Effect of Chlorhexidine on the Hamster Cheek Pouch: Microcirculation and Penetration Studies

Luostarinen, V.; Söderling, Eva; Knuuttila, Matti; Paunio, Keijo

doi:10.1902/jop.1977.48.7.421

Cited by 13 publications

(4 citation statements)

References 5 publications

(5 reference statements)

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“…Although a few studies have demonstrated that CHX does not affect collagen synthesis during wound healing (18) with beneficial effects (19), others state that this drug has a clear delaying effect on granulation tissue formation (20), inducing microcirculatory changes (21), and retarding wound healing (22). Cytotoxic effects of CHX might explain this delayed healing.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Chlorhexidine Toxicity Injected in the Paw of Mice and Added to Cultured L929 Fibroblasts

Faria

Celes

Rossi

et al. 2007

Journal of Endodontics

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Section: Discussionmentioning

confidence: 99%

Evaluation of Chlorhexidine Toxicity Injected in the Paw of Mice and Added to Cultured L929 Fibroblasts

Faria

Celes

Rossi

et al. 2007

Journal of Endodontics

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“…To the authors' knowledge, Sr has not caused mucosal irritation, whereas chlorhexidine has been shown to adsorb on the surface of oral tissues (R6lla et al, 1971), but this is largely reversible. The absorption of chlorhexidine by oral mucosa appears either nil (Davies and Hull, 1973) or very small (Luostarinen et al, 1977).…”

Section: Discussionmentioning

confidence: 99%

Effect of Chlorhexidine-Fluoride Applications Without and With Sr and Zn on Caries, Plaque, and Gingiva in Rats

et al. 1984

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Molar teeth of four groups of Osborne-Mendel rats, kept on a cariogenic diet, were treated once per day for 48 days with either distilled water (solution C), a solution containing 0.05% chlorhexidine gluconate and 0.04% NaF, pH 5.8 (solution CXF), CXF plus 1000 ppm Sr (solution CXFS), or CXFS plus 1000 ppm Zn (solution CXFSZ). Caries of the hemi-sectioned lower molars was scored according to grades of severity, and the extent of the buccal plaque was estimated. Inflammatory cell infiltration, vascularity, and thickness of the oral mucosa were estimated from stained sections of the buccal oral mucosa to detect possible adverse effects of the treatments. Fissure caries lesions with involvement of the dentin were reduced by 57% (p less than 0.01) with the CXF treatment and by 68% (p less than 0.001) with the CXFS treatment. The CXFSZ treatment reduced the fissure caries least (44%, p less than 0.05), but it appreciably reduced the extent of plaque. The mucosal changes were greatest in the group receiving the CXFSZ treatment, but they were generally small and at a non-pathological level. Supplementation of the CXF solution with Sr thus appeared beneficial for caries reduction.

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“…The effect differs from the effect of chlorhexidine, which increased the velocity of the hamster cheek pouch for 13 min by 50% in a similar type of experiment reported by LDOSTARINEN etal. (15).…”

Section: Discussionmentioning

confidence: 99%

Vascular and cellular responses to guanidino propyl piperazine CK0569A, a new anti‐plaque agent

Hurttia

Knuuttila

Söderling

et al. 1987

European J Oral Sciences

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Hurttia H, Knuuttila M, Soderling E, Luostarinen V, Paunio K: V^ascular and cellular responses to guanidino propyl piperazine CK0569A, a new anti-plaque agent. Scand J Dent Res 1987; 95: 104-11.Abstract -Guanidino propyl piperazine GK0569A (abbreviation piperazine) used as a 0.1% mouthrinse bas been shown to be effective against plaque bacteria. In addition to its efficacy as an antibacterial agent, its safety sbould be taken into consideration. In this study the eifect of piperazine on the microcirctilation of the hamster cheek pouch was studied. The effect of this drug was also investigated on rat leukocytes in vivo and on macrophages and erythrocytes in vitro. Piperazine caused a distinct retardation in the microcirculation of tbe hamster cheeck pouch even at a low concentration (0.01%), but the effect was abolished in 5 min. The number of leukocytes decreased nsarkedly in the experimentally induced inflammatory exudate in the presence of 0.05% piperazine as compared to the controls. Tbe macrophages in vitro released their iysosomal and cytoplasmic enzymes and lost tbeir viability. The erythrocytes in vitro were destroyed in the presence of 0.005% piperazine as well. Based on these results it can be suggested that 0.005-0.05% piperazine under experimental conditions causes changes that indicate loss of cell viability.

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Effect of Chlorhexidine on the Hamster Cheek Pouch: Microcirculation and Penetration Studies

Cited by 13 publications

References 5 publications

Evaluation of Chlorhexidine Toxicity Injected in the Paw of Mice and Added to Cultured L929 Fibroblasts

Evaluation of Chlorhexidine Toxicity Injected in the Paw of Mice and Added to Cultured L929 Fibroblasts

Effect of Chlorhexidine-Fluoride Applications Without and With Sr and Zn on Caries, Plaque, and Gingiva in Rats

Vascular and cellular responses to guanidino propyl piperazine CK0569A, a new anti‐plaque agent

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