Effect of Norplant contraceptive on the bones of Nigerian women as assessed by quantitative ultrasound and serum markers of bone turnover

VanderJagt, Dorothy J.; Sagay, Atiene S.; Imade, Godwin; Farmer, Stephanie E.; Glew, Robert H.

doi:10.1016/j.contraception.2005.04.013

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…The other 38 studies examined BMD (Tables 1 and 2). Thirty-two studies examined use of DMPA , eight reports of seven studies examined levonorgestrel implants [15,18,23,31,[39][40][41][42] and one study each examined etonogestrel implants [43], progestogen-only pills [44] and NET-EN [21]. We did not identify any studies that examined the effects of the levonorgestrel-releasing intrauterine system on fracture risk or BMD.…”

Section: Resultsmentioning

confidence: 99%

Progestogen-only contraception and bone mineral density: a systematic review

2006

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Questions have been raised about the effects of progestogen-only contraceptive use on bone health, particularly among young women who have not yet reached peak bone mass and perimenopausal women who may be starting to lose bone mass. We conducted a systematic review that evaluated the association between progestogen-only contraceptive use and fracture risk or bone mineral density (BMD). We identified 39 articles from MEDLINE and EMBASE, published through July 2005. One study reported that depot medroxyprogesterone acetate (DMPA) users were more likely to experience stress fractures than nonusers; this association was not statistically significant after controlling for baseline bone density. In cross-sectional studies, the mean BMD in DMPA users was usually below that of nonusers, but within 1 SD. In longitudinal studies, BMD generally decreased more over time among DMPA users than among nonusers, but women gained BMD upon discontinuation of DMPA. Limited evidence suggested that use of progestogen-only contraceptives other than DMPA did not affect BMD.

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Section: Resultsmentioning

confidence: 99%

Progestogen-only contraception and bone mineral density: a systematic review

2006

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“…By contrast, other POHC such as levonorgestrel appear to decrease bone turnover markers. Thus, a cross‐sectional study of 90 Nigerian women using levonorgestrel implants up to 4 years showed levels of serum BSAP and serum NTX‐I to be 40–60% lower than in nonuser controls 78 . The decrease in serum NTX‐I levels was significantly correlated with the duration of treatment, with the lowest serum NTX‐I concentrations seen in women using the implants for 4 years.…”

Section: Effects Of Hormonal Contraceptives On Bonementioning

confidence: 96%

The effects of hormonal contraceptives on bone turnover markers and bone health

Herrmann

Seibel

2010

Clinical Endocrinology

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SummarySex hormones are important regulators of bone metabolism. As hormonal contraceptives contain either oestrogens or progestins, or a combination thereof, it is conceivable that these widely used agents have an effect on bone metabolism and bone health. The main users of hormonal contraceptives, adolescent girls and young women, are still building bone and accruing bone mass and may therefore be particularly susceptible to the effects of hormonal contraceptives on bone. Despite these concerns, the effects of hormonal contraceptives on bone health are still poorly understood. As biochemical markers of bone turnover have been proven useful tools in the assessment and monitoring of bone metabolism, we reviewed the effects of combined and gestagen-only hormonal contraceptives on bone turnover markers and related effects on bone mineral density and fracture risk in premenopausal women, as

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“…The other study showed an increment of 2.4% at 1 year of use [79]. Other papers have found no statistically significant differences between users and nonusers with respect to BMD measured at the lumbar spine (L2-L4), femoral neck or distal radius [78,80,81] (for a review, see [56]). However, in the largest cross-sectional study carried out in 610 Norplant users and 695 nonusers, mean BMD at the midshaft of the ulna was lower among exclusive users of Norplant than among nonusers [34].…”

Section: Levonorgestrel-releasing Subdermal Implantmentioning

confidence: 94%

Does the use of hormonal contraceptives affect bone mineral density?

Bahamondes

2007

Expert Review of Obstetrics & Gynecology

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There is concern regarding the influence of hormonal contraceptives on bone mineral density (BMD), especially following the alert issued by the US FDA regarding the use of depot-medroxyprogesterone acetate (DMPA). That statement raised the concern, not only for health providers but also for users and potential users, that other combined contraceptives and progestin-only (p-only) contraceptives could have a deleterious effect on BMD. Overall, hormonal and nonhormonal contraceptives are known to have a high impact on the lives and health of women, as well as on public health. The benefits greatly surpass any risks, including the risk of any potential effect on BMD. Although convincing evidence is accumulating that DMPA may cause loss of BMD, most studies evaluating the effects of combined and other p-only contraceptives on BMD have failed to find a strong effect. Some have reported a beneficial effect. However, hormonal contraceptives were not designed to protect bone health and further studies are necessary.

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Effect of Norplant contraceptive on the bones of Nigerian women as assessed by quantitative ultrasound and serum markers of bone turnover

Cited by 5 publications

References 25 publications

Progestogen-only contraception and bone mineral density: a systematic review

Progestogen-only contraception and bone mineral density: a systematic review

The effects of hormonal contraceptives on bone turnover markers and bone health

Does the use of hormonal contraceptives affect bone mineral density?

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