Effect of dietary copper source (inorganic <i>vs.</i> chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets

Liao, Peng; Shu, Xugang; Tang, Min; Tan, Bin; Yin, Yulong

doi:10.1080/09540105.2017.1416068

Cited by 12 publications

(24 citation statements)

References 45 publications

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“…These data are confirmed by the results of the present study, in which the highest serum Cu concentration was noted in the group of chickens receiving a copper-glycine chelate. The results are consistent with those previously published by Liao et al (2018), who showed that supplementation of pig feed with copper in complexes with lysine increased its concentration in the plasma. Similarly, in the present study the highest concentration of copper in the muscle tissue, liver and intestines were noted in the group of birds whose feed contained a copper-glycine chelate with phytase.…”

Section: Discussionsupporting

confidence: 93%

The effect of feed supplementation with a copper-glycine chelate and copper sulphate on cellular and humoral immune parameters in chickens

Jarosz

Ciszewski

Grabowski

et al. 2021

Food and Agricultural Immunology

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Copper has been shown to plays an important role in immune functions. The aim of the study was to determine the effect of inorganic and organic forms of copper on the concentrations of cytokines, acute phase proteins and prostanoids in the peripheral blood and liver of poultry. The concentration of copper in serum and tissues was also determined. A total of 900 1-day-old Ross 308 male chickens were used. The rearing period was 42 days. The material for analysis comprised samples of peripheral blood, liver, intestine and muscle of experimental chickens. The obtained results indicate that the supplementation of broilers feed with copper chelates promotes secretion of pro and anti-inflammatory cytokines. Increased synthesis of the immunoregulatory serum amyloid A (SAA) and alpha-1-acid glycoprotein (α-AGP) and prostanoids following the administration of copper-glycine chelates in the diet indicates the stimulatory effect of copper on cellular and humoral immune mechanisms.

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Section: Discussionsupporting

confidence: 93%

The effect of feed supplementation with a copper-glycine chelate and copper sulphate on cellular and humoral immune parameters in chickens

Jarosz

Ciszewski

Grabowski

et al. 2021

Food and Agricultural Immunology

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“…The supplementation of high copper diets in growing pigs may result in the increased in copper accumulation in organs and excretion in manure, which poses both health and environmental risk (Kornegay and Verstegen, 2001). The excretion of high copper levels in swine manure is reported elsewhere (Yin et al, 2018;Zheng et al, 2018;Liao et al, 2018). Thus, it is important to examine the effects of dietary supplementation of copper on the relative distribution and accumulation of copper in organs and total copper content in fattening pigs.…”

Section: Discussionmentioning

confidence: 99%

Effects of High Dietary Copper Supplementation on the Copper Accumulation and Total Copper Content in Fattening Pigs

Adams¹,

Yang²,

Che³

et al. 2019

Appl. Ecol. Env. Res.

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The objective of this current study was to investigate the effects of high dietary copper supplementation on the tissue copper deposition, distribution, and total copper concentration in fattening pigs. A total of 24 (Landrace × Large white × Duroc) pigs with an average initial body weight (BW) of 30 ± 1.05 kg were selected for the current experiment. At the beginning of the experiment, the pigs were randomly divided into four treatment groups with three replicate pens per treatment and two pigs per replicate and arranged in accordance to a completely randomized design based on the BW. The four treatment administered were as follows: 10 mg/kg, 45 mg/kg, 135 mg/kg, and 225 mg/kg of copper. The result indicates that the copper content in the liver, kidney, and heart increased with the increase in dietary copper composition. There was no significant difference in the copper content of the different visceral tissues in the 10 mg/kg treatment group. However, when the copper levels increased to 45 mg/kg and 135 mg/kg, the copper content in the liver was significantly higher than that in the other visceral tissues (P < 0.05). At 225 mg/kg dietary copper, there was a significant increase in the copper content of the foreleg muscle. There was no significant difference in copper content of the rib bones, tibia bones, and femur bone marrow copper accumulation between the 10 mg/kg copper and the 45 mg/kg copper fed pigs. In addition, there was no significant difference in the brain, blood, cerebellum, and skin copper content within all the treatment groups. Therefore, dietary copper levels increased with the increase in total copper accumulation in pigs. Hence, higher dietary copper supplementation increased liver, kidney, heart, fur, bones, bone marrow copper accumulation and total copper levels in fattening pigs.

