EFFECT OF KARAMUNTING LEAF EXTRACT (Melastoma malabathricum L.)  ON GLUCOSYLTRANSFERASE ENZYME OF Streptococcus mutans

Fajar, Ferdy Juliannor; Putri, Deby Kania Tri; Sukmana, Bayu Indra

doi:10.20527/dentino.v5i2.8946

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…The cytoplasmic membrane becomes damaged and semipermeable, causing leakage of cell components so that the bacterial cell dies. 17 The conclusion of this study is that ramania leaf extract (Bouea macrophylla griff) has antibacterial activity against Actinomyces spp. bacteria, so it has the potential to be used as an alternative material to support root canal irrigation.…”

Section: Discussionmentioning

confidence: 91%

“…This causes damage to the lipid structure of the DNA of the bacterial cell nucleus, resulting in inhibition of the development or growth of bacteria, and cell death. 7,17 Steroid compounds in ramania leaf extract function as antibacterials, namely by binding to cell phospholipid membranes that have permeable properties to lipophilic compounds, causing the membrane strength to decrease and causing damage to the cytoplasmic membrane of bacterial cells. 15,18 Similar to steroids, chlorhexidine gluconate 2% also has the ability to damage the cytoplasm of bacterial cells, namely by the interaction between the positive charge of the chlorhexidine molecules against the negatively charged bacterial cell wall, which then causes penetration into the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

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ANTIBACTERIAL ACTIVITY OF RAMANIA LEAF EXTRACT (Bouea Macrophylla Griff) AGAINST THE GROWTH Actinomyces spp

Hayati¹,

Erlita²,

Purwaningayu³

2023

Dentino

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Background: One of the causes of tooth nerve death or pulp necrosis is microorganisms, namely is Actinomyces spp. Ramania leaf extract (Bouea Macrophylla Griff) contains secondary metabolites, namely triterpenoids, alkaloids, saponins, tannins, flavonoids, steroids, and phenolics which function to inhibit the growth of Actinomyces spp. Purpose: This study aims to analyze the antibacterial activity of ramania leaf extract (Bouea Macrophylla Griff) at concentrations of 6,25%, 12,5%, 25%, 50%, and 100% against the growth Actinomyces spp. Methods: This research is a pure experimental (true experimental), with Posttest Only with Control Group Design. Antibacterial activity test used a paper disc diffusion with seven treatments, namely ramania leaf extract (Bouea Macrophylla Griff) with a concentration of 6,25%, 12,5%, 25%, 50%, and 100%, Chlorhexidine gluconate 2% as a positive control and Aquades as a negative control of Actinomyces spp were repeated 5 times. Measuring the diameter of the clear zone formed on Mueller Hinton Agar (MHA) media using a caliper. Results: Based on the results of the Mann Whitney test, there was 1 pair of groups that did not differ significantly in inhibiting Actinomyces spp bacteria, namely the 25% concentration group with a positive control of 2% Chlorhexidine gluconate, while the other groups had significant differences from each other. Conclusion: There is antibacterial activity in ramania leaf extract (Bouea Macrophylla Griff) against Actinomyces spp. Keywords: Actinomyces spp, Antibacterial Activities, Chlorhexidine gluconate 2%, Ramania Leaf Extract.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

ANTIBACTERIAL ACTIVITY OF RAMANIA LEAF EXTRACT (Bouea Macrophylla Griff) AGAINST THE GROWTH Actinomyces spp

Hayati¹,

Erlita²,

Purwaningayu³

2023

Dentino

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“…Berdasarkan hasil penelitian yang diperoleh dapat diketahui bahwa ekstrak daun karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) dapat digunakan sebagai antibakteri alami pengganti antibiotik untuk menyebuhkan penyakit karies gigi (29).…”

Section: Rendemenunclassified

Uji Aktivitas Antibakteri Ekstrak Daun Karamuntin (Rhodomyrtus tomentosa (Aiton) Hassk.) terhadap Bakteri Streptococcus mutans

