As a painkiller: a review of pre- and postnatal non-steroidal anti-inflammatory drug exposure effects on the nervous systems

Yurt, Kıymet Kübra; Kaplan, Süleyman

doi:10.1007/s10787-017-0434-0

Cited by 9 publications

(4 citation statements)

References 127 publications

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“…Comparing Groups C to A and B, the improved functional recovery and the potential reparative role of the anti-inflammatory DS [40] and neurotrophic NGF in the treatment of peripheral nerve injuries was noted. Despite the slight positive effect noted in this study, the benefit of DS and other nonsteroidal anti-inflammatory agents for peripheral nerve regeneration and neuroprotection requires further dose-dependent mechanistic studies [41]. Groups D and E, compared to the other groups, demonstrated improved functional recovery, attributed to the intraluminal fibers as a physical guidance cue.…”

Section: Functional Recovery Evaluationmentioning

confidence: 59%

Gellan-Xanthan Hydrogel Conduits with Intraluminal Electrospun Nanofibers as Physical, Chemical and Therapeutic Cues for Peripheral Nerve Repair

Ramburrun

Kumar

Ndobe

et al. 2021

IJMS

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Optimal levels of functional recovery in peripheral nerve injuries remain elusive due to the architectural complexity of the neuronal environment. Commercial nerve repair conduits lack essential guidance cues for the regenerating axons. In this study, the regenerative potential of a biosimulated nerve repair system providing three types of regenerative cues was evaluated in a 10 mm sciatic nerve-gap model over 4 weeks. A thermo-ionically crosslinked gellan-xanthan hydrogel conduit loaded with electrospun PHBV-magnesium oleate-N-acetyl-cysteine (PHBV-MgOl-NAC) nanofibers was assessed for mechanical properties, nerve growth factor (NGF) release kinetics and PC12 viability. In vivo functional recovery was based on walking track analysis, gastrocnemius muscle mass and histological analysis. As an intraluminal filler, PHBV-MgOl-NAC nanofibers improved matrix resilience, deformation and fracture of the hydrogel conduit. NGF release was sustained over 4 weeks, governed by Fickian diffusion and Case-II relaxational release for the hollow conduit and the nanofiber-loaded conduit, respectively. The intraluminal fibers supported PC12 proliferation by 49% compared to the control, preserved up to 43% muscle mass and gradually improved functional recovery. The combined elements of physical guidance (nanofibrous scaffolding), chemical cues (N-acetyl-cysteine and magnesium oleate) and therapeutic cues (NGF and diclofenac sodium) offers a promising strategy for the regeneration of severed peripheral nerves.

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Section: Functional Recovery Evaluationmentioning

confidence: 59%

Gellan-Xanthan Hydrogel Conduits with Intraluminal Electrospun Nanofibers as Physical, Chemical and Therapeutic Cues for Peripheral Nerve Repair

Ramburrun

Kumar

Ndobe

et al. 2021

IJMS

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“…Therefore, future studies should include patients with other migraine subtypes and in other phases. Third, hormone levels and concomitant psychiatric diseases could potentially exacerbate migraine, influence treatment response and complicate migraine treatment ( Yurt and Kaplan, 2018 ; Radat, 2021 ). Therefore, future studies should investigate the influence of the hormone profile and psychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

Disrupted Functional Connectivity of the Amygdala Predicts the Efficacy of Non-steroidal Anti-inflammatory Drugs in Migraineurs Without Aura

Wei

Wang

et al. 2022

Front. Mol. Neurosci.

