Effect of Asiaticoside Rich Extract from Centella asiatica (L.) Urb. on Physical Fatigue Induced by Weight-loaded Forced Swim Test

Anand, T.; Kumar, G. Phani; Nallamuthu, Ilaiyaraja; Khanum, Farhath; Bawa, A. S.

doi:10.3923/ajava.2012.832.841

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Particularly, the 70 kDa Hsp-70 contributes to stress tolerance by increasing its chaperone activity. The role of this protein has also been implicated in physical stress like swimming (Anand et al, 2012b), and therefore we have measured its expression in liver tissues. Our results indicated that AME extract down-regulates HSP expression that was over-expressed by swimming stress through various physiological responses.…”

Section: Discussionmentioning

confidence: 99%

Effect of hydroalcoholic extract ofAegle marmelosfruit on radical scavenging activity and exercise-endurance capacity in mice

Nallamuthu

Anand

Khanum

2014

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Effect of hydroalcoholic extract ofAegle marmelosfruit on radical scavenging activity and exercise-endurance capacity in mice

Nallamuthu

Anand

Khanum

2014

Pharmaceutical Biology

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“…Antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidise, and glutathione reductase (CAT, SOD, GPx, and GR, respectively) were determined as per user manual of commercially available kits (Bio-Vision, USA). The assay for lipid peroxidation was determined as mentioned by Anand et al (2012).…”

Section: Estimation Of Antioxidant Enzymes and Lipid Peroxidationmentioning

confidence: 99%

Adaptogenic potential of ginsenosides against domoic acid‐induced toxicity by regulating neuronal stress and kinate receptors: Ex vivo and in silico studies

Ramya

Kumar

Yadavalli

2022

Journal of Food Biochemistry

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This study is focused on potential effects of ginsenosides from Panax ginseng (PG) against amnesic shell fish poison, that is, domoic acid-induced excitotoxicity. Mice received PG at two different dosages by oral feeding for a period of 28 days (50 and 100 mg kg −1 bwt. −1 ). Domoic acid was injected to the mice to induce excitotoxicity (DA; 3 mg kg −1 bwt. −1 ) and piracetam-injected animals (PIR; 100 mg kg −1 bwt. −1 ) were treated as positive control. DA-induced cognitive impairment was reverted by PG supplementation, which was observed in Morris water maze and novel object task. Moreover, PG supplementation restored levels of GABA and antioxidant enzymes. Our results further elucidated ameliorative effects of PG supplementation on DA-induced changes in the expression of synaptic plasticity (BDNF), inflammation (NFkB), and apoptotic (Bcl2, Bax, and Caspase 3) markers. Hence, this study elucidates potential nootropic effects of ginsenosides from P. ginseng extract against DA-induced neuronal impairments via, modulation of behavioral and biochemical mechanisms involved in excitotoxicity, oxidative stress, neuro-inflammation, and apoptosis. Practical applicationsThis study highlights potential effects of ginsenosides from Panax ginseng against amnesic shell fish poison, that is, domoic acid-induced excitotoxicity for the first time. This study confirms that ginsenosides have the beneficial effects against amelioration of DA-induced toxicity. This study elucidates the potential nootropic effects of P. ginseng extract against DA-induced neuronal impairments via, modulation of synaptic plasticity markers and oxido-inflammatory responses leading to apoptosis. This study will be helpful in offering various mechanisms involved in pharmacological applications of P. ginseng in the management of DA-induced excitotoxicity.

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“…Centella asiatica L. Urban belongs to family Apiaceae or Umbelliferae, and used as a psychoactive therapeutic plant being utilized from ancient time in Ayurvedic framework of pharmaceutical as a medhya rasayna (68). It has been appeared to reduce the oxidative stress symptoms.…”

Section: Centella Asiaticamentioning

confidence: 99%

Herbal Medicine as Neuroprotective Potential Agent in Human and Animal Models: A Historical Overview

Abdolmaleki¹,

Akram²,

Saeed³

et al. 2020

jpc

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Neurodegenerative disorders could be a most important health issue within the 21st century. In the recent past; there has been a growing interest in medicinal plants. Chemical fruits and vegetables are said to decrease the possibility of many chief ailments, together with cardiovascular and cancer disorders as well as neurodegenerative ailments. Hence, who eat more fruits and vegetables may be less threaten for developing certain diseases caused by neurological dysfunction. The present review provides an overview of the about 14 most important plants used for neurological disorders and explores their neurological protection for the development of new pharmacological potential drugs. The data sources including the publications on Google Scholar, PubMed, and Science Direct. Publications searched with no particular time restriction in order to get a holistic and comprehensive view of the research done on this topic so far. Therefore, we present a systematic approach for herbal medicine as neuroprotective agent. From ancient time the herbal medicines are used to cure neurological symptoms. While the exact pharmacology of these herbs has not yet been set on, some of them have anti-inflammatory or antioxidant properties on different peripheral systems. The significant variety of medicinal plants makes it an essential source of healthy compounds compared to current therapeutic agents. In this review, the importance of phytochemicals for the function of neurological protection and other related disorders, in particular, the process mechanism and therapeutic prospective will be emphasize.

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Effect of Asiaticoside Rich Extract from Centella asiatica (L.) Urb. on Physical Fatigue Induced by Weight-loaded Forced Swim Test

Cited by 6 publications

References 15 publications

Effect of hydroalcoholic extract ofAegle marmelosfruit on radical scavenging activity and exercise-endurance capacity in mice

Effect of hydroalcoholic extract ofAegle marmelosfruit on radical scavenging activity and exercise-endurance capacity in mice

Adaptogenic potential of ginsenosides against domoic acid‐induced toxicity by regulating neuronal stress and kinate receptors: Ex vivo and in silico studies

Herbal Medicine as Neuroprotective Potential Agent in Human and Animal Models: A Historical Overview

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