Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial

Jovanovski, Elena; Duvnjak, Lea; Komishon, Allison; Au‐Yeung, Fei; Sievenpiper, John L.; Zurbau, Andreea; Jenkins, Alexandra L.; Sung, Mi‐Kyung; Josse, Robert G.; Li, Dandan; Vuksan, Vladimir

doi:10.1016/j.jgr.2019.11.005

Cited by 18 publications

(26 citation statements)

References 34 publications

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“…Besides, a randomized, placebo‐controlled, double-blind study in 20 type 2 diabetic patients (mean age: 51.5 ± 1.9 years) observed about 45% reduction in HOMA-IR in the group which was given P. ginseng supplementation compared to 12% reduction for the placebo group ( 146 ). Moreover, combinatory administration of Panax ginseng and Panax quinquefolius in a 12 week long randomized controlled trial on 80 type 2 diabetic subjects (49 were male and 31 were female) reduced another glycemic control parameter, namely HbA1c by −0.35 ± 0.1% along with blood lipid parameters (total cholesterol, LDL-C, triglycerides) and 24-hour systolic blood pressure without causing any side effects ( 147 ).…”

Section: Panax Ginseng C a Meyermentioning

confidence: 99%

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

et al. 2022

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Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic drugs because of the development of resistance and side effects of those drugs in long-term use. On the contrary, plants or herbal sources are getting popular day by day to the scientists, researchers, and pharmaceutical companies all over the world to search for potential bioactive compound(s) for the discovery and development of targeted novel antidiabetic drugs that may control diabetes with the least unwanted effects of conventional antidiabetic drugs. In this review, we have presented the prospective candidates comprised of either isolated phytochemical(s) and/or extract(s) containing bioactive phytoconstituents which have been reported in several in vitro, in vivo, and clinical studies possessing noteworthy antidiabetic potential. The mode of actions, attributed to antidiabetic activities of the reported phytochemicals and/or plant extracts have also been described to focus on the prospective phytochemicals and phytosources for further studies in the discovery and development of novel antidiabetic therapeutics.

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Section: Panax Ginseng C a Meyermentioning

confidence: 99%

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

et al. 2022

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Section: Introductionmentioning

confidence: 99%

“…Many clinical studies have investigated the potential protective effects of ginseng on cardiometabolic indices among individuals with diabetes; however, the results have been inconsistent [1,5,[21][22][23][24][25]. Some studies documented improved levels of anthropometric indices [1], glucose-related markers [26,27], lipid profile components [5], blood pressure [28], and inflammatory markers [21] following ginseng consumption, whereas others indicated null effects [12,22,29,30]. Furthermore, previous systematic reviews and meta-analyses of randomized controlled trials (RCTs) on ginseng supplementation have only covered certain cardiometabolic indicators in various health conditions [19,[31][32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Ginseng (Panax) on Human Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2022

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Results from different clinical trials on the effects of ginseng on prediabetes and type 2 diabetes (T2DM) are still inconsistent. To fill this knowledge gap, we investigated the overall effects of ginseng supplementation on improving cardiometabolic biomarkers among these patients. A systematic literature search was conducted on PubMed/MEDLINE, Scopus, Web of Science, and Cochrane library. A random-effect model was applied to estimate the weighted mean difference and 95% CI for each outcome. Overall, 20 eligible RCTs were included. Meta-analyses revealed that ginseng supplementation significantly reduced serum concentration of FPG, TC, IL-6, and HOMA-IR values. It also increased HR and TNF-α levels. Ginseng supplementation changed HOMA-IR and HDL-C significantly based on dose and changed HOMA-IR and LDL-C significantly based on study duration in a non-linear fashion. Furthermore, meta-regression analyses indicated a linear relationship between ginseng dose and absolute changes in HDL-C. Moreover, subgroup analyses showed that ginseng supplementation changed TC and LDL-C when the supplementation dose was ≥2 g/day. Our findings suggest that ginseng supplementation may be an effective strategy for improving cardiometabolic profiles in individuals with prediabetes and T2DM.

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“…It has been utilized in functional foods, herbal medicine, and so on. American ginseng possesses various medicinal properties, such as antihyperglycemic [ 5 , 6 ], immunologic [ 7 , 8 ], cardiovascular [ 9 , 10 ], antioxidant [ 11 , 12 ], and anticancer effects [ 13 ], as well as improved neurocognitive function. Most of these medicinal effects are attributed to its main constituents, polysaccharides and ginsenosides [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Green and Efficient Extraction of Polysaccharide and Ginsenoside from American Ginseng (Panax quinquefolius L.) by Deep Eutectic Solvent Extraction and Aqueous Two-Phase System

Zhou

Huang

et al. 2022

Molecules

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In this study, a green and effective extraction method was proposed to extract two main compounds, ginsenosides and polysaccharides, from American ginseng by combining deep eutectic solvents (DESs) with aqueous two-phase systems. The factors of type of DESs, water content in DESs, the solid–liquid ratio, extraction temperature, and extraction time were studied in the solid–liquid extraction. Then, the aqueous two-phase system (DESs-ethylene oxide–propylene oxide (EOPO)) and salty solution exchange (EOPO-salty solution) was applied for the purification of polysaccharides. The content of the polysaccharides and ginsenosides were analyzed by the anthrone–sulfuric acid method and HPLC method, which showed that the extraction efficiency of deep eutectic solvents (DESs) was better than conventional methods. Moreover, the antioxidant activities of ginseng polysaccharides and their cytotoxicity were further assayed. The advantages of the current study are that, throughout the whole extraction process, we avoided the usage of an organic reagent. Furthermore, the separated green solvent DESs and EOPO could be recovered and reused for a next cycle. Thus, this study proposed a new, green and recyclable extraction method for extracting ginsenosides and polysaccharides from American ginseng.

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Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial

Cited by 18 publications

References 34 publications

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

The Efficacy of Ginseng (Panax) on Human Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Green and Efficient Extraction of Polysaccharide and Ginsenoside from American Ginseng (Panax quinquefolius L.) by Deep Eutectic Solvent Extraction and Aqueous Two-Phase System

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