Effect of Cadmium Exposure on Increasing Risk of Diabetes Melitus Through the Measurement of Blood Glucose Level and Liver Glucokinase Activity in Rats

Thalib, Iskandar; Budianto, Windy Yuliana; Suhartono, Eko

doi:10.20527/jbk.v13i2.4068

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…In addition, some metals like cadmium can alter the structure of macromolecules [ 50 ]. Cadmium brings conformational changes with corresponding increased K m value to the structure of glucokinase in the liver; this means that cadmium reduces the affinity between glucose and glucokinase [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Cadmium exposure induces cardiac glucometabolic dysregulation and lipid accumulation independent of pyruvate dehydrogenase activity

et al. 2021

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Context: Suppressed glucose metabolism, elevated fatty acid metabolism and lipid deposition within myocardial cells are the key pathological features of diabetic cardiomyopathy. Studies have associated cadmium exposure with metabolic disturbances. Objective: To examine the effects of cadmium exposure on cardiac glucose homeostasis and lipid accumulation in male Wistar rats. Methods: Male Wistar rats were treated for 21 days as (n ¼ 5): Control, cadmium chloride Cd5 (5 mg/kg, p.o.), cadmium chloride Cd30 (30 mg/kg, p.o). Results:The fasting serum insulin level in this study decreased significantly. Pyruvate and hexokinase activity reduced significantly in the Cd5 group while no significant change in lactate and glycogen levels. The activity of pyruvate dehydrogenase enzyme significantly increased with an increasing dosage of cadmium. The free fatty acid, total cholesterol and triglyceride levels in the heart increased significantly with increasing dosage of cadmium when compared with the control. Lipoprotein lipase activity in the heart showed no difference in the Cd5 group but a reduction in the activity in the Cd30 group was observed. Conclusion:This study indicates that cadmium exposure interferes with cardiac substrate handling resulting in impaired glucometabolic regulation and lipid accumulation which could reduce cardiac efficiency.

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Section: Discussionmentioning

confidence: 99%

Cadmium exposure induces cardiac glucometabolic dysregulation and lipid accumulation independent of pyruvate dehydrogenase activity

et al. 2021

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Interaction of cadmium-cysteine binding and oxidation of protein causes of blood thrombosis

Marisa

Aflanie

Muthmainah

et al. 2019

J. Phys.: Conf. Ser.

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Thrombosis occurs if the balance between thrombogenic factors and protective mechanisms is disrupted. These disorders can be caused by endothelial disorders due to the presence of heavy metals such as cadmium (Cd). These amino acid residues can bind Cd metal covalently with the -S-S-, -C-S-, -SH, and phenyl groups, which are present in the amino acid residues. This situation causes changes in the structure of the protein, so that it becomes modified and forms a blood clot (thrombosis). However, the spectroscopic interaction of cadmium-cysteine as causes of thrombosis has not been widely studied. Therefore, this research needs to be done. The research conducted was an experimental study with posttest control with group design. This study used healthy blood obtained from PMI Banjar regency. This study used one control group and three treatment groups, namely P0 = control group, blood without Cd; P1 = blood group with Cd 0.003 mg/l; P2 = blood group with Cd 0.03 mg/l; P3 = blood group with Cd 0.3 mg/l; P4 = blood group with Cd 3 mg/l. Furthermore, each group was incubated for 45 minutes at 37°c. Then cloth weight, AOPP levels, and absorbance were measured at wavelengths 253 nm. The results showed that an increase in cadmium levels caused an increase in the rate of thrombosis. This increase is associated with an increase in AOPP levels. Cadmium can bind covalently with cysteine and other amino acids which results in the breakdown of peptide bonds. The study concluded that cd accelerated the rate of thrombosis due to increased protein oxidation (aopp). This oxidation is caused by binding cd to cysteine with kbind = 0.355.

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Pilot Study of Trace Elements in the Infusion of Medicinal Plants Used for Diabetes Treatment

Brima

Siddeeg

2022

International Journal of Analytical Chemistry

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The purpose of this study was to evaluate trace element contents in different medicinal plants used for diabetes treatments by residents in Asir region. Five medicinal plants—Tut leaves (Mulberry), olive leaves (Olea europaea), clove (Syzygium aromaticum), Luban Dhakar (Boswellia carterii), and Karela or bitter melon (Momordica charantia)—were collected from two cities, Khamis Mushait and Abha, in the Asir region, Saudi Arabia. Infusions (hot water extracts) were obtained from each plant, and elemental analysis was conducted using inductively coupled plasma mass spectrometry (ICP-MS). Fourteen elements (Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Sr, Cd, Ba, and Pb) were measured in all plants. The results revealed that the fourteen elements were present at different levels (µg/g) in all plants. Momordica charantia exhibited high levels of essential (Mn (251.4), Co (1.18), Cu (54.64), and Se (2.18)) and toxic elements (Al (39.20), As (0.57), Cd (0.33), and Pb (4.48)), followed by Syzygium aromaticum (Mn (736.36)) and Boswellia carterii (Pb (0.93)), which exceeded the PMTDI in traditional doses used for diabetes treatments. However, Mulberry and Olea europaea did not exceed the daily guideline values for all elements. Based on our findings, we cautiously recommend the latter two plants for the traditional treatment of diabetes, because they are not considered as source of harm based on their levels of elements. Their use should be restricted by comprehensive compound analysis to guarantee their safe use.

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Effect of Cadmium Exposure on Increasing Risk of Diabetes Melitus Through the Measurement of Blood Glucose Level and Liver Glucokinase Activity in Rats

Cited by 3 publications

References 18 publications

Cadmium exposure induces cardiac glucometabolic dysregulation and lipid accumulation independent of pyruvate dehydrogenase activity

Cadmium exposure induces cardiac glucometabolic dysregulation and lipid accumulation independent of pyruvate dehydrogenase activity

Interaction of cadmium-cysteine binding and oxidation of protein causes of blood thrombosis

Pilot Study of Trace Elements in the Infusion of Medicinal Plants Used for Diabetes Treatment

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