Effect of intrauterine ischaemia-reperfusion injury on rat skin

Abstract

Lipid peroxidation has an important role in intrauterine ischaemia-reperfusion-induced fetal skin damage in rats.

Protective effect of dexamethasone on fetal rat skin in experimental intrauterine ischaemia/reperfusion injury

“…We recently showed that fetal skin is vulnerable to intrauterine I/R injury when lipid peroxidation values increased after I/R injury. 10 Consistent with our previous work, we found in the current study that levels of TBARS, MPO and NO increased significantly in fetal skin tissue after intrauterine I/R injury. Our findings suggest that IR injury to fetal skin, causing an increase in TBARS levels, could also affect DNA, 17 and potentially cause conditions such as vitiligo, 18 lichen planus, 19 atopic dermatitis, 20 rosacea, 21 skin cancer 22 and ageing 22 in which reactive oxygen species have been shown to be involved.…”

“…There are few data describing the effect of intrauterine I/R injury on fetal skin. We recently showed that fetal skin is vulnerable to intrauterine I/R injury when lipid peroxidation values increased after I/R injury . Consistent with our previous work, we found in the current study that levels of TBARS, MPO and NO increased significantly in fetal skin tissue after intrauterine I/R injury.…”

“…Perinatal hypoxia and resultant ischaemia/reperfusion (I/R) injury may also result in damage to multiple organs, including the brain, heart, liver and gastrointestinal tract . Recently, fetal skin has been shown to be vulnerable to intrauterine I/R injury when lipid peroxidation values, as measured by thiobarbituric acid reactive substances (TBARS) were raised in fetal rat skin after I/R insult …”

“…9 Recently, fetal skin has been shown to be vulnerable to intrauterine I/R injury when lipid peroxidation values, as measured by thiobarbituric acid reactive substances (TBARS) were raised in fetal rat skin after I/R insult. 10 A number of drugs have been tested for their protective effect in intrauterine I/R injury, including erythropoetin, propofol, nifepidipine and MK801. 11,12 The protective effects of corticosteroids on various tissues are well known, and corticosteroids have been used to protect against intrauterine I/R injury to the brain 6 or against development of neonatal necrotizing enterocolitis.…”