Magnesium sulfate protects fetal skin from intrauterine ischemia reperfusion injury

Kaptanoğlu, Aslı Feride; Arca, Turkan; Kılınç, Kamer

doi:10.1007/s00403-012-1217-5

Cited by 5 publications

(5 citation statements)

References 14 publications

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“… 30 Kaptanoglu et al demonstrated that administration of magnesium reduced the I/R injury on fetal rat skin. 31 A free radical reducing effect of magnesium in a coronary occlusion reperfusion model was demonstrated by Garcia et al 32 It was also demonstrated that magnesium reduces the lactate and MDA levels after cerebral ischemia. 33 It was shown that application of Lomodex–MgSO 4 prior to detorsion increases semen quality and fertility.…”

Section: Discussionmentioning

confidence: 89%

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Kavak¹,

Bulmus²,

Bulmuş³

et al. 2018

DDDT

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AimThe aim of the present study was to assess the protective effects of magnesium sulfate (MgSO4) on ischemia/reperfusion (I/R) induced ovarian damage in a rat ovarian torsion model.MethodsForty-two female Sprague Dawley rats were included in the study. They were divided into six groups as Group 1, sham; Group 2, bilateral ovarian torsion; Group 3, bilateral ovarian torsion–detorsion; Group 4, MgSO4–sham; Group 5, MgSO4–bilateral ovarian torsion; Group 6, bilateral ovarian torsion–MgSO4–detorsion. Both torsion and detorsion periods lasted 3 hours. In Groups 4, 5 and 6, MgSO4 (600 mg/kg) was administered by intraperitoneal route 30 minutes before sham operation, torsion and detorsion, respectively. At the end of the study period, both ovaries were removed. One of the ovaries was used for histopathological analyses and the other for biochemical analyses.ResultsIn the torsion–detorsion group, all the histopathological scores were higher compared to the sham and torsion only group (p<0.05). Administration of MgSO4 only caused significant decrease in the inflammatory cell scores of the torsion–detorsion group (p<0.05). MgSO4, whether given before torsion or before detorsion, suppressed malondialdehyde levels when compared to the untreated groups (p<0.01 and p<0.001, respectively). Glutathione peroxidase activities were significantly higher in the MgSO4 applied torsion and detorsion groups than Groups 2 and 3 (p<0.05, for both). Administration of MgSO4 also caused an increase in glutathione levels in the torsion and detorsion groups compared to the torsion only and detorsion only groups (p<0.05, for both). Also, total oxidant status levels decreased in the MgSO4 applied torsion and detorsion groups compared to the untreated corresponding ones (p<0.01 and p<0.001, respectively). MgSO4 significantly decreased the Oxidative Stress Index levels in the torsion–detorsion group compared to Group 2 (p<0.001).ConclusionHistopathological and biochemical analysis revealed that prophylactic treatment with MgSO4 reduces the changes observed in I/R injury in a rat model.

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Section: Discussionmentioning

confidence: 89%

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Kavak¹,

Bulmus²,

Bulmuş³

et al. 2018

DDDT

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“…It was suggested that magnesium, an L-type calcium channel blocker, may be effective in preventing IR damage by reducing calcium overload related to tissue damage [6][7][8][9]. There are studies showing that magnesium sulfate is used at different doses in different organ irradiation therapies [6][7][8]20]. In our study, magnesium sulfate was administered 200 mg/kg intraperitoneally 20 minutes before ischemia.…”

Section: Discussionmentioning

confidence: 94%

“…Magnesium sulfate inhibits endotoxin-dependent inflammatory molecule up-regulation. It was suggested that magnesium, an L-type calcium channel blocker, may be effective in preventing IR damage by reducing calcium overload related to tissue damage [6][7][8][9]. There are studies showing that magnesium sulfate is used at different doses in different organ irradiation therapies [6][7][8]20].…”

