Effect of components (polymer, plasticizer and solvent) as a variable in fabrication of diclofenac transdermal patch

Abstract

Transdermal drug delivery influence consumer acceptance and marked increase in bioavailability of some drugs which undergoes hepatic first-pass metabolism. Fabrication of transdermal patch requires lots of attention regarding the amount of components used for it. Because of varied nature of polymer and plasticizer, transdermal patches have different properties and different drug release. This study is on the basis to evaluate the amount to be needed for fabrication of diclofenac transdermal patch. Study shows that Hydroxy Propyl Methyl Cellulose has great influence on transdermal patch, if it is used alone in combination with glycerin or PEG-4000 plasticizer.

In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

“…Polimers variation would cause the different properties and release pattern ot the patch. 23 Drug release from the matrix system would be rapid at the start and decreased by the time until the matrix fully dissolved. Amount of drug in the matrix and the matrix properties would affect the rate of drug release in transdermal therapeutic system.…”

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“…However, release kinetics followed zero order. (Sethi and Mazumder 2018) Chetna Modi et al, (2012) 81 studied that transdermal patch fabrication necessitates close attention to the amount of materials used. It was discovered that transdermal patches have different properties and drug releases due to the varied type of polymers and plasticizers used.…”

“…Finally, the study aimed to determine the amount of diclofenac transdermal patch that would be needed. When used alone or in conjunction with glycerin or PEG-4000 plasticizer, Hydroxy Propyl Methyl Cellulose has a significant impact on transdermal patches, according to a report 81 . Studied that there were several considerations in optimizing a transdermal drug delivery system and the choice and design of polymers, adhesives, penetration enhancers, and plasticizers in transdermal systems are crucial for drug release characteristics as mechanical properties of the formulation.…”