Rationally designed ultra-short pulsed laser patterning of zirconia-based ceramics tailored for the bone-implant interface

Ackerl, Norbert; Bork, Alexander H.; Hauert, Roland; Müller, Eike Hermann; Rottmar, Markus

doi:10.31224/osf.io/x69nu

Cited by 2 publications

(2 citation statements)

References 58 publications

(67 reference statements)

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“…[ 28 ] Similar behavior has previously been observed when laser‐texturing the surfaces of zirconia. [ 29 ] Other studies have shown that hydrophilic surfaces can be obtained using laser‐texturing by generating smoother surface features, with roughness values < 0.5 µm. [ 10 ] The modified WCA was expected to influence biological interactions with the surface, in particular the interaction with blood, which was previously shown to be enhanced on hydrophilic surfaces.…”

Section: Resultsmentioning

confidence: 99%

Femtosecond Laser‐Texturing the Surface of Ti‐Based Implants to Improve Their Osseointegration Capacity

Lackington

Schweizer

Khokhlova

et al. 2022

Adv Materials Inter

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Ideally, dental implants should achieve rapid and maintain long-term mechanical stability, which is determined primarily by their integration into the underlying supporting bone. [3] This osseointegration capacity can be markedly improved through modifications of key surface properties, including roughness, wettability, oxide layer thickness, and surface chemistry. [4][5][6] Currently, anodization, sandblasting and acid-etching are widely used, individually or in combination, to modify the surface properties of dental implants. However, not only are these methods inherently limited by their stochastic nature but they can also introduce surface contaminants, which require additional post-process cleaning steps that increase overall fabrication time and cost. [7] Laser-texturing has emerged as a promising alternative for the treatment of Ti implant surfaces, offering several advantages, including increased control, precision and reproducibility, while reducing processing time and costs. [8,9] Recently, laser-texturing has shown the capacity to direct osteoblast attachment [10] and to improve the osseointegration potential of Ti implant surfaces in comparison to polished surfaces, with the caveat that their performance in comparison to rougher, more clinically relevant surfaces, is still unknown. [11] Lasertexturing offers the capacity to easily generate a wide range of micro-and nano-scale topographical features and patterns. [12] In particular, due to its short pulse duration, femtosecond (fs)In modern oral maxillofacial surgery, long-term implant stability is intrinsically linked to the quality of osseointegration. While the osseointegration capacity of implants can be improved by modifying their surface properties, commonly used techniques, including sandblasting and acid etching, are stochastic processes offering virtually zero capacity to control the uniformity and reproducibility of micro-and nano-scale surface features. In this study, titanium-aluminiumvanadium (TiAlV) implant surfaces are modified using femtosecond (fs) lasertexturing, and its influence on physicochemical properties, on blood-implant interactions, and on the osseointegration potential is investigated in vitro. Lasertexturing enables the production of designer surfaces with micro-scale features defined in size and arrangement. While state of the art TiAlV surfaces prepared by sandblasting with biphasic calcium phosphate (BCP) show significant grain refinement at the near surface, fs laser-texturing preserves the grain size and enhances the microstrain and oxide layer thickness but also leads to 15% lower bulk fatigue in comparison to BCP treatment. Blood coagulation is similar on laser-textured and BCP surfaces, as is mineralization by human bone progenitor cells, albeit with a decreasing trend for laser-textured surfaces. Laser-texturing thus presents as a promising approach to create highly reproducible designer surfaces with biological performance comparable to state-of-the-art implants.

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Section: Resultsmentioning

confidence: 99%

Femtosecond Laser‐Texturing the Surface of Ti‐Based Implants to Improve Their Osseointegration Capacity

Lackington

Schweizer

Khokhlova

et al. 2022

Adv Materials Inter

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“…But the ceramic implants failed to perform clinically due to difficulty in threading, limited osseointegration, greater elastic modulus compared to titanium, and associated stress shielding. Although bioactivity and bone‐bonding efficacy of zirconia could be improved with various surface modifications, 5–8 modulus could not be altered as it is an inherent material property of metal oxides and requires innovations in structural and designing aspects for its modulation.…”

Section: Introductionmentioning

confidence: 99%

A novel strategy for fabricating zirconia implants with a trabecular biomimetic porous surface

Seesala

Dhara

2022

J Am Ceram Soc.

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For successful osseointegration of load‐bearing implants, an improved bone–implant contact area through a trabecular porous surface resulting in minimized stress shielding effect is highly desirable. We propose a novel strategy of green net shaping a ceramic dough, combined with a reticular foam replica method and gradient coating, to fabricate biomimetic porosity in a customizable ceramic dental implant for the first time. About 85 vol% porosity and 300–600‐μm pore size were evident in microCT and electron microscopy of the sintered samples, suitable for bone ingrowth. Excellent integrity at the interface along with homogeneous distribution of secondary alumina phase in zirconia matrix was achieved, despite the difference in the green state powder loading between the dough and the slurry.

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Rationally designed ultra-short pulsed laser patterning of zirconia-based ceramics tailored for the bone-implant interface

Cited by 2 publications

References 58 publications

Femtosecond Laser‐Texturing the Surface of Ti‐Based Implants to Improve Their Osseointegration Capacity

Femtosecond Laser‐Texturing the Surface of Ti‐Based Implants to Improve Their Osseointegration Capacity

A novel strategy for fabricating zirconia implants with a trabecular biomimetic porous surface

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