Effect of Non-surgical Periodontal Therapy on Serum and Salivary Concentrations of Visfatin in Patients with Chronic Periodontitis

Abstract

Background and aims. Visfatin, mainly secreted by visceral adipose tissue, especially by macrophages, plays an important role in regulating the defense and immune functions, and functions as a growth factor, a cytokine, an enzyme and more importantly as a proinflammatory mediator. The aim of the present study was to evaluate the effect of non-surgical periodontal treatment on serum and salivary levels of visfatin in patients with generalized moderate-to-severe chronic periodontitis.Materials and methods. Eighteen patients with generalized moderate-to-severe chronic periodontitis were selected based on periodontal parameters of gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and radiographic parameters. Serum and salivary samples were collected at baseline and one month following non-surgical periodontal therapy (scaling and root planing ([SRP]). Visfatin levels were measured using an ELISA kit. Data were analyzed by SPSS 15, using paired t-test and Pearson's correlation coefficient.Results. Mean salivary and serum levels of visfatin significantly decreased after non-surgical periodontal treatment (P<0.05). Changes in salivary visfatin levels were more prominent.Conclusion. According to the findings of this study it seems that there is a direct relationship between periodontal tissue inflammation and disease activity with salivary and serum visfatin levels.

Porphyromonas gingivalis and Epstein‐Barr Virus Are Associated With Increased Levels of Visfatin in Gingival Crevicular Fluid

“…Then, Raghavendra et al 36 showed that increased GCF visfatin levels in periodontitis reached levels similar to those in healthy individuals after periodontal treatment. In additional studies, this adipokine in saliva was found to be a marker of inflammation in periodontal disease, and the levels in saliva decreased after periodontal treatment 25 , 37 . In this study, the level of visfatin in GCF in patients with periodontitis was higher compared with that of the healthy individuals, which is consistent with these other studies.…”

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

“…They reported that non-surgical periodontal treatment reduced visfatin and HbA1c levels in periodontitis patients with T2DM. The serum and salivary levels of visfatin were also shown to decrease significantly after non-surgical periodontal treatment (39). In the present study, a significant decrease in visfatin levels was observed 1 month after non-surgical periodontal treatment in gingivitis and CP individuals.…”

Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

“…In several studies, high levels of visfatin have been reported in saliva, GCF, and periodontal tissue in periodontitis 6,7,41‐43 . In contrast, visfatin GCF and saliva levels have been reported to decrease after NSPT 15–18 . In another study by the present authors’ research group, it was suggested that the microbiologic agents that colonize the subgingival region in periodontitis can increase visfatin expression 19 .…”

“…Its role in periodontal inflammation has been demonstrated in several recent studies. Increased levels in saliva and gingival crevicular fluid (GCF) were found to decrease after non‐surgical periodontal therapy (NSPT) 15–19 . Chemerin is another proinflammatory adipokine with a different mechanism 20 .…”