Adaptogenic potential of ginsenosides against domoic acid‐induced toxicity by regulating neuronal stress and kinate receptors: Ex vivo and
in silico
studies
Abstract:This study is focused on potential effects of ginsenosides from Panax ginseng (PG) against amnesic shell fish poison, that is, domoic acid-induced excitotoxicity. Mice received PG at two different dosages by oral feeding for a period of 28 days (50 and 100 mg kg −1 bwt. −1 ). Domoic acid was injected to the mice to induce excitotoxicity (DA; 3 mg kg −1 bwt. −1 ) and piracetam-injected animals (PIR; 100 mg kg −1 bwt. −1 ) were treated as positive control. DA-induced cognitive impairment was reverted by PG suppl… Show more
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