Antithrombotic Effects of Lidocaine and Related Compounds on Laser‐Induced Microvascular Injury

Abstract

The aim was to study whether topically applied local anaesthetics and related compounds exert an antithrombotic effect. The assay was carried out through vital microscopy of the microcirculation in the hamster cheek pouch model as injured by laser microbeam irradiation, essentially in order to record the differences in the incidence of thrombus formation between two main experimental and control series. The application of lidocaine hydrochloride was found to inhibit thrombus formation and also to restore the microcirculation after laser-induced injury. The other investigated compounds, mono-ethyl-glycinexylidide, tocainide and bupivacaine were found to be less active with regard to inhibition of thrombus formation and flow restitution effects. It is concluded that an antithrombotic effect may be attributed to lidocaine in particular.

Comparação dos efeitos da infiltração com bupivacaína, lidocaína e tramadol na cicatrização de feridas em ratos

“…While our study found results similar to previous studies on the effects of bupivacaine and lidocaine on wound healing [30][31][32][33][34][35][36][37][38][39][40][41] , no significant difference was found between tramadol and the control group. The antibacterial properties of local anesthetics and other agents used in wound infiltration are important.…”

“…Research on lidocaine in wound infiltration of rats found collagenization and effects on mast cell numbers in the wound 36 . Aside from local anesthesia affecting collagen fiber numbers and capillary veins, it may cause varying degrees of inflammation and edema along the wound edges which can affect wound healing 3,37,38 .…”

Coagulation and fibrinolytic parameters in patients undergoing total hip replacement: influence of the anaesthesia technique

“…Our group has also found a lower incidence of DVT after epidural block in a study comparing the above-mentioned techniques in this kind of surgery: 45% after general anaesthesia, 25% after epidural anaesthesia, and 38% after the association of both (37). Whether this is due mostly to rheologic changes (8), to the protection of the endothelial cells (38) and/ or to a decrease of platelet aggregation (39) caused by the local anaesthetic, or to the withholding of positive pressure ventilation (40), remains speculative. A faster return to normal of the AT I11 and higher level of PG…”

The Comparison of the Effects of Different Doses of Levobupivacaine Infiltration on Wound Healing

“…Analysis of fibrotic indexes in groups the negative effects of bupivacaine and lidocaine on wound healing, showing the mechanism underlying these effects to be the inhibition of lysophosphatidate, which is responsible for the proliferation of fibroblasts and smooth muscles [11]. Besides the studies expressing the number of collagen fibers and capillary vessels affected, there are studies that show, the edema and the different levels of inflammation on the wound lips prolong the wound healing [12,13]. There are studies that show local anesthetics used in high concentrations prolong the wound healing [7,14,15].…”