperature. This is critical for application in the Concentrating Photovoltaic 'Smart Window' System.…”

Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality

“…To overcome the uneven and incomplete oral absorption, various controlled release systems have been evaluated for drugs with moderate oral bioavailability, such as famotidine [63][64][65][66][67][68] and metformin [69][70][71][72][73][74][75]. As an example, Guan et al developed a novel gastro-retentive osmotic pump capsule using asymmetric membrane technology and obtained complete famotidine delivery and a zero-order release rate during floating on the medium [68].…”