To the best of the authors' knowledge, the present study is the first one to show the correlation of periodontopathogens and GCF visfatin levels. P. gingivalis colonization of the periodontal pockets may increase visfatin secretion. Furthermore, the presence of EBV in the plaque may be another factor that causes an increase in visfatin levels.
Background
Several potential benefits have been attributed to the platelet‐rich fibrin (PRF), including enhanced tissue healing properties. In this study, we hypothesized that the application of PRF as an adjunct to conventional scaling and root planing (ScRp) would enhance the outcomes of non‐surgical periodontal therapy.
Methods
The present study was a split‐mouth randomized controlled clinical trial design in 24 deep periodontal pockets in 12 patients with periodontitis. The pockets were randomly assigned as test or control. The test group received PRF as an adjunct to ScRp, whereas the control group received ScRp only. We measured periodontal clinical parameters at baseline, 3, and 6 months after the treatments. To study the initial healing in response to treatment, transforming growth factor‐β (TGF‐β) and collagen‐1 (Col‐1) in gingival crevicular fluid (GCF) were measured using enzyme‐linked immunosorbent assay at baseline, third, seventh, and 14th days.
Results
The test group showed a significantly greater pocket reduction, higher clinical attachment gain, and less gingival recession than the control group at 3 and 6 months. The test Col‐1 levels (1.27 ± 1.05, 1.35 ± 0.76, 0.97 ± 0.53 ng/site) and TGF‐β levels (11.93 ± 2.68, 12.54 ± 3.66, 17.19 ± 11.66 pg/site) were higher than the control Col‐1 levels (0.76 ± 0.20, 0.84 ± 0.24, 0.57 ± 0.19 ng/site) and TGF‐β levels (6.34 ± 1.67, 6.35 ± 3.44, 7.51 ± 2.85 pg/site) at all measurement days respectively.
Conclusions
Non‐surgical application of the PRF as an adjunct to conventional ScRp may effectively improve the periodontal clinical parameters via increasing expression of the GCF TGF‐β and Col‐1 levels.
Is formocresol effective on periodontal pathogens in periodontal endodontic lesions ? ÖZET Periodontal endodontik lezyonlarda formokrezol kullanımı periodontopatogenlere karşı etkili mi dir ? Amaç: Bu çalışmanın amacı primer periodontal sekonder endodontik lezyonlarda formokrezol kullanarak/kullanmadan yapılan endodontik tedavinin periodontal cep florası üzerine etkilerinin değerlendirilmesidir. Materyal ve Metodlar: Çalışmaya klinik ve radyolojik olarak periodontal endodontik lezyonu bulunan 12 hasta dahil edilmiştir. Hastaların periodontal patolojik ceplerinden kök kanal tedavisi (KKT) öncesi, ikinci seans öncesi ve üçüncü seans öncesi, bir hafta aralıklarla olmak üzere gracey küretler yardımıyla plak örnekleri alındı. KKT sırasında ilk seansta pulpa odası boş bırakılırken ikinci seansta pulpa odasına formokrezol emdirilmiş pamuk pelet yerleştirildi. Alınan örneklerde Fusobacterium nucleatum, Campylobacter rectus, Tannerella Forsythia, Provetella intermedia, Porpyhromonas gingivalis, Aggregatibacter actinomicescomitans Polymerase Chain Reaction yöntemiyle değerlendirildi. Bulgular: Tedavi süresince elde edilen örneklerde mikroroganizmalar açısından hiçbir fark bulunmadı (p>0.05). Sonuç: KKT işlemleri ve formokrezol kullanımı kısa dönemde periodontal cep florasına etki etmemektedir.
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