Ramadhanty

Lestari

Nashihah

2023

JFI

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Abstrak: Indonesia memiliki banyak tanaman obat-obatan yang bisa digunakan untuk mengobati berbagai penyakit. Salah satu tumbuhan yang digunakan sebagai obat adalah daun karamunting (Rhodomyrtus tomentosa (Aiton)Hassk.). Secara tradisional daun Karamuting digunakan di masyarakat untuk mengobati karies gigi, mengobati luka dan kudis. Penelitian ini bertujuan untuk mengetahui pengaruh efek antibakteri ekstrak etanol daun karamunting terhadap bakteri Streptococcus mutans dengan menggunakan metode sumuran. Penelitian ini menggunakan penelitian eksperimental laboratorium. Sampel penelitian adalah ekstrak etanol daun karamunting. Ekstrak diuji aktivitas antibakteri terhadap Streptococcus mutans menggunakan metode difusi sumuran dengan konsentrasi 6,25%; 12,5%; 25%; 50% b/v. Hasil penelitian menunjukkan ekstrak Etanol daun karamunting mempunyai aktivitas antibakteri terhadap Streptococcus mutans pada konsentrasi 6,25%; 12,5%; 25%; 50% b/v masing-masing dengan diameter zona hambat sebesar 17,7±0,0577, 22,6±0,2516, 25,3±0,1527, and 28,3±0,0577. Ekstrak etanol daun karamunting mempunyai daya antibakteri terhadap Streptococcus mutans yang terbesar terdapat pada konsentrasi 50% dengan diameter 28,3 mm.

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“…14,15 Based on the side effects of chlorhexidine above, a new method is needed to prevent periodontitis with fewer side effects, namely using herbal plants. 16 The use of plants as medicine has long been known, one of the plants that has antibacterial power because of it's biologically active content, namely tamarind leaf (Tamarindus indica L.). [17][18][19] Previous research also reported that ethanol extract of tamarind leaf was proven to have an antibacterial effect against several types of bacteria.…”

Section: Introductionmentioning

confidence: 99%

EFFECTIVENESS OF TAMARIND LEAF (Tamarindus indica L.) ETHANOL EXTRACT ANTIBACTERIAL AGAINST Porphyromonas gingivalis

Baiin¹,

Mandalas²,

Sugiaman³

2023

Dentino

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Background: One of the initial measures to prevent chronic periodontitis is the use of mouthwash. Chlorhexidine is an antibacterial agent that can be used as a mouthwash. Chlorhexidine has side effects so that a new method is needed to prevent periodontitis with fewer side effects, namely by using plants as a medicine, one of the plants containing active compounds with antibacterial effects. The ethanol extract of tamarind leaf is proven to contain active compounds of flavonoids, tannins, alkaloids, and saponins. Purpose: The aim of the study was to analyze the antibacterial effect of ethanol extract of tamarind leaf (Tamarindus indica L.) leaf against Porphyromonas gingivalis bacteria. Material and methods: The research is an experimental laboratory type using the disc diffusion method (Kirby-Bauer), namely the paper disc diffusion method with the test material of ethanol extract of tamarind leaf (Tamarindus indica L.) in various concentrations, namely: 3.125%, 6.25%, 12.5 %, 25%, 50%, and 100%. Results: Based on the results of the research on the antibacterial effect of the ethanolic extract of tamarind leaf with concentrations of 3.125%, 6.25%, and 12.5% with an average diameter of 0.00 mm of inhibition zone. At concentrations of 25%, 50%, and 100%, they fall into the medium criteria group, because they have an average inhibition zone diameter of 5.21 mm, 7.45, and 9.16 mm, so that the concentration of 100% is closest to the average the mean diameter of the positive control group or chlorhexidine. Conclusion: It can be concluded that the ethanol extract of tamarind leaf (Tamarindus indica L.) has an antibacterial effect that can inhibit the growth of Porphyromonas gingivalis bacteria at a concentration of 100% with an average inhibition zone diameter of 9.16 mm. Keywords: Antibacterial, Porphyromonas gingivalis, Tamarind leaf

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EFFECT OF KARAMUNTING LEAF EXTRACT (Melastoma malabathricum L.) ON GLUCOSYLTRANSFERASE ENZYME OF Streptococcus mutans

Cited by 3 publications

References 8 publications

ANTIBACTERIAL ACTIVITY OF RAMANIA LEAF EXTRACT (Bouea Macrophylla Griff) AGAINST THE GROWTH Actinomyces spp

ANTIBACTERIAL ACTIVITY OF RAMANIA LEAF EXTRACT (Bouea Macrophylla Griff) AGAINST THE GROWTH Actinomyces spp

Uji Aktivitas Antibakteri Ekstrak Daun Karamuntin (Rhodomyrtus tomentosa (Aiton) Hassk.) terhadap Bakteri Streptococcus mutans

EFFECTIVENESS OF TAMARIND LEAF (Tamarindus indica L.) ETHANOL EXTRACT ANTIBACTERIAL AGAINST Porphyromonas gingivalis

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