Effect of flunixin meglumin on the antioxidant status in endotoxemia

Konyalιoğlu, Sibel; Er, Ayşe; Üney, Kamil; Elmas, Muammer; Yazar, Enver

doi:10.2298/avb0703241k

Cited by 15 publications

(1 citation statement)

References 18 publications

(19 reference statements)

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“…Normally, oxidants and antioxidants are in balance in the body. The NSAIDs can alter oxidative balance in the body (Konyalioglu et al, 2007). The mechanism of diclofenac-induced mitochondrial injury may be involved in the generation of ROS, causing renal tissue oxidative stress (Hickey et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Hematological and renoprotective effects of folic acid and lentil extract in diclofenac sodium exposed rats

Abdel-Rahman

Abdel-Baky

2023

Braz. J. Biol.

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Excessive intake of non-steroidal anti-inflammatory drugs such as, diclofenac sodium (DS) may lead to toxicity in the rats. In this work, we aimed to examine the protective impact of lentil extract (LE) and folic acid (FA) on the hematological markers, the kidney tissue oxidative stress and the renal function against diclofenac sodium (DS) in male albino rats. The rats (120-150 g) were divided into four equal groups randomly, the first group kept as the untreated control. The second group was administrated with DS (11.6 mg/kg b.wt. orally once/day). The third group was received DS+FA (11.6 mg/kg b.wt.+76.9 microgram/kg b.wt.) orally once/day. The fourth group was treated with DS+LE (11.6 mg/kg b.wt.+500 mg/kg b.wt.) orally once/day. After four weeks, the results revealed that DS produced a significant decrease in the values of red blood cells (RBCs), hemoglobin concentration (Hb), hematocrit (HCT) and white blood cells (WBCs). On the other hand, there was a significant increase in the platelets count. Also, DS induced a renal deterioration; this was evidenced by the significant increase in the serum levels of urea, creatinine, uric acid, Na, Ca, Mg as well as the nitric oxide (NO) level in the kidney tissue. Also, there were a significant reduction in the serum levels of potassium (K) and reduced glutathione (GSH) in the kidney homogenates. Moreover, the findings in the rats treated by DS+LE or DS+FA showed a potential protection on the hematological markers, oxidative stress in the kidney tissue and the renal function disturbed by DS. LE and FA could play a potent role for the prevention the adverse hematological, the kidney tissue oxidative stress and the renal dysfunction caused by DS via their anti-oxidative and bioactive phytochemicals.

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Section: Discussionmentioning

confidence: 99%

Hematological and renoprotective effects of folic acid and lentil extract in diclofenac sodium exposed rats

Abdel-Rahman

Abdel-Baky

2023

Braz. J. Biol.

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Anti-inflammatory effects of insulin regular and flunixin meglumine on endotoxemia experimentally induced by Escherichia coli serotype O55:B5 in an ovine model

et al. 2012

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As a painkiller: a review of pre- and postnatal non-steroidal anti-inflammatory drug exposure effects on the nervous systems

Yurt

Kaplan

2017

Inflammopharmacol

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Diclofenac sodium (DS) is commonly used for the treatment of acute and chronic pain, even for extended periods of time. Over the years, DS has been associated with toxicity in nervous tissue, in addition to its anti-inflammatory properties. Basic neurobiological research has enhanced our understanding of the biological and pathological outcomes of toxicity. Several studies have suggested DS-induced cytotoxicity in the nervous system. Prenatal toxicities of DS are thought to be capable of leading to postnatal defects. This review describes the morphoquantitative, histological and pathological effects of DS on the central and peripheral nervous systems. Knowledge of these effects may assist with the development of a suitable therapeutic approach. In addition, understanding the mechanism of DS-dependent neuronal impairments may contribute to selection of appropriate antioxidant therapy.

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Effect of flunixin meglumin on the antioxidant status in endotoxemia

Cited by 15 publications

References 18 publications

Hematological and renoprotective effects of folic acid and lentil extract in diclofenac sodium exposed rats

Hematological and renoprotective effects of folic acid and lentil extract in diclofenac sodium exposed rats

Anti-inflammatory effects of insulin regular and flunixin meglumine on endotoxemia experimentally induced by Escherichia coli serotype O55:B5 in an ovine model

As a painkiller: a review of pre- and postnatal non-steroidal anti-inflammatory drug exposure effects on the nervous systems

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