Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis

Chen, Jing; Wang, Zhengyi; Fu, Xue Yan

doi:10.1186/s12885-020-07139-y

Cited by 19 publications

(14 citation statements)

References 44 publications

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“…Systematic reviews have indicated that patients with diabetes had an increased risk of GBC and a higher GBC-mediated mortality compared with non-diabetic individuals. 34,35 In addition to CEA and CA199, 36 we found that CA724 may be a potential biomarker for GBC. However, in this study, there were too many missing data points, and we are prospectively collecting relevant results to obtain stronger evidence for CA724 as a potential biomarker.…”

Section: Discussionmentioning

confidence: 79%

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

Zhang

Wang

Qin

et al. 2021

J Clin Transl Hepatol

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Background and Aims: Gallbladder polyp (GBP) assessment aims to identify the early stages of gallbladder carcinoma. Many studies have analyzed the risk factors for malignant GBPs. In this retrospective study, we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs. Methods: We developed a nomogram-based model in a training cohort of 233 GBP patients. Clinical information, ultrasonographic findings, and blood test findings were analyzed. Mann-Whitney U test and multivariate logistic regression analyses were used to identify independent predictors and establish the nomogram model. An internal validation was conducted in 225 consecutive patients. Performance and clinical benefit of the model were evaluated using receiver operating characteristic curves and decision curve analysis (DCA), respectively. Results: Age, cholelithiasis, carcinoembryonic antigen, polyp size, and sessile shape were confirmed as independent predictors of GBP neoplastic potential in the training group. Compared with five other proposed prediction methods, the established nomogram model presented better discrimination of neoplastic GBPs in the training cohort (area under the curve [AUC]: 0.846) and the validation cohort (AUC: 0.835). DCA demonstrated that the greatest clinical benefit was provided by the nomogram compared with the other five methods. Conclusions: Our developed preoperative nomogram model can successfully be used to evaluate the neoplastic potential of GBPs based on simple clinical variables that maybe useful for clinical decisionmaking.

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Section: Discussionmentioning

confidence: 79%

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

Zhang

Wang

Qin

et al. 2021

J Clin Transl Hepatol

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“…Gallbladder cancer (GBC) is the most common malignant tumor of the biliary tract. Although it is relatively rare, its median survival rate is only about 6 months (119). Deoxycholic acid (DCA) is down-regulated in GBC.…”

Section: Gallbladder Cancermentioning

confidence: 99%

The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

Lin

Man

et al. 2022

Front. Oncol.

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N6-methyladenosine (m6A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m6A modification process by affecting the expression of m6A-related enzymes. The interaction between m6A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m6A and non-coding RNAs in gastrointestinal tract cancers.

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“…Увеличение затрат на лечение данного дорогостоящего заболевания ложится экономическим бременем как на финансовые расходы государств, так и на самих пациентов. Все это подчеркивает необходимость дальнейшего определения стратегии скрининга факторов риска, а также разработки дополнительных мер по снижению распространенности и смертности от СД2 [1].…”

Section: обоснованиеunclassified

Assessment of the relationship between prediabetes and low skeletal mass based on blood creatinine level

et al. 2022

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BACKGROUND: Low muscle mass increases the risk of developing type 2 diabetes mellitus (DM 2) and prediabetes. Nutrition is an important factor in the study of the relationship between low muscle mass and the development of glucose metabolic disorders.AIM: The present study was conducted to assess the relationship between prediabetes and low muscle mass on the basis of serum creatinine levels, taking into account patient nutrition.MATERIALS AND METHODS: The study included 551 patients aged 18–69 years without DM 2. The glucose level was determined based on fasting glucose and after an oral glucose tolerance test (OGTT). Hyperglycemia is assessed according to the classification of the World Health Organization. The MedDietScore questionnaire was used to assess the nutritional factor, which determines the adherence of patients to the Mediterranean diet. In order to assess odds ratios (OR) and 95% confidence interval (CI), a binary logistic regression was performed.RESULTS: The prevalence of prediabetes in the group with the lowest and highest blood creatinine level was 31.9% and 17.5% respectively (p=0.016). As a result of the conducted regression analysis, a statistically significant relationship was found between low creatinine levels and the chances of having prediabetes (crude OR 2,07, 95% CI 1,21; 3,56), which persisted after adjusting for socio-demographic, anthropometric factors, stress level and physical activity as well as muscle strength. After adding the data on MedDietScore to the statistical model, the revealed relationship was lost (p = 0.187).CONCLUSION: Low serum creatinine increases the chances of the presence of prediabet regardless of gender, age, body weight index, the volume of the hips, the ratio of the volume of the waist to growth, as well as physical activity, the level of stress and muscular power. However, the chances of the presence of prediabet do not differ in persons with low creatinine blood depending on the commitment to the Mediterranean diet among the population of those living in the Turkestan region.

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Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis

Cited by 19 publications

References 44 publications

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

Assessment of the relationship between prediabetes and low skeletal mass based on blood creatinine level

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