Effect of isotretinoin treatment on the inflammatory markers in patients with acne vulgaris: can monocyte/HDL be a new indicator for inflammatory activity of isotretinoin treatment?

Kutlu, Ömer

doi:10.1080/15569527.2019.1701485

Cited by 17 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have shown that MHR could predict various inflammatory diseases such as metabolic syndrome, diabetes mellitus, CVD, and ISO usage 8,9,22 . Similarly, we have found a significant increase in MHR values in the 3rd month of ISO treatment.…”

Section: Discussionsupporting

confidence: 82%

“…Monocyte‐to‐high‐density lipoprotein ratio (MHR) is a recently defined inflammatory biomarker associated with metabolic syndrome and atherosclerosis 5 . Separate studies have reported an increase in MHR and carotid intima‐media thickness (CIMT) in acne patients after ISO treatment 7‐9 . Although ISO is known to predispose to hyperuricemia, we do not have enough clear information in the literature about the mechanism of triggering the increase in serum uric acid (SUA) level 10 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increases in uric acid and monocyte‐high‐density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin

Metin

Turan

2021

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Purpose We aimed to reveal the relationship of serum uric acid (SUA) with monocyte‐high‐density lipoprotein ratio (MHR) and other inflammatory markers in acne patients before and after isotretinoin treatment. In this way, we can try to shed light on the relationship between isotretinoin treatment and atherosclerosis. Methods Two hundred twenty‐four acne patients who administered isotretinoin (0.5‐1 mg/kg/day) were enrolled in the study. In the pretreatment phase and 3 months after treatment, MHR, SUA, mean platelet volume, neutrophil‐lymphocyte ratio (NLR), platelet‐lymphocyte ratio, monocyte‐lymphocyte ratio, serum triglyceride, total cholesterol, high‐density lipoprotein (HDL), and low‐density lipoprotein (LDL) levels of the patients were analyzed. Results Compared to the pretreatment phase, three months after treatment, there was a statistically decrease in neutrophil count and an increase in lymphocyte count (p: 0.002, p: 0.011, respectively). Accordingly, there was a statistically significant decrease in NLR (p: 0.001). It was noteworthy that MHR and SUA levels increased significantly (p: 0.042, p: 0.010, respectively) and there was a positive correlation between SUA level and MHR (r: 0.212, p: 0.012). Serum total cholesterol, LDL, and triglyceride levels increased and HDL levels decreased significantly after treatment (p: 0.001). Conclusion This study contributes to the comprehension of the relationship between isotretinoin treatment and atherosclerosis, which has been frequently reported in the literature. It was thought that the isotretinoin‐induced SUA increase might be related to dyslipidemia. Isotretinoin may initiate the atherosclerotic process in vascular endothelial and smooth muscles, with SUA increase and HDL decrease. An increase in MHR is also an inflammatory marker indicating this process.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Increases in uric acid and monocyte‐high‐density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin

Metin

Turan

2021

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…It has been reported that although other inflammatory parameters decreased with isotretinoin treatment, there was an increase in MHR ratio and that this increase could be an indicator of inflammation‐induced atherosclerosis risk. In this context, it is thought that the anti‐inflammatory effect of isotretinoin may be related to the pilosebaceous unit, while the inflammatory effect may be related to the endovascular system 27 . MHR was checked in addition to some inflammatory parameters in lichen planus patients and MHR was reported to be high in patients with lichen planus when compared with the control group 28 …”

Section: Discussionmentioning

confidence: 99%

“…In this context, it is thought that the anti-inflammatory effect of isotretinoin may be related to the pilosebaceous unit, while the inflammatory effect may be related to the endovascular system. 27 MHR was checked in addition to some inflammatory parameters in lichen planus patients and MHR was reported to be high in patients…”

