Effect of enriched environment and predictable chronic stress on spatial memory in adolescent rats: Predominant expression of BDNF, nNOS, and interestingly malondialdehyde in the right hippocampus

Kaptan, Zulal; Dar, Kadriye Akgün; Kapucu, Ayşegül; Bulut, Huri; Üzüm, Gülay

doi:10.1016/j.brainres.2019.146326

Cited by 12 publications

(10 citation statements)

References 71 publications

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“…Many strategies, both pharmacological and non-pharmacological, have been used to promote cognitive and structural reserves. Among them, lifestyle changes, also known as environmental enrichment, is widely known to promote memory preservation and decrease Aβ plaque in animal models of AD (Jankowsky et al, 2005 ; Balthazar et al, 2018 ), while also increasing the production of BDNF (Baraldi et al, 2013 ; Dong et al, 2018 ; Kaptan et al, 2019 ), suggesting that improvements in cognitive performance and neurogenesis are related to a more active life (Garthe et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice

Malerba

Pereira

Pierrobon

et al. 2021

Front. Aging Neurosci.

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Increase in the quality of life, combined with drug strategies, has been studied as possibilities for improving memory and delaying the onset of neurodegenerative diseases. A previous study published by the group of the authors has shown that microdose lithium and enriched environment can improve memory in both mice and humans. To elucidate this relationship better, this study aimed to evaluate whether the chronic combination of these two strategies could increase healthy aging in Senescence Accelerated Mouse-Prone 8 (SAMP8). Animals were submitted to either one or both of these strategies until the age of 10 months when they were anesthetized and killed and their hippocampus was extracted. The untreated SAMP-8 group exhibited worse memory and reduced neuronal density with greater neurodegeneration and increased amyloid-β plaque density compared with the control group. Moreover, significant alterations in proteins related to long-term potentiation, such as, synaptophysin and brain-derived neurotrophic factor (BDNF), were observed in this group. The strategies used in the study maintained long-term memory, reduced anxiety, and increased neuroprotection. Both strategies were efficient in reducing neurodegeneration and increasing parameters related to memory maintenance. In many experiments, the combination of the two strategies was more effective in improving healthy aging. This study sheds light on the combination of strategies that choose to improve the quality of life and drugs with low side effects. Moreover, it opens perspectives for a new field of study for healthy aging.

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Section: Introductionmentioning

confidence: 99%

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice

Malerba

Pereira

Pierrobon

et al. 2021

Front. Aging Neurosci.

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“…BDNF expression in CPF was not significantly different from the control group [18]. Research Kaptan et al (2019) predictable chronic stress increases BDNF expression in the hippocampus. Stress causes MDA levels to increase in the hippocampus, nNOS increases in the CA1, CA3 hippocampus and dentate gyrus areas.…”

Section: Discussionmentioning

confidence: 62%

Propolis Increases Brain Derived Neurotrophic Factor Expression in the Prefrontal Cortex of Rat Stress Model

Kuswati¹,

Handayani²,

Nugraha³

2022

Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)

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Stress causes an increase in glucocorticoid hormones and glutamat release in the central nervous system. This condition can increase calcium influx in the neuron, mitochondrial membrane permeability and triggers apoptosis, thereby reducing the number of neurons. In the prefrontal cortex, stress exposure increase bax expression and decrease in the number of neurons. Stress causes decrease in the expression of brain derived neurotrophic factor (BDNF). To determine neuroprotective effect of propolis on BDNF expression in the prefrontal cortex of rat stress model. Experimental study with male Spraque-Dawley rats, aged 2-4 months and weighing 200-300 g. Rats were randomly divided into 4 groups, each group consisted of 5 rats (n = 5). Group K is the stress group, Groups P1, P2 and P3 are the stress group and propolis therapy with doses of 100, 150 and 200 and mg/kgbb, respectively. Stress treatment and administration of propolis for 14 days. On the 15th day, rats was decapitation and brain tissue taken. Brain tissue was made histological preparations with immunohistochemical staining using bdnf antibody. Observations using a light microscope with a magnification of 1000 times. Statistical data analysis using one way Anova. Group K showed the lowest bdnf expression. The highest bdnf expression was in the P2 group. There was a significant difference in groups K and P2 (p. 0.020). Propolis 150 mg/kgbw increase bdnf expression in the prefrontal cortex of rat stress model..

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“…This response might be similar to that found in paradigms of chronic predictable stress. Thus, daily immobilization stress for 7 days generated increased baseline corticosterone levels 73 , while a similar but milder paradigm lasting 4 weeks did not 74 .…”

Section: Discussionmentioning

confidence: 89%

Restricted cafeteria feeding and treadmill exercise improved body composition, metabolic profile and exploratory behavior in obese male rats

Alvarez-Monell

Subias-Gusils

Mariné-Casadó

et al. 2022

Sci Rep

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The aim of this study was to evaluate, in male Long-Evans rats, whether a restricted-cafeteria diet (CAFR), based on a 30% calorie restriction vs continuous ad libitum cafeteria (CAF) fed animals, administered alone or in combination with moderate treadmill exercise (12 m/min, 35 min, 5 days/week for 8 weeks), was able to ameliorate obesity and the associated risk factors induced by CAF feeding for 18 weeks and to examine the changes in circadian locomotor activity, hypothalamic–pituitary–adrenal (HPA) axis functionality, and stress response elicited by this dietary pattern. In addition to the expected increase in body weight and adiposity, and the development of metabolic dysregulations compatible with Metabolic Syndrome, CAF intake resulted in a sedentary profile assessed by the home-cage activity test, reduced baseline HPA axis activity through decreased corticosterone levels, and boosted exploratory behavior. Both CAFR alone and in combination with exercise reduced abdominal adiposity and hypercholesterolemia compared to CAF. Exercise increased baseline locomotor activity in the home-cage in all dietary groups, boosted exploratory behavior in STD and CAF, partially decreased anxiety-like behavior in CAF and CAFR, but did not affect HPA axis-related parameters.

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Effect of enriched environment and predictable chronic stress on spatial memory in adolescent rats: Predominant expression of BDNF, nNOS, and interestingly malondialdehyde in the right hippocampus

Cited by 12 publications

References 71 publications

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice

Propolis Increases Brain Derived Neurotrophic Factor Expression in the Prefrontal Cortex of Rat Stress Model

Restricted cafeteria feeding and treadmill exercise improved body composition, metabolic profile and exploratory behavior in obese male rats

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