Effect of local use of <scp>l</scp>-carnitine after myringotomy on myringosclerosis development in rats

Vuralkan, Erkan; Tokgöz, Serhat; Şimşek, Gökçe; Köybaşıoğlu, Fulya; Han, Ünsal; Çalışkan, Murat; Beşaltı, Ömer; Akın, İstemihan

doi:10.1017/s002221511300056x

Cited by 12 publications

(12 citation statements)

References 15 publications

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“…Therefore, MS may be prevented or reduced by administration of anti-inflammatory or antioxidant agents which can inhibit the harmful effects of oxygen derived free radicals. For this purpose, several free radical scavengers have been used to reduce the formation of MS after experimental myringotomy in previous reports [2,3,[7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model

Eğilmez

Kökten

Ekici

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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Section: Introductionmentioning

confidence: 99%

The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model

Eğilmez

Kökten

Ekici

et al. 2015

International Journal of Pediatric Otorhinolaryngology

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“…After the revelation of the role of oxygen free radicals in the pathogenesis of MS, thanks especially to the study of Mattson et al [21] , many studies showed that this damage, caused by oxygen free radicals, could be successfully reduced or prevented by using antioxidant, free radical connective substances and anti-inflammatory agents that have been reported in the literature. Of these, ascorbic acid, vitamin E, selenium, L-carnitine, N-acetylcysteine , caffeic acid, ginkgo biloba, pomegranate, N-nitro L-arginine, steroids, and melatonin can be considered [6,17,[21][22][23][24][25][26][27][28][29] .…”

Section: Discussionmentioning

confidence: 99%

“…Many researchers evaluating the effectiveness of antioxidant and anti-inflammatory agents in MS have used tympanic membrane thickness as a parameter for histopathological evaluation and claimed that there was a positive correlation between TM thickness and the severity of myringosclerosis [25][26][27][28][29] . Kazikdas et al [29] showed the preventive effect of melatonin on MS, which is an antioxidant that is saved from lipid peroxidation and reduces proinflammatory cytokine levels.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

Tatar¹,

Yörük²,

Ünal³

et al. 2015

Int Adv Otol

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OBJECTIVE: Alpha-lipoic acid (ALA) is an anti-inflammatory and antioxidant agent. In this study, the effects of ALA on the development of myringosclerosis in myringotomized rats were investigated. MATERIALS and METHODS:The rats were studied in five groups: each group included 6 rats (for a total of 30 rats). After a myringotomy was performed, the groups were administered a 25-mg/kg/day and 50-mg/kg/day dose of ALA for 15 days. The eardrums of the rats were examined histopathologically. We made the histopathological assessment from 0 to 3 on a 4-point scale by scoring the degree of the histopathological changes. In addition, superoxide dismutase, malondialdehyde, and glutathione peroxidase levels were measured in blood samples taken from the rats. RESULTS:In histopathological examinations, a high dose (50 mg/kg/day) of the ALA-applied group had histopathological results similar to those of the healthy group. In this group, we detected minimal collagen deposition, slight thickness in the lamina propria, and minimal epithelial disruption. In biochemical examinations, the maximum values of superoxide dismutase and glutathione peroxidase were observed in the group that received 50 mg/kg/day of ALA. CONCLUSION:In this study, the effect of ALA on myringosclerosis development was observed when a dose of 50 mg/kg/day was administered, and a recovery that showed a nearly intact tympanic membrane occurred at the end of 15 days of use. If an antioxidant were to be added to the treatment protocol of tympanic membrane defects, ALA may be a good candidate.

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“…The study was approved by the Ethics Committee of Ankara University Experimental Animal Research Laboratory (2013-8, File No. 2013.…”

Section: Methodsmentioning

confidence: 99%

The Impact of Systemic and Local Administration of Ascorbic Acid on Traumatic Perforation of Tympanic Membrane and Myringosclerosis

Güneş

Mutlu

Akın³

et al. 2015

Int Adv Otol

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OBJECTIVE:In the present study, tympanic membranes (TM) harvested from myringotomized rats were analyzed histopathologically to compare the systemic and local effects of ascorbic acid on the development of myringosclerosis. MATERIALS and METHODS:Forty male Wistar-Albino rats weighing between 350-400 g were included in this study. Under otomicroscopic examination, a standard 2-mm myringotomy incision was made on the posteroinferior quadrant of the TM of both ears. Rats were randomized into five groups as control, topical ascorbic acid 50 mg/kg, systemic ascorbic acid 50, 100, and 200 mg/kg groups, each group containing eight rats. On the 15th day of the study, the rats were decapitated, and bullas of the rats were extracted. Sections were stained with hematoxylin-eosin and examined through light microscopy. Inflammation, distribution width of plaques, edema, and neovascularization were observed on the lamina propria. Thickness of the TM was evaluated under the microscope and scored semiquantitatively. RESULTS:When intergroup comparisons of parameters related to total TM thickness were performed, differences between the control group and topical AA (ascorbic acid) or systemic treatment groups were found to be statistically significant (p<0.005). A statistically significant difference was detected among control, topical and systemic 200 mg/kg ascorbic acid groups for the edematous lamina propria (p=0.003 and p<0.05, respectively). CONCLUSION:For the total TM thickness, systemic and topical ascorbic acid use was effective when compared with the control group. It has been concluded that systemic use of higher doses of (200 mg/kg) ascorbic acid is beneficial in the resolution of the edematous lamina propria.

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Effect of local use of l-carnitine after myringotomy on myringosclerosis development in rats

Cited by 12 publications

References 15 publications

The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model

The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model

The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

The Impact of Systemic and Local Administration of Ascorbic Acid on Traumatic Perforation of Tympanic Membrane and Myringosclerosis

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