The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model

Does Hypericum Perforatum Have Inflammatory or Anti-Inflammatory Effects?

“…They also indicated that their study on the potential curative role of HP in the healing of TM perforation was the first in the literature [3] . However, in the study by Eğilmez et al [4] published in July 2015, the effect of HP on myringosclerosis and the healing of TM perforations in all animals was evaluated, and it was also found that the rate of myringosclerosis in the lamina proprias of TMs is lower because of the high anti-inflammatory activity of HP. In the study by Eğilmez et al [4] a group of animals fed with oral gavage was obtained because of the high systemic absorption of the oily solution of HP from the gastrointestinal tract.…”

“…However, in the study by Eğilmez et al [4] published in July 2015, the effect of HP on myringosclerosis and the healing of TM perforations in all animals was evaluated, and it was also found that the rate of myringosclerosis in the lamina proprias of TMs is lower because of the high anti-inflammatory activity of HP. In the study by Eğilmez et al [4] a group of animals fed with oral gavage was obtained because of the high systemic absorption of the oily solution of HP from the gastrointestinal tract. It was shown that the systemic effect of the oily solution of HP is similar to that of its topical form.…”

The effect of Nigella sativa oil on prevention of myringosclerosis in a Guinea pig model

“…A wide variety of free radical scavengers like L-carnitine, ascorbic acid, zinc aspartate, N-acetylcysteine, selenium, Ginkgo biloba, vitamin C and E, Caffeic acid phenyl ester (CAPE), N-nitro L-arginine metyl ester ( L -NAME), melatonin, Hypericum perforatum, and enoxaparin sodium have been proposed to use for preventing the development of MS in TM in several studies[1,2,[6][7][8][9][10]11,20,21,[23][24][25][26][27]. Free radical scavengers process via suppressing the generation of active oxygen species and free radicals, scavenging them, and repairing damage.…”

Letter to the Editor about ‘The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model’

“…[1] Unfortunately some topical drugs and oral drugs have ototoxic effects like aminoglycosides and some antineoplastic agents. [3][4][5] There is no information about ototoxicity of Hypericium perforatum in this article.…”

“…writing in reference to a thought provoking study titled 'The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model'[1] published in your esteemed journal. The study has been well planned and we would like to appreciate the effort made by the authors to shed light on this topic.…”