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“…Therefore, reduced expression of MUC2 in piglets from sows fed a diet with MMHAC could also indicate that nutrients to make mucin could be saved potentially directing more nutrients for the growth of their piglets. Previous studies showed that chelated mineral sources can regulate intestinal inflammatory response ( Liao et al, 2018 ; Shannon and Hill, 2019 ). The intestinal inflammatory response can be caused by various stimuli, such as viral antigen, bacteria invasion, cytokines, stress, and free radicals.…”

Section: Discussionmentioning

confidence: 99%

Effects of mineral methionine hydroxy analog chelate in sow diets on epigenetic modification and growth of progeny

Jang

Kim

Purvis³

et al. 2020

Journal of Animal Science

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The study was conducted to determine the effects of mineral methionine hydroxy analogue chelate (MMHAC) partially replacing inorganic trace minerals in sow diets on epigenetic and transcriptional changes in muscle and jejunum of progeny. The MMHAC is zinc (Zn), manganese (Mn), and copper (Cu) chelated with methionine hydroxy analogue (Zn-, Mn-, and Cu-MHAC). On d 35 of gestation, 60 pregnant sows were allotted to 2 dietary treatments in a randomized completed block design using parity as a block: (1) ITM: inorganic trace minerals with zinc sulfate (ZnSO4), manganese oxide (MnO), and copper sulfate (CuSO4) and (2) CTM: 50% of ITM was replaced with MMHAC (MINTREXtrace minerals, Novus International Inc., St Charles, MO). Gestation and lactation diets were formulated to meet or exceed NRC requirements. On d 1 and 18 of lactation, milk samples from 16 sows per treatment were collected to measure immunoglobulins (IgG, IgA, and IgM) and micromineral concentrations. Two pigs per litter were selected to collect blood to measure the concentration of immunoglobulins in the serum, and then euthanized to collect jejunal mucosa, jejunum tissues, and longissimus muscle to measure global DNA methylation, histone acetylation, cytokines, and jejunal histomorphology at birth and d 18 of lactation. Data were analyzed using Proc MIXED of SAS. Supplementation of MMHAC tended to decrease (P = 0.059) body weight (BW) loss of sows during lactation and tended to increase (P = 0.098) piglet BW on d 18 of lactation. Supplementation of MMHAC increased (P < 0.05) global histone acetylation and tended to decrease myogenic regulatory factor 4 (MRF4) messenger ribonucleic acid (mRNA) (P = 0.068) and delta 4-desaturase sphingolipid1 (DEGS1) mRNA (P = 0.086) in longissimus muscle of piglets at birth. Supplementation of MMHAC decreased (P < 0.05) nuclear factor kappa B (NF-κB) mRNA in the jejunum and DEGS1 mRNA in longissimus muscle, and tended to decrease mucin-2 (MUC2) mRNA (P = 0.057) and transforming growth factor beta 1 (TGF-β1) mRNA (P = 0.057) in the jejunum of piglets on d 18 of lactation. There were, however, no changes in the amounts of TNF-α, IL-8, TGF-β, MUC2, and MYF6 in the tissues by MMHAC. In conclusion, maternal supplementation of MMHAC could contribute to histone acetylation and programming in the fetus, which potentially regulates intestinal health and skeletal muscle development of piglets at birth and weaning, possibly leading to enhanced growth of their piglets.

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Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets

Abstract: View related articlesView Crossmark data Citing articles: 1 View citing articles Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets

Cited by 12 publications

References 45 publications

The effect of feed supplementation with a copper-glycine chelate and copper sulphate on cellular and humoral immune parameters in chickens

The effect of feed supplementation with a copper-glycine chelate and copper sulphate on cellular and humoral immune parameters in chickens

Effects of High Dietary Copper Supplementation on the Copper Accumulation and Total Copper Content in Fattening Pigs

Effects of mineral methionine hydroxy analog chelate in sow diets on epigenetic modification and growth of progeny

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