The effect of Nigella sativa oil on prevention of myringosclerosis in a Guinea pig model

Kökten, Numan; Eğilmez, Oğuz Kadir; Ekici, A. Işın Doğan; Kalcıoğlu, M. Tayyar; Tekın, Muhammet; Yeşilada, Erdem

doi:10.1016/j.ijporl.2016.06.050

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Although the exact etiopathology of MS is unknown, hyperoxic conditions and increased oxygen-derived free radicals caused by trauma have been attributed to play an important role ( 7 , 8 ). Setting out from this point of view, various anti-inflammatory and antioxidant agents have been used in experimental studies to reduce and prevent the effects of these free radicals ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model

Eğilmez¹,

Güven²,

Elden³

et al. 2021

TAO

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Objective: The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS). Methods: Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol. Results: In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p<0.05). Fibrosis and inflammation regarding the lamina propria (LP) of the eardrums of the topical and oral eugenol groups were significantly less than those of the control and saline groups (p<0.001). In microscopic evaluation, TMs were found to be thicker in the control and saline groups (p<0.001). Conclusion: Our study showed that the application of topical and oral forms of eugenol reduced fibrosis and prevented the advancement of MS in the LP of the TMs in the short-term. More studies with different extracts are needed to investigate the efficacy of phytotherapeutic agents for preventing MS development following myringotomy.

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