The aim was to study whether topically applied local anaesthetics and related compounds exert an antithrombotic effect. The assay was carried out through vital microscopy of the microcirculation in the hamster cheek pouch model as injured by laser microbeam irradiation, essentially in order to record the differences in the incidence of thrombus formation between two main experimental and control series. The application of lidocaine hydrochloride was found to inhibit thrombus formation and also to restore the microcirculation after laser-induced injury. The other investigated compounds, mono-ethyl-glycinexylidide, tocainide and bupivacaine were found to be less active with regard to inhibition of thrombus formation and flow restitution effects. It is concluded that an antithrombotic effect may be attributed to lidocaine in particular.
Pulp tissue, enamel and incisal and basal dentine of the mandibular incisor were taken from one litter of rats and transplanted subcutaneously or intracerebrally to sex-matched, 5-day-old animals of the subsequent litter of the same parents. As sham-operations the mere transplantation instrument was inserted into the transplantation sites. With some exceptions, the host animals were killed 4, 32, 128–138 and 210 days after the operation and the transplantation sites were examined either grossly or microscopically or both. The pulp tissue transplantation had resulted in formation of osseous tissue observed 128 days post-operatively. Bone was found in association with many of the basal dentine transplants 128–210 days after their insertion whereas no such tissue was observed with the transplanted enamel of incisal dentine. The sham-operation seemed to have elicited intracerebral bone formation in two animals. The osteoinductive activity of the transplanted tissues seemed reduced by their mineral phase. Further, in contrast to deminerahzed hard tissues, the non-demineralized inductive agents do not seem to possess bone morphogenetic properties.
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