Effect of long term administration of dietary β-glucan on immunity, growth and survival of Labeo rohita fingerlings

Misra, C.; Das, Basanta Kumar; Mukherjee, Subhas; Pattnaik, Phalguni

doi:10.1016/j.aquaculture.2005.12.009

Cited by 214 publications

(231 citation statements)

References 41 publications

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“…The activation of complement, either the classical or alternative pathway, leads to the production of several soluble components involved in chemiotaxis, opsonization, phagocytosis and pathogen destruction (Magnadóttir et al 2005). Inclusion of β-glucan into the diet of carps (Labeo rohita and Cyprinus carpio) also improved complement activity (Misra et al 2006) and heightened expression of complement genes in several tissues (Pionnier et al 2013). Furthermore, the activity of the alternative complement cascade might also be improved by adding Saccharomyces cerevisiae to the diet of Epinephelus coioides (Chiu et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, adaptation of fish to the tank environment might contribute to alter blood cells and even decrease the circulation of immune cells due to cortisol release (Gabriel et al 2011). In addition, at least one study indicated that Indian carps (Labeo rohita) had reduced total leukocytes counts after a two week feeding trial with β-glucan (500mg/Kg of feed) (Misra et al 2006). In fish fed with 0.1% β-glucan, the number of monocytes and thrombocytes were not altered at the end of the experiment and it would be tempting to attribute this effect to β-glucan.…”

Section: Discussionmentioning

confidence: 99%

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Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Domenico

Canova²,

Soveral³

et al. 2017

Pesq. Vet. Bras.

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RESUMO.-[Efeito imunomodulador da β-glucana usada como aditivo alimentar em jundiás (Rhamdia quelen).]O uso da β-glucana como suplemento alimentar foi avaliado em jundiás. A β-glucana foi adicionada à ração na proporção de 0.01%, e 0.1% e fornecida aos peixes por 21, para avaliar dados hematológicos e parâmetros do sistema imune natural, ou 42 dias, para avaliar ganho de peso e resistência ao desafio com Aeromonas hydrophila. A adição da β-glucana na dieta não afetou o ganho de peso e não induziu alterações hematológicas nem alterações nos níveis de aglutininas e mieloperoxidase sanguínea. No entanto, a atividade hemolítica natural do sistema do complemento foi significativamente maior nos peixes alimentados com β-glucana. Além disso, nos peixes alimentados com β-glucana e desafiados com A. hydrophila, o número de bactérias isoladas do sangue foi significativamente menor, e a sobrevivência ao desafio foi significativamente maior do que nos peixes que não receberam β-glucana. Consequentemente, concluímos que a β-glucana tem potencial imunomodulador quando adicionada à dieta, nas condições experimentais aqui indicadas, e contribui para aumentar imunidade natural e a resistência dos jundiás ao desafio com patógenos específicos. INTRODUCTIONThe occurrence of infectious diseases is one of the major causes of losses in modern aquaculture (Sitjà-Bobadilla The immunomodulatory effects of dietary β-glucan were evaluated in silver catfish. β-glucan was added to the diet (0.01%, and 0.1%) and fed to the fish for 21 days, to evaluate effects on blood and some innate immune parameter, or fed for 42 days, to evaluate growth rate and resistance to challenge with pathogenic Aeromonas hydrophila. We found that adding β-glucan to the diet had no effect on fish growth and no effect on blood cells, or serum bacterial agglutination and serum myeloperoxidase activity. However, fish that received β-glucan in the diet had the natural hemolytic activity of complement significantly higher compared to control fish. Furthermore, fish fed with β-glucan and challenged with A. hydrophila had fewer bacteria in blood and presented a significantly higher survival rate compared to control fish. Thus, we concluded that β-glucan might be explored as feed additive aiming to improve silver catfish innate immunity and resistance to specific pathogen.INDEX TERMS: Silver catfish, Rhamdia quelen, fish, immunostimulants, β-glucan, Aeromonas hydrophila.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Domenico

Canova²,

Soveral³

et al. 2017

Pesq. Vet. Bras.

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“…Immunostimulation is an important tool in aquaculture to increase resistance to pathogens [3] especially since substances, such as β-glucan, occur naturally in the environment and are thus less likely to raise concerns about residues in food fish and the environment [4]. Previous studies on β-glucan have highlighted a time and dose dependency of the effects [1,[33][34][35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

“…However for many substances used as immunostimulants, including LPS and β-glucan, effectiveness is dose dependent, such that high concentrations often lead to adverse effects, including immunosuppression [19,38,40,41]. As a result the resistance of the animals to pathogens is not enhanced or is even decreased at high concentrations, and hence it is important for both feed manufacturers and fish farmers that the dietary dose of the immunomodulating substance utilized does not induce such negative effects.…”

Section: Discussionmentioning

confidence: 99%

Time and concentration dependency of MacroGard® induced apoptosis

Miest

Hoole

2015

Fish & Shellfish Immunology

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In previous studies an effect of β-glucan on apoptosis in fish was noted and in this investigation we determine the time and concentration dependency of this effect. Primary cell cultures of pronephric carp cells were incubated for 6, 24, 48 h with various concentrations ranging from 0 -1000 μg/ml of MacroGard ® β-glucan. Apoptosis was monitored via acridine orange staining. Results indicate a clear effect of time and concentration on the induction of apoptosis in vitro, with only concentration ≥ 500 μg/ml causing significantly higher percentages of apoptotic cells. Apoptosis was detected after 6 h. This concentration dependent effect has to be considered when studying apoptosis in relation to immunostimulation.

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“…Além disso, é considerada como potente imunoestimulante para mamíferos e peixes. Para os últimos, a β-glicana pode ativar macrófagos, aumentando sua capacidade de matar patógenos, além de ter efeito protetor contra uma grande variedade de bactérias patogênicas como Aeromonas Hidrophila, Edwardsiella tarda e Vibrio salmonicida (MISRA et al, 2006). O efeito positivo da suplementação dessa fração na dieta de leitões foi relatado por Li et al (2006), onde a adição de 50 ppm de β-glicana na dieta levou a um aumento de 12,7% no ganho de peso, corroborando com esses resultados.…”

Section: Frações De Fibra Que Exercem Efeito Prebióticounclassified

Importância da fibra alimentar na nutrição de animais não ruminantes

et al. 2016

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For a long time the dietary fi ber represented the inert portion of food because of their low energy content. In addition, this fraction was also considered undesirable nutrients in monogastric diet, due mainly to the negative effects of their presence, as its dilutive effect of energy. However, these effects may be related to erroneous quantifi cation of that fraction. When correctly determined and added in suitable amounts, the effects of this nutrient bring several benefi ts to the animals. Dietary fi bers are formed by non-starch polysaccharides, among which we can highlight the cellulose, hemicellulose, pectins, gums, mucilages, β-glucans, among others. Fractions that has received much attention due to their prebiotic properties. The main prebiotic action occurs by activating the metabolism of a group of benefi cial bacteria in the gastrointestinal tract, promoting an increase in the production of short chain fatty acids and number of villi in ileum allowing increase in area absorptive intestinal and therefore improve animal performance.

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Effect of long term administration of dietary β-glucan on immunity, growth and survival of Labeo rohita fingerlings

Cited by 214 publications

References 41 publications

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Time and concentration dependency of MacroGard® induced apoptosis

Importância da fibra alimentar na nutrição de animais não ruminantes

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