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Machine learning (ML) has been largely applied for predicting migraine classification. However, the prediction of efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) in migraine is still in the early stages. This study aims to evaluate whether the combination of machine learning and amygdala-related functional features could help predict the efficacy of NSAIDs in patients with migraine without aura (MwoA). A total of 70 MwoA patients were enrolled for the study, including patients with an effective response to NSAIDs (M-eNSAIDs, n = 35) and MwoA patients with ineffective response to NSAIDs (M-ieNSAIDs, n = 35). Furthermore, 33 healthy controls (HCs) were matched for age, sex, and education level. The study participants were subjected to resting-state functional magnetic resonance imaging (fMRI) scanning. Disrupted functional connectivity (FC) patterns from amygdala-based FC analysis and clinical characteristics were considered features that could promote classification through multivariable logistic regression (MLR) and support vector machine (SVM) for predicting the efficacy of NSAIDs. Further, receiver operating characteristic (ROC) curves were drawn to evaluate the predictive ability of the models. The M-eNSAIDs group exhibited enhanced FC with ipsilateral calcarine sulcus (CAL), superior parietal gyrus (SPG), paracentral lobule (PCL), and contralateral superior frontal gyrus (SFG) in the left amygdala. However, the M-eNSAIDs group showed decreased FC with ipsilateral caudate nucleus (CAU), compared to the M-ieNSAIDs group. Moreover, the M-eNSAIDs group showed higher FC with left pre-central gyrus (PreCG) and post-central gyrus (PoCG) compared to HCs. In contrast, the M-ieNSAIDs group showed lower FC with the left anterior cingulate cortex (ACC) and right SFG. Furthermore, the MwoA patients showed increased FC with the left middle frontal gyrus (MFG) in the right amygdala compared to HCs. The disrupted left amygdala-related FC patterns exhibited significant correlations with migraine characteristics in the M-ieNSAIDs group. The MLR and SVM models discriminated clinical efficacy of NSAIDs with an area under the curve (AUC) of 0.891 and 0.896, sensitivity of 0.971 and 0.833, and specificity of 0.629 and 0.875, respectively. These findings suggest that the efficacy of NSAIDs in migraine could be predicted using ML algorithm. Furthermore, this study highlights the role of amygdala-related neural function in revealing underlying migraine-related neuroimaging mechanisms.

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“…Diclofenac sodium acts by inhibiting cyclooxygenase-2 (COX-2) (19,20). Some studies have shown it to modulate collagen synthesis by inhibiting prostaglandin E2 (PGE-2) and reducing fi broblast proliferation in colon cells.…”

Section: Introductionmentioning

confidence: 99%

Preventative effect of diclofenac sodium and/or diltiazem in rats with epidural fibrosis

Erdoğan¹,

Is²,

Aker³

et al. 2019

BLL

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OBJECTIVE: Spinal epidural fi brosis is commonly seen after laminectomy. There is not yet proven any agent preventing fi brosis in clinical usage. We used diclofenac sodium and diltiazem, which are fi brosis inhibitors. METHODS AND MATERIALS: 40 rats were divided into four groups of equal numbers: control, diclofenac sodium, diltiazem, and diclofenac sodium + diltiazem. Laminectomies were performed at L5 and L6. After a 4 week period, the rats were decapitated and the vertebral column blocks were removed for histopathologic examination. Fibrosis percentage, spread of fi brous regions, and fi broblast numbers were evaluated in each group and compared between the groups. RESULTS: The distribution of epidural fi brosis density, percentage of fi brosis, and distribution of fi broblasts in the diclofenac sodium + diltiazem group were signifi cantly lower than in the other groups. The fi broblast numbers of the diltiazem, and diclofenac sodium + diltiazem groups were signifi cantly lower than in the other groups. CONCLUSION: Diclofenac sodium + diltiazem used together provided better outcomes because each of them prevented fi brosis via different ways, probably through synergistic action (Tab.

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As a painkiller: a review of pre- and postnatal non-steroidal anti-inflammatory drug exposure effects on the nervous systems

Cited by 9 publications

References 127 publications

Gellan-Xanthan Hydrogel Conduits with Intraluminal Electrospun Nanofibers as Physical, Chemical and Therapeutic Cues for Peripheral Nerve Repair

Gellan-Xanthan Hydrogel Conduits with Intraluminal Electrospun Nanofibers as Physical, Chemical and Therapeutic Cues for Peripheral Nerve Repair

Disrupted Functional Connectivity of the Amygdala Predicts the Efficacy of Non-steroidal Anti-inflammatory Drugs in Migraineurs Without Aura

Preventative effect of diclofenac sodium and/or diltiazem in rats with epidural fibrosis

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