Section: Discussionmentioning

confidence: 99%

“…It inhibits up-regulation of endotoxin-dependent inflammatory molecule. Magnesium is an L-type calcium channel blocker and may be effective in preventing I/R damage by reducing calcium overload associated with tissue damage in this manner [6][7][8][9]. The literature is lacking knowledge about the protective efficacy of magnesium sulfate in the rat liver I/R injury model.…”

Section: Introductionmentioning

confidence: 99%

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Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model

Akkoca

Yoldaş

Şit

et al. 2019

j-ebr

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To investigate the protective efficacy of magnesium sulphate in a model of rat liver ischemiareperfusion (I/R) injury. Method: 32 adult female Wistar-Albino rats (250 to 350 g) were used in this experimental study. Rats were divided into 4 groups according to liver ischemia and magnesium sulfate application methods. Group 1 (C); control, group 2 (M); magnesium sulphate, group 3 (I/R); liver I/R, group 4 (I/R+M); I/R + magnesium sulphate treated. The blood samples were centrifuged for the study of aspartate aminotransferase (AST), alanine aminotransferase, prothrombin time (PT), international normalized ratio (INR) troponin I, total antioxidant status (TAS), total oxidant status (TOS) assays. The livers of the animals were removed at the end of the study and samples were taken for histopathological examination. Results: AST and INR values were significantly decreased in I/R+M group compared to I/R group. There was no significant difference in ALT values of the groups. Although not statistically significant, the TAS values were increased in I/R + M group compared to I/R group rats. In addition, the value of TOS was found to be lower in I/R + M group rats. In the histopathological examination, the mean values of apoptosis and necrosis were lower in the IR+M group compared to the I/R group. Conclusion:The main finding of the present study suggested that magnesium sulphate pretreatment moderately decreased the liver damage through its anti-inflammatory and anti-oxidant effects in a rat model of liver I/R.

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“…Its microbiome and its physical, chemical, and immune barriers constitute an interactive network that protects individuals from external harm [ 21 ]. The 5 elements tested in the current study strongly influence the functions of skin, with effects on wound healing [ 22 , 23 ], scar formation and contraction [ 24 ], microvasculature blood flow [ 25 , 26 ], and immune function [ 27 ]. A deficiency of these 5 elements may cause skin lesions [ 28 – 30 ], while supplementation may lead to improved skin functions [ 21 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Lower Metal Element Levels in Hypertrophic Scars: A Potential Mechanism of Aberrant Cicatrix Hyperplasia

et al. 2020

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Background We investigated levels of the metal elements Ca, Mg, Zn, Fe, and Cu in blood, normal skin (NS), and different types of scar tissue and aimed to elucidate the pathogenesis of hypertrophic scars (HS). Material/Methods Tissue specimens were excised from 3 groups of research participants: scar-free, flat scar (FS), and HS groups. Levels of the study elements were measured in blood, NS, and scar tissues with a spectrophotometer. The levels in plasma or in different types of specimens were compared among subgroups. In the FS and HS groups, levels were compared between the scar tissue and NS of each individual. In addition, element differences in exposed and unexposed areas of NS were investigated in the scar-free group. HS fibroblasts (HFB) were cultured in medium with various reduced levels of metal elements to determine the influence of metal elements on fibroblast growth. Results Levels of trace elements, including Zn, Fe, and Cu, were significantly lower in HS than in FS. The levels of Ca, Zn, Fe, and Cu were markedly lower in HS than in the patients’ own NS, while the Cu/Zn ratio was higher. However, no such difference was observed in the FS group. No significant difference in element levels was found in either plasma or NS among the 3 groups. Reduced levels of the elements promoted HFB proliferation within 24 h while an inhibition effect was observed at 72 h. Conclusions Our findings indicate reduced levels of metal elements in part of the healing microenvironment, suggesting that decreased metal levels may be involved in the pathogenesis of HS.

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Magnesium sulfate protects fetal skin from intrauterine ischemia reperfusion injury

Cited by 5 publications

References 14 publications

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?

Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model

Lower Metal Element Levels in Hypertrophic Scars: A Potential Mechanism of Aberrant Cicatrix Hyperplasia

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