Effect of laser functionalization of titanium on bioactivity and biological response

Kuczyńska-Zemła, Donata; Kijeńska‐Gawrońska, Ewa; Pisarek, Marcin; Borowicz, P.; Święszkowski, Wojciech; Garbacz, Halina

doi:10.1016/j.apsusc.2020.146492

Cited by 9 publications

(3 citation statements)

References 55 publications

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“…In the case of processes carried out for continuous laser operation, in most cases, after 50 days from the functionalization process, the surface becomes hydrophobic, while in the case of treatments in the pulsed laser mode, the droplets spread out. This result is in contradiction with literature reports, in which for the functionalization processes of titanium alloys, using a pulsed laser, hydrophobic surfaces were obtained almost immediately [ 24 , 25 ].…”

Section: Resultscontrasting

confidence: 99%

Changes in the Laser-Processed Ti6Al4V Titanium Alloy Surface Observed by Using Raman Spectroscopy

et al. 2022

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This works reports on the effects of treating the surface of Ti6Al4V titanium alloy samples with a laser with a wavelength of 1064 nm, operating in a pulsed and continuous mode. The obtained surfaces with different roughness, complexity and wettability were examined by Raman spectroscopy in order to recognize the presence of titanium oxides on the functionalized surface. The layer of titanium oxides on the surface with the identified rutile phase obtained by laser treatment in the continuous wave mode is a reason for a hydrophobic surface that appeared 50 days after the treatment process. In the case of the surface obtained by the pulsed laser process, only local points at which the Raman bands attributed to the metastable phases anatase and brookite of TiO2 can be identified. In this treatment process, complete surface hydrophilicity was observed during 29 days after the functionalization process (maximal contact angle observed during this time was 68.4 deg). For some functionalization processes of different parameters, the contact angle remained immeasurable until 119 days after the functionalization process. In summary, Raman spectroscopy identifies surface changes of Ti6Al4V after laser processing.

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Section: Resultscontrasting

confidence: 99%

Changes in the Laser-Processed Ti6Al4V Titanium Alloy Surface Observed by Using Raman Spectroscopy

et al. 2022

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“…The laser treatment of the surfaces significantly increased the hydroxyapatite precipitation, which was due to the increasing surface roughness contributing to the enhanced osseointegration. Kuczy ńska-Zemła et al [41] used the direct laser interference lithography on the acid-etched surfaces of the commercially pure (cp) titanium grade 2 to form uniform Ca-P coatings on them. They found that osteoblasts preferred to grow along these obtained patterns.…”

Section: Introductionmentioning

confidence: 99%

Laser Surface Modification of Powder Metallurgy-Processed Ti-Graphite Composite Which Can Enhance Cells’ Osteo-Differentiation

et al. 2021

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The paper examines the surface functionalization of a new type of Ti-graphite composite, a dental biomaterial prepared by vacuum low-temperature extrusion of hydrogenated-dehydrogenated titanium powder mixed with graphite flakes. Two experimental surfaces were prepared by laser micromachining applying different levels of incident energy of the fiber nanosecond laser working at 1064 nm wavelength. The surface integrity of the machined surfaces was evaluated, including surface roughness parameters measurement by contact profilometry and confocal laser scanning microscopy. The chemical and phase composition were comprehensively evaluated by scanning electron microscopy, energy-dispersive X-ray spectroscopy and X-ray diffraction analyses. Finally, the in vitro tests using human mesenchymal stem cells were conducted to compare the influence of the laser processing parameters used on the cell’s cultivation and osteo-differentiation. The bioactivity results confirmed that the surface profile with positive kurtosis, platykurtic distribution curve and higher value of peaks spacing exhibited better bioactivity compared to the surface profile with negative kurtosis coefficient, leptokurtic distribution curve and lower peaks spacing.

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“…To this end, it has been speculated that engineered surfaces with hierarchical elements in the micro-and nanometer range possibly enhance the biomaterial activity via controlling cell proliferation and differentiation [14]. Providing excellent control over process parameters, laser-induced surface structuring on titanium alloys utilizing short and ultra-short pulsed (USP) lasers has been explored [15,16,17,18]. A commercially available surface generated by laser structuring revealed a high potential by a micro-channel arrangement combined with nanostructures in preclinical studies [19,20].…”

Section: Introductionmentioning

confidence: 99%

Rationally designed ultra-short pulsed laser patterning of zirconia-based ceramics tailored for the bone-implant interface

Ackerl¹,

Bork²,

Hauert³

et al. 2020

Preprint

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Ceramic composite materials are increasingly used in dental restoration procedures, but current ceramic surface designs do not yet achieve the osseointegration potential of state-of-the-art titanium implants. Rapid bone tissue integration of an implant is greatly dependent on its surface characteristics, but the material properties of ceramic composite materials interfere with classical surface modification techniques. Here, ultra-short pulsed laser machining, which offers a defined energy input mitigating a heat-affected zone, is explored for surface modification of ceramic composites. Inspired by surface textures of clinically relevant titanium implants, dual roughness surfaces are laser patterned. Raman mapping reveals a negligible effect of ultra-short pulsed laser ablation on material properties, but a laser-induced change in the wetting state is revealed by static contact angle measurements. Laser patterning of surfaces also influences blood coagulation, but not the attachment and spreading of osteoblastic cells. The presented laser machining approach thus allows the introduction of a rational surface design on ceramic composites, holding great promise for the manufacturing of ceramic implants.

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Effect of laser functionalization of titanium on bioactivity and biological response

Cited by 9 publications

References 55 publications

Changes in the Laser-Processed Ti6Al4V Titanium Alloy Surface Observed by Using Raman Spectroscopy

Changes in the Laser-Processed Ti6Al4V Titanium Alloy Surface Observed by Using Raman Spectroscopy

Laser Surface Modification of Powder Metallurgy-Processed Ti-Graphite Composite Which Can Enhance Cells’ Osteo-Differentiation

Rationally designed ultra-short pulsed laser patterning of zirconia-based ceramics tailored for the bone-implant interface

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