From April 5th to 12th, 2020, between the 25th and 32nd days after the first COVID-19 case in Turkey, a self-administered online questionnaire (SurveyMonkey®) consisting of 90 questions was conducted for doctors and nurses that voluntarily participated in the study. We aimed to reduce the risk of bias in the questions posed to the participants by carrying out this retrospective study in the early phase of the COVID-19 outbreak. The first part of the questionnaire examined subjects such as demographic characteristics, occupational and institutional information, medical history,
We aim to evaluate the change in the diagnostic spectrum in dermatology outpatient applications compared to before COVID‐19. All patients were enrolled from the Department of Dermatology between February 12 and May 8, 2020, the duration of 4 weeks before COVID‐19 and 8 weeks after were analyzed in three parts consisting of 4 weeks. Data obtained from the database such as age, gender, diagnoses were anonymized. Repeated applications with the same diagnosis in 10 days after the first presentation were ignored. Compared to the pre‐outbreak, there was a 3.5‐fold decrease in dermatology applications in the first month after COVID‐19 and an 8.8‐fold in the second month. We found a significant increase in the frequency of diagnoses such as generalized pruritus, pityriasis rosea, alopecia areata, bacterial skin/mucosa diseases, and zona zoster after COVID‐19. The frequency declined in diseases such as verruca vulgaris, hyperpigmentation, skin tag, melanocytic nevus, and seborrheic keratosis/solar lentigo. It has been found that the frequencies of most diseases, including acne (⁓25% of patients), did not change. We think that many factors, such as affecting the quality of life, risk perception, increased stress burden may cause a change in the diagnostic distribution of the dermatology applications.
Coronavirus Disease-2019 (COVID-19) spread rapidly worldwide in about three months and was declared a pandemic by the World Health Organization on March 11, 2020. It was reported that more than 80 million people had been infected, and more than 1.8 million patients had died of COVID-19 by the end of December 2020. 1 Due to the rapid spread and fatal course of the infection, the search
Recurrent oral ulcers (ROUs) are the most common disorder of the oral cavity in the community. Although many etiological causes such as trauma, genetic, nutritional, infectious, immune, drug-mediated, rheumatological, endocrinological have a role, it is commonly idiopathic, known as recurrent aphthous stomatitis (RAS). 1-3 Indeed, RAS has accounted for 25% of oral ulcers in adults and 40% in children. 2 The most challenging issue for the clinician to deal with in the diagnosis is to distinguish whether oral ulcers are associated with primarily Behçet's disease (BD) and other systemic inflammatory processes such as inflammatory bowel diseases and connective
Purpose
We aimed to reveal the relationship of serum uric acid (SUA) with monocyte‐high‐density lipoprotein ratio (MHR) and other inflammatory markers in acne patients before and after isotretinoin treatment. In this way, we can try to shed light on the relationship between isotretinoin treatment and atherosclerosis.
Methods
Two hundred twenty‐four acne patients who administered isotretinoin (0.5‐1 mg/kg/day) were enrolled in the study. In the pretreatment phase and 3 months after treatment, MHR, SUA, mean platelet volume, neutrophil‐lymphocyte ratio (NLR), platelet‐lymphocyte ratio, monocyte‐lymphocyte ratio, serum triglyceride, total cholesterol, high‐density lipoprotein (HDL), and low‐density lipoprotein (LDL) levels of the patients were analyzed.
Results
Compared to the pretreatment phase, three months after treatment, there was a statistically decrease in neutrophil count and an increase in lymphocyte count (p: 0.002, p: 0.011, respectively). Accordingly, there was a statistically significant decrease in NLR (p: 0.001). It was noteworthy that MHR and SUA levels increased significantly (p: 0.042, p: 0.010, respectively) and there was a positive correlation between SUA level and MHR (r: 0.212, p: 0.012). Serum total cholesterol, LDL, and triglyceride levels increased and HDL levels decreased significantly after treatment (p: 0.001).
Conclusion
This study contributes to the comprehension of the relationship between isotretinoin treatment and atherosclerosis, which has been frequently reported in the literature. It was thought that the isotretinoin‐induced SUA increase might be related to dyslipidemia. Isotretinoin may initiate the atherosclerotic process in vascular endothelial and smooth muscles, with SUA increase and HDL decrease. An increase in MHR is also an inflammatory marker indicating this process.
Introduction: Systemic sclerosis (SSc) or scleroderma is a clinically heterogeneous disease. Autoantibodies associated with different clinical features may help in predicting organ involvement. Complete blood count (CBC) parameters and neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), and platelet/lymphocyte (PLR) ratios, which are considered biomarkers of systemic inflammation, have been reported many times in various rheumatologic diseases. Studies related to the usefulness of the CBC to assess the severity of SSc are still lacking. This study seeks to determine whether CBC parameters associated with organ involvement, when evaluated together with clinical features and autoantibodies, can additionally contribute to risk estimation. Methods: Adult patients with SSc (n = 130) and healthy control (n = 129) groups were enrolled in the study. Epidemiological, clinical, laboratory, and radiological findings were obtained by examining patient records. Results: PLR, NLR, and MLR were related to organ involvement. Statistically significant results were obtained with hemoglobin (≤ 13.0 g/dl), lymphocyte count (≤ 1,900 × 10 3 /ml), and mean platelet volume (≤ 8.0 fl) to estimate the risk of interstitial lung disease (p < 0.05). When the lymphocyte count was 1,400 (10 3 /ml) or less, there was a significantly greater risk of pulmonary hypertension. Neutrophil volume ≤ 141 indicated gastrointestinal tract involvement. Conclusions: Simple hematological parameters can be used for predicting SSc-related organ involvements.
Pediatricians and dietitians should train the adolescents living in our region and our country on practical strategies for making healthy food choices rich in nutrient content relative to energy value to ensure intakes that approach the recommendations.
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