Effect of Non‐Surgical Periodontal Treatment on Visfatin Concentrations in Serum and Gingival Crevicular Fluid of Patients With Chronic Periodontitis and Type 2 Diabetes Mellitus

Wu, Yun; Ling, Chen; Wei, Bin; Luo, Kai; Yan, Fuhua

doi:10.1902/jop.2015.140476

Cited by 32 publications

(35 citation statements)

References 36 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some adipokines (leptin) have an anti-inflammatory influence on tissue fortification whereas others (resistin and visfatin) have a pro-inflammatory influence. There are also adipokines (progranulin) that have both pro-inflammatory and anti-inflammatory characteristics (31,32). The importance of higher concentrations of resistin, leptin, IL-6 and TNF-α or reduced levels of adiponectin and visfatin in the pathogenesis of T2DM and periodontal disease is widely acknowledged and clearly understood (3,5,9,12,22).…”

Section: Discussionmentioning

confidence: 99%

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

et al. 2016

View full text Add to dashboard Cite

Abstract:The aims of the present study were to determine the levels of vaspin and omentin-1 in gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (T2DM), and to evaluate GCF vaspin and omentin-1 levels after non-surgical periodontal therapy. The study included 60 subjects: 15 systemically and periodontally healthy individuals, 15 periodontally healthy patients with T2DM, 15 systemically healthy patients with CP, and 15 patients with both CP and T2DM. GCF and clinical periodontal parameters were examined at the baseline and 6 weeks after periodontal therapy. Levels of vaspin, omentin-1 and tumor necrosis factor-alpha (TNF-α) were measured by ELISA, and their relative ratios were calculated. GCF vaspin and TNF-α levels were significantly higher in the CP groups than in the periodontally healthy groups (P < 0.008) and decreased after therapy in the former (P < 0.025). GCF omentin-1 levels were significantly lower in the CP groups than in the periodontally healthy groups (P < 0.008) and increased after therapy in the former (P < 0.05). Statistically significant positive correlations were found between the total amount of vaspin and TNF-α, glycated hemoglobin (HbA1c), clinical attachment level and gingival index, whereas the level of omentin-1 was negatively correlated with these parameters in all groups (P < 0.05). We found that non-surgical periodontal therapy influenced the GCF levels of both vaspin and omentin-1 in the CP groups. IntroductionChronic peridontitis (CP) is an infectious condition that degrades and deteriorates the vital periodontal tissues around the teeth (1). The deterioration of soft and hard tissues resulting from periodontitis is due to stimulation of the host immunoinflammatory reaction to pathogens in the mouth (2). The host response to these infectious pathogens leads to dispersal of inflammatory mediators, including the pro-inflammatory cytokines interleukin-1 (IL-1), IL-6, tumor necrosis factor alpha (TNF-α), and prostaglandins (PGE2), the latter exacerbating deterioration of the periodontium. The increased cytokine levels present in periodontitis are also likely to aggravate existing conditions, such as atherosclerosis, diabetes, and rheumatoid arthritis (3). A number of theories have been offered to explain the

show abstract

Section: Discussionmentioning

confidence: 99%

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A previous study showed that visfatin levels decreased 8 weeks after periodontal treatment (37). Wu et al (38) evaluated the role of visfatin in patients with T2DM and CP before and 3 and 6 months after non-surgical periodontal treatment. They reported that non-surgical periodontal treatment reduced visfatin and HbA1c levels in periodontitis patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

et al. 2016

View full text Add to dashboard Cite

The purpose of this study was to evaluate visfatin levels at different stages of periodontal disease and in healthy tissues. In addition, the effect of non-surgical periodontal therapy on visfatin levels in gingival crevicular fluid and serum was investigated. Forty-five patients were divided into three groups based on clinical and radiographical findings. Group 1 comprised periodontally healthy individuals (n = 15); group 2 comprised patients with gingivitis (n = 15); and group 3 was composed of patients with generalized chronic periodontitis (n = 15). Gingival crevicular fluid and serum samples were collected before treatment and at 1, 3, and 6 months after treatment. Visfatin levels were measured by enzymelinked immunosorbent assays. Gingival crevicular fluid and serum visfatin levels were higher in patients with chronic periodontitis than those with gingivitis or healthy controls (P < 0.016). In addition, visfatin levels were higher in the gingivitis group than in healthy controls (P < 0.016). Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels.

show abstract

“…Wu et al 42) reported that no significant decrease was observed in the HbA1c level in the experimental group relative to the control group at 3 months. However, a significant decrease was observed at 6 months (p=0.00) 42) .…”

Section: Search Resultsmentioning

confidence: 93%

“…Raman et al 40) , 32 patients; Wu et al 42) , 46 patients; and that by Mizuno et al 43) , 37 patients. Although these sample sizes were statistically calculated, they are close to the minimum number of patients required, and these studies note the small sample sizes as their limitation.…”

Section: Discussionmentioning

confidence: 94%

“…41) , and Wu et al 42) ; 4 months in a study by Gay et al A study by Engebretson et al 38) had a relatively larger sample size of 514 patients compared with other studies, but the results had missing standard deviations. Thus, all studies could not be included in the analysis because the results remained unclear, and this was considered a limitation of this study.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Effects of Periodontal Treatment on Glycated Hemoglobin A Levels in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials

Son

Lee

2018

J Dent Hyg Sci

View full text Add to dashboard Cite

This systematic review aimed to investigate the effects of periodontal treatment on glycated hemoglobin A (HbA1c) levels in patients with type 2 diabetes who develop periodontal disease. The search of the MEDLINE, Embase, CINAHL, and Cochrane Library databases was completed on April 8, 2018. The study design was based on randomized clinical trials. Scaling and root planing was performed for the test group, whereas no periodontal treatment or simple oral training was performed for the control group. The main outcome variable was the change in HbA1c levels. We used the Review Manager statistical analysis software for the quantitative analysis of selected documents. Meta-analysis was performed using the inverse variance estimation method of the fixed-effect model to estimate the effects of periodontal treatment on HbA1c levels in patients with type 2 diabetes. A total of 1,011 documents were searched using search strategies, and 10 documents were included in the meta-analysis. The meta-analysis of the selected literature showed that periodontal treatment significantly reduced the HbA1c levels in patients with type 2 diabetes who develop periodontal disease (mean difference, −0.34; 95% confidence interval, −0.43 to -0.26; p＜0.001). This study aimed to investigate the effects of periodontal treatment on HbA1c levels, which can be used as a basis for the increasing management of diabetic complications. To improve the quality of life and reduce the burden of medical expenses for patients with diabetes, periodontal disease management through nonsurgical periodontal treatment, such as scaling and root planing, is necessary.

show abstract

Effect of Non‐Surgical Periodontal Treatment on Visfatin Concentrations in Serum and Gingival Crevicular Fluid of Patients With Chronic Periodontitis and Type 2 Diabetes Mellitus

Cited by 32 publications

References 36 publications

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

Effects of Periodontal Treatment on Glycated Hemoglobin A Levels in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials

Contact Info

Product

Resources

About