Section: Ta B L E 1 Distribution Of Patient and Control Groups By Gendermentioning

confidence: 99%

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

2020

View full text Add to dashboard Cite

Acne vulgaris is a common inflammatory skin disease that affects the pilosebaceous unit. 1 Acne vulgaris affects 9.4% of the world population. It is most common among young people. It is more common among men; however, its prevalence increases with age in women. In male patients, the probability of severe acne is higher when compared with female patients. 2 Increased sebum production, hyperkeratosis in follicular infundibulum, inflammation and Propionibacterium acne (P acne) are among aetiological factors. Acne vulgaris lesions are first seen on the face and thus can affect patients' quality of life negatively. It has been claimed that acne can cause psychological diseases such as anxiety, low self-worth and depression among adolescents and adults. 1 Although its definite pathogenesis is not clear, immune response and inflammatory lesions caused by the P acne infection are considered as important factors. 3,4 Complete blood count is an analytical test with low cost and it is performed with automatic counting devices and it is used routinely. Complete blood count (CBC) parameters are used as diagnosis biomarkers for many diseases related with inflammatory processes.

show abstract

“…CBC parameters have been studied in previous studies (14)(15)(16)(17)(18). Especially calculated parameters such as NLR and PLR may be good predictors to evaluate the efficacy of systemic treatment.…”

Section: Discussionmentioning

confidence: 99%

Akne Vulgaris Hastalarında Tedavinin Hematolojik Parametreler Üzerine Etkisi

Saruhan

Alataş

2021

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

View full text Add to dashboard Cite

Akne vulgaris pilosebase ünitenin multifaktöriyel inflamatuvar hastalığıdır. Akne vulgaris gelişiminde çeşitli immünolojik ve inflamatuar faktörler farklı patofizyolojik mekanizmalarla sebum üretimini artırarak rol oynamaktadır. Bu çalışmanın amacı, akne vulgaris tedavi öncesi ve sonrası hemogram parametrelerinde meydana gelen değişiklikleri ortaya koymak ve bu parametrelerin tedavinin değerlendirilmesinde etkinliğini araştırmaktır. Çalışmaya 162 hasta (109 kadın, 67.3%; 53 erkek, 32.7%) dahil edildi. Çalışma sonucunda NEU, MPV, P-LCR ve PDW düzeylerinin tedavi sonrasında anlamlı derecede azaldığı saptandı (p<0.001). NLR ve PLR değerlerinde de tedavi sonrası anlamlı bir düşüş görüldü (p<0.001). LYM ve PLT sayısının ise tedavi sonrası arttığı görüldü (p<0.001). Akne vulgarisli hastalarda sistemik izotretinoin tedavisini değerlendirmede NLR, PLR ve P-LCR gibi hemogram parametreleri etkin şekilde kullanılabilir.Acne vulgaris is a multifactorial disease of the pilosebaceous unit. Various immunological and inflammatory factors play a role with different pathophysiological mechanisms in the development of acne vulgaris by increasing sebum production. The aim of this study was to reveal the changes in CBC sub-parameters and calculated parameters before and after acne vulgaris treatment and to enable these parameters to be used as non-invasive, low-cost, effective new laboratory tests in the evaluation of treatment efficacy. A total of 162 patients (109 females, 67.3%; 53 males, 32.7%) were included in this study. In this study, it was found that NEU, MPV, P-LCR, and PDW levels decreased significantly after treatment (p<0.001). There was a significant decrease in NLR and PLR values (p<0.001). LYM and PLT count increased significantly after the treatment (p<0.001). CBC parameters such as NLR, PLR, and P-LCR can be used to evaluate the efficacy of systemic isotretinoin treatment in patients with acne vulgaris.

show abstract

Effect of isotretinoin treatment on the inflammatory markers in patients with acne vulgaris: can monocyte/HDL be a new indicator for inflammatory activity of isotretinoin treatment?

Cited by 17 publications

References 24 publications

Increases in uric acid and monocyte‐high‐density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin

Increases in uric acid and monocyte‐high‐density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

Akne Vulgaris Hastalarında Tedavinin Hematolojik Parametreler Üzerine Etkisi

Contact Info

Product

Resources

About